{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T11:39:31Z","timestamp":1774611571160,"version":"3.50.1"},"reference-count":36,"publisher":"Walter de Gruyter GmbH","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We aimed to explore the associations of neonatal hypocalcemia with neonatal vitamin D deficiency and maternal vitamin D deficiency. A comprehensive systematic literature search using PubMed and web of science was performed for relevant articles from inception to February 17th, 2023. We used odds ratio (OR) and 95\u202f% confidence interval (CI) as effect sizes for our meta-analysis. Publication bias was evaluated using funnel plot, Begg\u2019s test, and Egger regression test. All the statistical analyses were performed using Stata 14.0. A total of 11 studies were included and analyzed, including 452 newborns with hypocalcemia and 2,599 newborns with normal serum calcium level. Our research results revealed that vitamin D deficiency in newborns may be related to the higher prevalence of hypocalcemia (OR: 2.87, 95\u202f% CI: 1.17\u20137.04). In addition, maternal vitamin D deficiency might also be a risk factor for neonatal hypocalcemia (OR: 7.83, 95\u202f% CI: 3.62\u201316.92). There was a significant correlation between vitamin D deficiency and neonatal hypocalcemia.This meta-analysis indicates that newborns with vitamin D deficiency have a higher risk of hypocalcemia, and maternal vitamin D level play a crucial role in this association. Vitamin D supplementation may have a positive effect in reducing the prevalence of neonatal hypocalcemia.<\/jats:p>","DOI":"10.1515\/jpem-2023-0183","type":"journal-article","created":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T10:50:33Z","timestamp":1693047033000},"page":"909-916","source":"Crossref","is-referenced-by-count":5,"title":["Relationship between vitamin D deficiency and neonatal hypocalcemia: a meta-analysis"],"prefix":"10.1515","volume":"36","author":[{"given":"Ruihan","family":"Li","sequence":"first","affiliation":[{"name":"School of Public Health , Wuhan University , Wuhan , P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aojing","family":"Han","sequence":"additional","affiliation":[{"name":"School of Public Health , Wuhan University , Wuhan , P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qilin","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Public Health , Wuhan University , Wuhan , P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Liang","sequence":"additional","affiliation":[{"name":"School of Public Health , Wuhan University , Wuhan , P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2023,8,28]]},"reference":[{"key":"2023100615123182669_j_jpem-2023-0183_ref_001","doi-asserted-by":"crossref","unstructured":"Elsary, AY, Elgameel, AA, Mohammed, WS, Zaki, OM, Taha, SA. Neonatal hypocalcemia and its relation to vitamin D and calcium supplementation. Saudi Med J 2018;39:247\u201353. https:\/\/doi.org\/10.15537\/smj.2018.3.21679.","DOI":"10.15537\/smj.2018.3.21679"},{"key":"2023100615123182669_j_jpem-2023-0183_ref_002","doi-asserted-by":"crossref","unstructured":"Smilie, C, Shah, D, Batra, P, Ahmed, RS, Gupta, P. Prevalence and predictors of hypocalcaemia in severe acute malnutrition. Public Health Nutr 2020;23:3181\u20136. https:\/\/doi.org\/10.1017\/s1368980020001895.","DOI":"10.1017\/S1368980020001895"},{"key":"2023100615123182669_j_jpem-2023-0183_ref_003","doi-asserted-by":"crossref","unstructured":"Mehrotra, P, Marwaha, RK, Aneja, S, Seth, A, Singla, BM, Ashraf, G, et al.. Hypovitaminosis d and hypocalcemic seizures in infancy. Indian Pediatr 2010;47:581\u20136. https:\/\/doi.org\/10.1007\/s13312-010-0131-1.","DOI":"10.1007\/s13312-010-0131-1"},{"key":"2023100615123182669_j_jpem-2023-0183_ref_004","doi-asserted-by":"crossref","unstructured":"H\u00e4stbacka, J, Pettil\u00e4, V. Prevalence and predictive value of ionized hypocalcemia among critically ill patients. Acta Anaesthesiol Scand 2003;47:1264\u20139. https:\/\/doi.org\/10.1046\/j.1399-6576.2003.00236.x.","DOI":"10.1046\/j.1399-6576.2003.00236.x"},{"key":"2023100615123182669_j_jpem-2023-0183_ref_005","doi-asserted-by":"crossref","unstructured":"Ayuk, J, Matthews, T, Tayebjee, M, Gittoes, NJ. A blind panic. Lancet 2001;357:1262. https:\/\/doi.org\/10.1016\/s0140-6736(00)04408-1.","DOI":"10.1016\/S0140-6736(00)04408-1"},{"key":"2023100615123182669_j_jpem-2023-0183_ref_006","doi-asserted-by":"crossref","unstructured":"Velasco, PJ, Manshadi, M, Breen, K, Lippmann, S. Psychiatric aspects of parathyroid disease. Psychosomatics 1999;40:486\u201390. https:\/\/doi.org\/10.1016\/s0033-3182(99)71186-2.","DOI":"10.1016\/S0033-3182(99)71186-2"},{"key":"2023100615123182669_j_jpem-2023-0183_ref_007","doi-asserted-by":"crossref","unstructured":"Cooper, MS, Gittoes, NJ. Diagnosis and management of hypocalcaemia. BMJ 2008;336:1298\u2013302. https:\/\/doi.org\/10.1136\/bmj.39582.589433.be.","DOI":"10.1136\/bmj.39582.589433.BE"},{"key":"2023100615123182669_j_jpem-2023-0183_ref_008","doi-asserted-by":"crossref","unstructured":"Trochoutsou, AI, Kloukina, V, Samitas, K, Xanthou, G. Vitamin-D in the immune system: genomic and non-genomic actions. Mini Rev Med Chem 2015;15:953\u201363. https:\/\/doi.org\/10.2174\/1389557515666150519110830.","DOI":"10.2174\/1389557515666150519110830"},{"key":"2023100615123182669_j_jpem-2023-0183_ref_009","doi-asserted-by":"crossref","unstructured":"Kouvari, M, Panagiotakos, DB, Chrysohoou, C, Yannakoulia, M, Georgousopoulou, EN, Tousoulis, D, et al.. Dietary vitamin D intake, cardiovascular disease and cardiometabolic risk factors: a sex-based analysis from the ATTICA cohort study. J Hum Nutr Diet 2020;33:708\u201317. https:\/\/doi.org\/10.1111\/jhn.12748.","DOI":"10.1111\/jhn.12748"},{"key":"2023100615123182669_j_jpem-2023-0183_ref_010","doi-asserted-by":"crossref","unstructured":"Akter, R, Afrose, A, Sharmin, S, Rezwan, R, Rahman, MR, Neelotpol, S. A\u00a0comprehensive look into the association of vitamin D levels and vitamin D receptor gene polymorphism with obesity in children. Biomed Pharmacother 2022;153:113285. https:\/\/doi.org\/10.1016\/j.biopha.2022.113285.","DOI":"10.1016\/j.biopha.2022.113285"},{"key":"2023100615123182669_j_jpem-2023-0183_ref_011","doi-asserted-by":"crossref","unstructured":"Falak, S, Aftab, L, Saeed, M, Islam, A. Prevalence of Vitamin-D deficiency is related to severity of liver damage in Hepatitis-C patients. Pak J Med Sci 2020;36:445\u201350. https:\/\/doi.org\/10.12669\/pjms.36.3.1490.","DOI":"10.12669\/pjms.36.3.1490"},{"key":"2023100615123182669_j_jpem-2023-0183_ref_012","doi-asserted-by":"crossref","unstructured":"Rasoul, MA, Al-Mahdi, M, Al-Kandari, H, Dhaunsi, GS, Haider, MZ. Low serum vitamin-D status is associated with high prevalence and early onset of type-1 diabetes mellitus in Kuwaiti children. BMC Pediatr 2016;16:95. https:\/\/doi.org\/10.1186\/s12887-016-0629-3.","DOI":"10.1186\/s12887-016-0629-3"},{"key":"2023100615123182669_j_jpem-2023-0183_ref_013","doi-asserted-by":"crossref","unstructured":"Carmeliet, G, Dermauw, V, Bouillon, R. Vitamin D signaling in calcium and bone homeostasis: a delicate balance. Best Pract Res Clin Endocrinol Metab 2015;29:621\u201331. https:\/\/doi.org\/10.1016\/j.beem.2015.06.001.","DOI":"10.1016\/j.beem.2015.06.001"},{"key":"2023100615123182669_j_jpem-2023-0183_ref_014","doi-asserted-by":"crossref","unstructured":"Y\u0131lmaz, B, Ayg\u00fcn, C, \u00c7etino\u011flu, E. Vitamin D levels in newborns and association with neonatal hypocalcemia. J Matern Fetal Neonatal Med 2018;31:1889\u201393. https:\/\/doi.org\/10.1080\/14767058.2017.1331430.","DOI":"10.1080\/14767058.2017.1331430"},{"key":"2023100615123182669_j_jpem-2023-0183_ref_015","doi-asserted-by":"crossref","unstructured":"Do, HJ, Park, JS, Seo, JH, Lee, ES, Park, CH, Woo, HO, et al.. Neonatal late-onset hypocalcemia: is there any relationship with maternal hypovitaminosis D? Pediatr Gastroenterol Hepatol Nutr 2014;17:47\u201351. https:\/\/doi.org\/10.5223\/pghn.2014.17.1.47.","DOI":"10.5223\/pghn.2014.17.1.47"},{"key":"2023100615123182669_j_jpem-2023-0183_ref_016","doi-asserted-by":"crossref","unstructured":"Haarburger, D, Hoffman, M, Erasmus, RT, Pillay, TS. Relationship between vitamin D, calcium and parathyroid hormone in Cape Town. J Clin Pathol 2009;62:567\u20139. https:\/\/doi.org\/10.1136\/jcp.2008.062877.","DOI":"10.1136\/jcp.2008.062877"},{"key":"2023100615123182669_j_jpem-2023-0183_ref_017","doi-asserted-by":"crossref","unstructured":"Czech-Kowalska, J, Pludowski, P, Dobrzanska, A, Kryskiewicz, E, Karczmarewicz, E, Gruszfeld, D, et al.. Impact of vitamin D supplementation on markers of bone mineral metabolism in term infants. Bone 2012;51:781\u20136. https:\/\/doi.org\/10.1016\/j.bone.2012.06.023.","DOI":"10.1016\/j.bone.2012.06.023"},{"key":"2023100615123182669_j_jpem-2023-0183_ref_018","doi-asserted-by":"crossref","unstructured":"Brooke, OG, Brown, IR, Cleeve, HJ, Sood, A. Observations on the vitamin D state of pregnant Asian women in London. Br J Obstet Gynaecol 1981;88:18\u201326. https:\/\/doi.org\/10.1111\/j.1471-0528.1981.tb00931.x.","DOI":"10.1111\/j.1471-0528.1981.tb00931.x"},{"key":"2023100615123182669_j_jpem-2023-0183_ref_019","doi-asserted-by":"crossref","unstructured":"Taha, SA, Dost, SM, Sedrani, SH. 25-Hydroxyvitamin D and total calcium: extraordinarily low plasma concentrations in Saudi mothers and their neonates. Pediatr Res 1984;18:739\u201341. https:\/\/doi.org\/10.1203\/00006450-198408000-00013.","DOI":"10.1203\/00006450-198408000-00013"},{"key":"2023100615123182669_j_jpem-2023-0183_ref_020","doi-asserted-by":"crossref","unstructured":"Mosayebi, Z, Sagheb, S, Mirzendedel, M, Movahedian, AH. Serum vitamin D deficiency in NICU hospitalized neonates and its association with neonatal outcomes. J Fam Reprod Health 2021;15:99\u2013105. https:\/\/doi.org\/10.18502\/jfrh.v15i2.6450.","DOI":"10.18502\/jfrh.v15i2.6450"},{"key":"2023100615123182669_j_jpem-2023-0183_ref_021","doi-asserted-by":"crossref","unstructured":"Martinez, ME, Catal\u00e1n, P, Balaguer, G, Lisbona, A, Quero, J, Reque, A, et al.. 25(OH)D levels in diabetic pregnancies relation with neonatal hypocalcemia. Horm Metab Res 1991;23:38\u201341. https:\/\/doi.org\/10.1055\/s-2007-1003606.","DOI":"10.1055\/s-2007-1003606"},{"key":"2023100615123182669_j_jpem-2023-0183_ref_022","doi-asserted-by":"crossref","unstructured":"Wang, H, Du, Y, Wu, Z, Geng, H, Zhu, X, Zhu, X. Serum vitamin D insufficiency in hospitalized full-term neonates at a tertiary hospital in eastern China. Front Pediatr 2022;10:878992. https:\/\/doi.org\/10.3389\/fped.2022.878992.","DOI":"10.3389\/fped.2022.878992"},{"key":"2023100615123182669_j_jpem-2023-0183_ref_023","doi-asserted-by":"crossref","unstructured":"Kozgar, SAM, Chay, P, Munns, CF. Screening of vitamin D and calcium concentrations in neonates of mothers at high risk of vitamin D deficiency. BMC Pediatr 2020;20:332. https:\/\/doi.org\/10.1186\/s12887-020-02204-8.","DOI":"10.1186\/s12887-020-02204-8"},{"key":"2023100615123182669_j_jpem-2023-0183_ref_024","doi-asserted-by":"crossref","unstructured":"Nagendra, N, Chhina, AS, Shenoi, P, Shenoi, A, Bhattacharya, M, Kumar, RK. Observational study of third-trimester vitamin D3 supplementation and implications for mothers and neonates at term. J Obstet Gynaecol India 2019;69:S89\u201394. https:\/\/doi.org\/10.1007\/s13224-018-1095-7.","DOI":"10.1007\/s13224-018-1095-7"},{"key":"2023100615123182669_j_jpem-2023-0183_ref_025","doi-asserted-by":"crossref","unstructured":"Chacham, S, Rajput, S, Gurnurkar, S, Mirza, A, Saxena, V, Dakshinamurthy, S, et al.. Prevalence of vitamin D deficiency among infants in northern India: a hospital based prospective study. Cureus 2020;12:e11353. https:\/\/doi.org\/10.7759\/cureus.11353.","DOI":"10.7759\/cureus.11353"},{"key":"2023100615123182669_j_jpem-2023-0183_ref_026","doi-asserted-by":"crossref","unstructured":"Holick, MF. Vitamin D deficiency. N Engl J Med 2007;357:266\u201381. https:\/\/doi.org\/10.1056\/nejmra070553.","DOI":"10.1056\/NEJMra070553"},{"key":"2023100615123182669_j_jpem-2023-0183_ref_027","doi-asserted-by":"crossref","unstructured":"Ncayiyana, JR, Martinez, L, Goddard, E, Myer, L, Zar, HJ. Prevalence and correlates of vitamin D deficiency among young South African infants: a\u00a0birth cohort study. Nutrients 2021;13:1500. https:\/\/doi.org\/10.3390\/nu13051500.","DOI":"10.3390\/nu13051500"},{"key":"2023100615123182669_j_jpem-2023-0183_ref_028","unstructured":"Liu, R, Wu, H, Chen, Y, Xiong, F, Zhao, J, Sun, H, et al.. Prevalence of vitamin A and vitamin D deficiency in hospitalized neonates in Xi\u2019an, China. Asia Pac J Clin Nutr 2022;31:275\u201381. https:\/\/doi.org\/10.6133\/apjcn.202206_31(2).0013."},{"key":"2023100615123182669_j_jpem-2023-0183_ref_029","unstructured":"Balasubramanian, S, Ganesh, R. Vitamin D deficiency in exclusively breast-fed infants. Indian J Med Res 2008;127:250\u20135."},{"key":"2023100615123182669_j_jpem-2023-0183_ref_030","doi-asserted-by":"crossref","unstructured":"Ahmed, I, Atiq, M, Iqbal, J, Khurshid, M, Whittaker, P. Vitamin D deficiency rickets in breast-fed infants presenting with hypocalcaemic seizures. Acta Paediatr 1995;84:941\u20132. https:\/\/doi.org\/10.1111\/j.1651-2227.1995.tb13798.x.","DOI":"10.1111\/j.1651-2227.1995.tb13798.x"},{"key":"2023100615123182669_j_jpem-2023-0183_ref_031","doi-asserted-by":"crossref","unstructured":"Holmes, VA, Barnes, MS, Alexander, HD, McFaul, P, Wallace, JM. Vitamin D deficiency and insufficiency in pregnant women: a longitudinal study. Br J Nutr 2009;102:876\u201381. https:\/\/doi.org\/10.1017\/s0007114509297236.","DOI":"10.1017\/S0007114509297236"},{"key":"2023100615123182669_j_jpem-2023-0183_ref_032","doi-asserted-by":"crossref","unstructured":"Karras, SN, Koufakis, T, Antonopoulou, V, Goulis, DG, Alayl\u0131o\u011flu, M, Dursun, E, et al.. Vitamin D receptor Fokl polymorphism is a determinant of both maternal and neonatal vitamin D concentrations at birth. J\u00a0Steroid Biochem Mol Biol 2020;199:105568. https:\/\/doi.org\/10.1016\/j.jsbmb.2019.105568.","DOI":"10.1016\/j.jsbmb.2019.105568"},{"key":"2023100615123182669_j_jpem-2023-0183_ref_033","doi-asserted-by":"crossref","unstructured":"Karras, SN, Koufakis, T, Antonopoulou, V, Goulis, DG, Annweiler, C, Pilz, S, et al.. Characterizing neonatal vitamin D deficiency in the modern era: a\u00a0maternal-neonatal birth cohort from Southern Europe. J Steroid Biochem Mol Biol 2020;198:105555. https:\/\/doi.org\/10.1016\/j.jsbmb.2019.105555.","DOI":"10.1016\/j.jsbmb.2019.105555"},{"key":"2023100615123182669_j_jpem-2023-0183_ref_034","doi-asserted-by":"crossref","unstructured":"Jain, A, Agarwal, R, Sankar, MJ, Deorari, A, Paul, VK. Hypocalcemia in the newborn. Indian J Pediatr 2010;77:1123\u20138. https:\/\/doi.org\/10.1007\/s12098-010-0176-0.","DOI":"10.1007\/s12098-010-0176-0"},{"key":"2023100615123182669_j_jpem-2023-0183_ref_035","doi-asserted-by":"crossref","unstructured":"Karras, SN, Wagner, CL, Castracane, VD. Understanding vitamin D metabolism in pregnancy: from physiology to pathophysiology and clinical outcomes. Metabolism 2018;86:112\u201323. https:\/\/doi.org\/10.1016\/j.metabol.2017.10.001.","DOI":"10.1016\/j.metabol.2017.10.001"},{"key":"2023100615123182669_j_jpem-2023-0183_ref_036","doi-asserted-by":"crossref","unstructured":"Fink, C, Peters, RL, Koplin, JJ, Brown, J, Allen, KJ. Factors affecting vitamin D status in infants. Children 2019;6:7. https:\/\/doi.org\/10.3390\/children6010007.","DOI":"10.3390\/children6010007"}],"container-title":["Journal of Pediatric Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2023-0183\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2023-0183\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T15:12:45Z","timestamp":1696605165000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2023-0183\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,28]]},"references-count":36,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,8,28]]},"published-print":{"date-parts":[[2023,10,26]]}},"alternative-id":["10.1515\/jpem-2023-0183"],"URL":"https:\/\/doi.org\/10.1515\/jpem-2023-0183","relation":{},"ISSN":["0334-018X","2191-0251"],"issn-type":[{"value":"0334-018X","type":"print"},{"value":"2191-0251","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,28]]}}}