{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T15:09:07Z","timestamp":1777648147488,"version":"3.51.4"},"reference-count":19,"publisher":"Walter de Gruyter GmbH","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2023-0150_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Congenital hypothyroidism (CH) is a decrease in thyroid hormone function in newborns, being one of the\u00a0leading causes of neurological deficits and long-term metabolic complications. This study aims to determine the prevalence and characteristics of CH cases in Bogot\u00e1, Colombia, between 2015 and 2021, as notified through the mandatory report to the Public Health Surveillance System (PHSS).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2023-0150_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A retrospective cross-sectional study was conducted. All live births (LB) with a weight\u00a0\u2265500\u202fg, diagnosed with CH with or without goiter (ICD-10 codes E030 and E031, respectively) in Bogot\u00e1 during 2015\u20132021 were analyzed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2023-0150_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>For a total of 201 cases, the prevalence rate was 3.29\u00a0cases per 10,000 LB. 92.54\u202f% were classified as isolated cases of CH, 4.48\u202f% syndromic, and 2.98\u202f% polymalformated. A total of 16.92\u202f% was small for gestational age. The mean gestational age was 37.38\u00a0weeks (SD 2.76), 26.87\u202f% were preterm births. Among the mothers, 8.96\u202f% suffered from pregnancy-related or chronic diseases, the most common being hypertensive disorders of pregnancy and pre-existant hypothyroidism (without clarity concerning etiology). A\u00a0total\u00a0of 66.67\u202f% of cases did not receive treatment after diagnosis. Treatment was established by an average age of\u00a027\u00a0days after birth (SD 36.02) and 17\u00a0days after case notification to the PHSS (SD 36.13).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2023-0150_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Observed prevalence is similar to the rate reported by health authorities in Colombia but inferior to reports from high-income countries, highlighting the importance of improvements in the Colombian LB\u2019s screening program. Time to diagnosis and treatment was observed to be prolonged, suggesting that new pathways are required for timely CH treatment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2023-0150","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T05:43:00Z","timestamp":1689831780000},"page":"772-776","source":"Crossref","is-referenced-by-count":2,"title":["Congenital hypothyroidism in Bogot\u00e1, Colombia: a\u00a0current description (2015\u20132021)"],"prefix":"10.1515","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1861-767X","authenticated-orcid":false,"given":"Pablo","family":"Pineda-Sanabria","sequence":"first","affiliation":[{"name":"Faculty of Medicine , Pontificia Universidad Javeriana , Bogot\u00e1 , Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8451-5041","authenticated-orcid":false,"given":"Esteban","family":"Portilla-Rojas","sequence":"additional","affiliation":[{"name":"Faculty of Medicine , Pontificia Universidad Javeriana , Bogot\u00e1 , Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9699-5548","authenticated-orcid":false,"given":"Mar\u00eda Camila","family":"Le\u00f3n-Sanabria","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, Faculty of Medicine, Pontificia Universidad Javeriana , Bogot\u00e1 , Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4237-1259","authenticated-orcid":false,"given":"Daniela-Sof\u00eda","family":"Beltr\u00e1n-Barriga","sequence":"additional","affiliation":[{"name":"Faculty of Medicine , Pontificia Universidad Javeriana , Bogot\u00e1 , Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3904-7538","authenticated-orcid":false,"given":"Alexander","family":"Salazar-Reviakina","sequence":"additional","affiliation":[{"name":"Faculty of Medicine , Pontificia Universidad Javeriana , Bogot\u00e1 , Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9130-4231","authenticated-orcid":false,"given":"Ana Mar\u00eda","family":"Urue\u00f1a Serrano","sequence":"additional","affiliation":[{"name":"Birth Defects Surveillance of the Secretary of Health , Bogot\u00e1 , Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1642-8402","authenticated-orcid":false,"given":"Karen","family":"Sarmiento","sequence":"additional","affiliation":[{"name":"Department of Physiologic Sciences, Faculty of Medicine , Pontificia Universidad Javeriana , Bogot\u00e1 , Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0729-6866","authenticated-orcid":false,"given":"Ignacio","family":"Zarante","sequence":"additional","affiliation":[{"name":"Hospital Universitario San Ignacio , Bogot\u00e1 , Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2023,7,21]]},"reference":[{"key":"2023080909320503432_j_jpem-2023-0150_ref_001","doi-asserted-by":"crossref","unstructured":"Hinton, CF, Harris, KB, Borgfeld, L, Drummond-Borg, M, Eaton, R, Lorey, F, et al.. 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