{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:10:51Z","timestamp":1790892651888,"version":"4.1.0"},"reference-count":25,"publisher":"Walter de Gruyter GmbH","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2023-0203_abs_002\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>We aimed to assess the efficacy of oral use of oral desamino-D-arginine-8-vasopressin lyophilisate (OLD) in children with central diabetes insipidus (CDI).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2023-0203_abs_003\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Clinical, laboratory, and imaging characteristics of twenty-five children with CDI treated with OLD were evaluated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2023-0203_abs_004\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Fourteen boys and eleven girls with a mean age of 52.37\u202fmonths were evaluated. These children (mean weight and height at admission, 26.81\u00a0\u00b1\u00a014.8\u202fkg vs. 92.52\u00a0\u00b1\u00a030\u202fcm) presented with failure to thrive, irritability, prolonged fever, polyuria and hypernatremia (mean sodium level, 143.12\u00a0\u00b1\u00a08.6\u202fmEq\/L). At the time of hypernatremia, mean serum and urine osmolality were 298.2\u00a0\u00b1\u00a018\u202fmOsm\/kg and 160.20\u00a0\u00b1\u00a08.7\u202fmOsm\/kg, respectively. ADH levels were undetectable (&lt;0.5\u202fpmol\/L) at admission in all cases. Oral administration of desmopressin lyophilisate (120\u202f\u00b5g\/tablet) was initiated at a dose of 5\u202f\u03bcg\/kg\/day in two divided doses together with controlled water intake to avoid hyponatremia. Serum sodium levels normalised in a mean duration\u00a0of 15.2\u00a0\u00b1\u00a016.4\u202fh with a mean decline rate of 0.12\u00a0\u00b1\u00a00.04\u202fmEq\/L\/h. Nine children needed rehospitalization because of hypernatremia due to non-compliance. Four episode of hyponatremia was observed. Weight gain and growth were normal during the mean follow-up duration of 37.79\u00a0\u00b1\u00a048.2\u202fmonths.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2023-0203_abs_005\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Administration of OLD was practical and safe in the treatment of CDI in children with CNS malformations in this small retrospective series.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2023-0203","type":"journal-article","created":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T11:20:28Z","timestamp":1693653628000},"page":"925-929","source":"Crossref","is-referenced-by-count":1,"title":["The therapeutic effect of oral desmopressin lyophilisate formulation in children with central diabetes insipidus"],"prefix":"10.1515","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5800-9014","authenticated-orcid":false,"given":"H\u00fcseyin An\u0131l","family":"Korkmaz","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Endocrinology , Dr. Beh\u00e7et Uz Pediatric Diseases and Surgery Training and Research Hospital , \u0130zmir , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0021-6154","authenticated-orcid":false,"given":"Fulya","family":"Co\u015fkunol","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Dr. Beh\u00e7et Uz Pediatric Diseases and Surgery Training and Research Hospital , \u0130zmir , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1100-6961","authenticated-orcid":false,"given":"Vatan","family":"Bar\u0131\u015f\u0131k","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine , Izmir Tepecik Training and Research Hospital , Izmir , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9153-8409","authenticated-orcid":false,"given":"Behzat","family":"Ozkan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Endocrinology , Dr. Beh\u00e7et Uz Pediatric Diseases and Surgery Training and Research Hospital , \u0130zmir , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2023,9,4]]},"reference":[{"key":"2023100615123196183_j_jpem-2023-0203_ref_001","doi-asserted-by":"crossref","unstructured":"Patti, G, Ibba, A, Morana, G, Napoli, F, Fava, D, di Iorgi, N, et al.. 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