{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T08:56:02Z","timestamp":1788339362019,"version":"build-2803163510"},"reference-count":30,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2023-0381_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Investigate serum vitamin D (vit D) levels\u2019 relation to uterine volume in idiopathic central precocious puberty (ICPP) girls and compare findings with normal peers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2023-0381_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Analyzed 278 ICPP cases from January 2017 to September 2022 alongside 239 normally developing girls. Collected clinical data and lab markers and performed subgroup analysis based on vit D levels. Correlation and regression analyses were conducted.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2023-0381_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The ICPP group exhibited elevated uterine volume and lower serum vit D compared to controls (p&lt;0.05). A weak negative correlation was noted between vit D and uterine volume in ICPP (r=\u22120.193, p=0.004), and no such correlation in controls (r=\u22120.073, p=0.319). The ICPP vit D deficiency subgroup displayed higher uterine volume than the insufficiency and sufficiency subgroups (p&lt;0.05). Uterine volume in the insufficiency subgroup exceeded the sufficiency subgroup (p&lt;0.05). After adjusting for confounders, lower vit D is linked to increased ICPP uterine volume (non-standardized regression coefficient \u03b2=\u221225.55, 95\u202f% CI=\u00a0\u221246.23,\u00a0\u22124.87, p=0.016). A Limited correlation between vit D and uterine volume was seen in girls with normal pubertal timing.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2023-0381_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We demonstrated a correlation between vit D and uterine volume in ICPP girls, absent in normal peers. ICPP girls often exhibit lower vit D levels and increased uterine volume. Further research is vital for understanding vit D\u2019s role in ICPP pathogenesis and guiding prevention and treatment strategies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2023-0381","type":"journal-article","created":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T01:01:05Z","timestamp":1703034065000},"page":"144-149","source":"Crossref","is-referenced-by-count":7,"title":["Correlation between serum vitamin D level and uterine volume in girls with idiopathic central precocious puberty"],"prefix":"10.1515","volume":"37","author":[{"given":"Jun","family":"Sun","sequence":"first","affiliation":[{"name":"The Third Affiliated Hospital of Zhengzhou University , Zhengzhou , Henan Province , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"The Third Affiliated Hospital of Zhengzhou University , Zhengzhou , Henan Province , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Xiao","sequence":"additional","affiliation":[{"name":"The Third Affiliated Hospital of Zhengzhou University , Zhengzhou , Henan Province , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niu-niu","family":"Cao","sequence":"additional","affiliation":[{"name":"The Third Affiliated Hospital of Zhengzhou University , Zhengzhou , Henan Province , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-fan","family":"Wang","sequence":"additional","affiliation":[{"name":"The Third Affiliated Hospital of Zhengzhou University , Zhengzhou , Henan Province , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-ru","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Third Affiliated Hospital of Zhengzhou University , Zhengzhou , Henan Province , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-qin","family":"Jiang","sequence":"additional","affiliation":[{"name":"The Third Affiliated Hospital of Zhengzhou University , Zhengzhou , Henan Province , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2023,12,21]]},"reference":[{"key":"2024021417134794308_j_jpem-2023-0381_ref_001","doi-asserted-by":"crossref","unstructured":"Bhan, I. Vitamin d binding protein and bone health. Int J Endocrinol 2014;2014:561214. https:\/\/doi.org\/10.1155\/2014\/561214.","DOI":"10.1155\/2014\/561214"},{"key":"2024021417134794308_j_jpem-2023-0381_ref_002","doi-asserted-by":"crossref","unstructured":"Lopez, AG, Kerlan, V, Desailloud, R. Non-classical effects of vitamin D: non-bone effects of vitamin D. 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