{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:49:26Z","timestamp":1784036966360,"version":"3.55.0"},"reference-count":27,"publisher":"Walter de Gruyter GmbH","issue":"2","funder":[{"DOI":"10.13039\/501100009530","name":"Jawaharlal Institute Of Postgraduate Medical Education and Research","doi-asserted-by":"publisher","award":["JIP\/Res\/Intramural\/phs 1\/ 2021-22"],"award-info":[{"award-number":["JIP\/Res\/Intramural\/phs 1\/ 2021-22"]}],"id":[{"id":"10.13039\/501100009530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2023-0165_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To assess the effect of daily zinc supplementation for 12\u00a0weeks on thyroid auto-antibodies\u00a0\u2013 thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb), and oxidative stress in children with autoimmune thyroid disease (AITD) compared to standard therapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2023-0165_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This open-labeled, parallel, randomized controlled trial was done in a tertiary care teaching institute in south India. Children aged 3\u201318 years with AITD were randomized to receive 25\u202fmg elemental zinc daily for 12\u00a0weeks or standard therapy alone. The change in thyroid function tests (thyroid stimulating hormone, free T3, free T4), thyroid auto-antibody (TPOAb, TgAb) titers, oxidative stress markers (glutathione peroxidase, malondialdehyde, superoxide dismutase, and total antioxidant capacity) were compared.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2023-0165_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Forty children, 20 in each arm, were recruited in the study. We observed a female-to-male ratio of 7:1. Median duration of disease was 2 (0.25, 4.25) years. A total of 37 (92.5\u202f%) children were hypothyroid, two hyperthyroid, and one euthyroid at enrolment. A total of 13 children (32.5\u202f%) had associated co-morbidities, most commonly type 1 diabetes mellitus and systemic lupus erythematosus, three\u00a0(7.5\u202f%) each. We did not find any significant change in\u00a0thyroid function tests, thyroid auto-antibody titers, and\u00a0oxidative stress markers. However, the requirement of levothyroxine dose was significantly increased in the control arm, compared to the zinc group (p=0.03). Only four (20\u202f%) children had minor adverse effects like nausea, metallic taste, and body ache.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2023-0165_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Zinc supplementation did not have any effect\u00a0on thyroid auto-antibodies and oxidative stress. Zinc-supplemented children did not require escalation in levothyroxine dose.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2023-0165","type":"journal-article","created":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T19:41:15Z","timestamp":1703792475000},"page":"137-143","source":"Crossref","is-referenced-by-count":6,"title":["Effect of daily zinc supplementation for 12\u00a0weeks on serum thyroid auto-antibody levels in children and adolescents with autoimmune thyroiditis\u00a0\u2013 a randomized controlled trial"],"prefix":"10.1515","volume":"37","author":[{"given":"Ramachandran (Ramge)","family":"Sivakumar","sequence":"first","affiliation":[{"name":"Department of Pediatrics , Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) , Puducherry , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3781-8423","authenticated-orcid":false,"given":"Delhikumar","family":"Chinnaiah Govindareddy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) , Puducherry , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayaprakash","family":"Sahoo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology , Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) , Puducherry , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachariah","family":"Bobby","sequence":"additional","affiliation":[{"name":"Department of Biochemistry , Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) , Puducherry , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8320-1016","authenticated-orcid":false,"given":"Palanivel","family":"Chinnakali","sequence":"additional","affiliation":[{"name":"Department of Preventive and Social Medicine , Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) , Puducherry , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2024,1,1]]},"reference":[{"key":"2024021417134790869_j_jpem-2023-0165_ref_001","unstructured":"Liontiris, MI, Mazokopakis, EE. 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