{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T17:54:29Z","timestamp":1740160469767,"version":"3.37.3"},"reference-count":41,"publisher":"Walter de Gruyter GmbH","issue":"10","funder":[{"DOI":"10.13039\/100007776","name":"Deanship of Academic Research, University of Jordan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007776","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2023-0322_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To investigate the prevalence of thyroid autoimmunity and related thyroid disorders among children and adolescents with type 1 diabetes in Jordan.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2023-0322_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In a retrospective study, thyroid stimulating hormone and thyroid hormone (Free T4) levels were measured in 684 children with type 1 diabetes who presented to Jordan University Hospital between January 2012 and February 2021. Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TGAb) antibodies were measured in 526 and 438 subjects with type 1 diabetes, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2023-0322_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>681 children were included in the study (52.4\u202f% females, average current age 14.3 years, average age at diagnosis 8.0 years, and average diabetes duration 6.2 years). Of the whole group, 18 children (2.6\u202f%) were diagnosed with subclinical hypothyroidism and 31 children (4.4\u202f%) had overt hypothyroidism. Of those who were tested for TPOAb and TGAb, 22.6 and 23.1\u202f% were positive respectively. Predictors for developing hypothyroidism were female sex and positive antibodies to glutamic acid decarboxylase.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2023-0322_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Screening for associated thyroid autoimmunity in children and adolescents with type one diabetes from Jordan is advised with a special focus on females and those with positive antibodies to glutamic acid decarboxylase.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2023-0322","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T13:31:26Z","timestamp":1693575086000},"page":"917-924","source":"Crossref","is-referenced-by-count":0,"title":["Associated autoimmune thyroid diseases in children and adolescents with type one diabetes in Jordan"],"prefix":"10.1515","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8419-0547","authenticated-orcid":false,"given":"Rasha","family":"Odeh","sequence":"first","affiliation":[{"name":"Department of Pediatrics , School of Medicine, University of Jordan , Amman , Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7490-5465","authenticated-orcid":false,"given":"Lobna","family":"Gharaibeh","sequence":"additional","affiliation":[{"name":"Pharmacological and Diagnostic Research Center , Faculty of Pharmacy, AI-Ahliyya Amman University , Amman , Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7306-5647","authenticated-orcid":false,"given":"Sarah","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , School of Medicine, University of Jordan , Amman , Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8634-8611","authenticated-orcid":false,"given":"Abeer","family":"Alassaf","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , School of Medicine, University of Jordan , Amman , Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2023,9,4]]},"reference":[{"key":"2023100615123187277_j_jpem-2023-0322_ref_001","doi-asserted-by":"crossref","unstructured":"Mayer-davis, EJ, Dabelea, D, Kahkoska, AR, Jefferies, C, Balde, N, Gong, CX, et al.. 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