{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T03:49:30Z","timestamp":1780372170470,"version":"3.54.1"},"reference-count":31,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T00:00:00Z","timestamp":1699574400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"National Research, Development and Innovation Fund of Hungary","award":["2020-4.1.1-TKP2020"],"award-info":[{"award-number":["2020-4.1.1-TKP2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2023-0315_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The association between obesity and gastroesophageal reflux disease (GERD) is well-established in adults; however, data in pediatric population is scarce. Our study aimed to assess the association between GERD and health-related quality of life (HRQoL) in overweight children.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2023-0315_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>From April to August of 2020, we included children aged 7\u201318 years who attended the Endocrinological Outpatient Clinic at the Paediatric Institute, University of Debrecen, Hungary. The participants completed two questionnaires: the Pediatric Gastroesophageal Reflux Disease Symptom Questionnaire (PGSQ) and the HRQoL questionnaire (PedsQL). Based on the criteria of the World Health Organization (WHO), the patients were categorized into two groups: an overweight or obese group and a group with normal weight.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2023-0315_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 107 children (51\u202f% female, mean age 13.2 years, 46\u202f% overweight or obese) completed the questionnaires. The median PGSQ score was similar in both groups (4.0 (IQR: 1.0\u20137.8) vs. 3.0 (IQR: 1.0\u20137.0), p=0.6). However, the total PedsQL score was significantly lower in the children with overweight or obesity compared to those with normal weight (80.1 (71.1\u201391.0) vs. 88.0 (76.1\u201394.6), p=0.031). The PedsQL score was lower among overweight patients with GERD symptoms than that of normal-weight patients without GERD symptoms.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2023-0315_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our findings highlight the importance of raising awareness about GERD to enhance the HRQoL and prevent long-term complications in obese children.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2023-0315","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T09:54:50Z","timestamp":1699523690000},"page":"27-32","source":"Crossref","is-referenced-by-count":5,"title":["Health related quality of life is associated with gastroesophageal reflux symptoms in overweight children"],"prefix":"10.1515","volume":"37","author":[{"given":"Zita","family":"Andr\u00e1sdi","sequence":"first","affiliation":[{"name":"Heim P\u00e1l National Pediatric Institute , Budapest , Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katalin E.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Heim P\u00e1l National Pediatric Institute , Budapest , Hungary"},{"name":"Department of Family Care, Faculty of Health Sciences , Semmelweis University , Budapest , Hungary"},{"name":"Institute for Translational Medicine, Medical School , University of P\u00e9cs , P\u00e9cs , Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsanna","family":"Ga\u00e1l","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine , University of Debrecen , Debrecen , Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9va","family":"Nemes","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine , University of Debrecen , Debrecen , Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enik\u0151","family":"Felszeghy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine , University of Debrecen , Debrecen , Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2023,11,10]]},"reference":[{"key":"2024010910115261327_j_jpem-2023-0315_ref_001","doi-asserted-by":"crossref","unstructured":"Hampel, H, Abraham, NS, El-Serag, HB. Meta-analysis: obesity and the risk for gastroesophageal reflux disease and its complications. Ann Intern Med 2005;143:199\u2013211. https:\/\/doi.org\/10.7326\/0003-4819-143-3-200508020-00006.","DOI":"10.7326\/0003-4819-143-3-200508020-00006"},{"key":"2024010910115261327_j_jpem-2023-0315_ref_002","doi-asserted-by":"crossref","unstructured":"Corley, DA, Kubo, A. Body mass index and gastroesophageal reflux disease: a systematic review and meta-analysis. Am J Gastroenterol 2006;101:2619\u201328. https:\/\/doi.org\/10.1111\/j.1572-0241.2006.00849.x.","DOI":"10.1111\/j.1572-0241.2006.00849.x"},{"key":"2024010910115261327_j_jpem-2023-0315_ref_003","doi-asserted-by":"crossref","unstructured":"Nandurkar, S, Locke, GR3rd, Fett, S, Zinsmeister, AR, Cameron, AJ, Talley, NJ. Relationship between body mass index, diet, exercise and gastro-oesophageal reflux symptoms in a community. 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