{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:15:29Z","timestamp":1792494929196,"version":"4.5.0"},"reference-count":47,"publisher":"Walter de Gruyter GmbH","issue":"4","funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jpem-2023-0420_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      This prospective multicenter study aimed (1) to examine changes in parent-reported health-related quality of life (HRQOL) of children with short stature and the effects of the children\u2019s condition on parents themselves within the first year of human growth hormone (hGH) treatment and (2) to predict\n                      <jats:italic>effects on parents<\/jats:italic>\n                      based on main and interaction effects of children\u2019s HRQOL and increase in height.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2023-0420_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 110 parents of children aged 4\u201318 years, diagnosed with idiopathic growth hormone deficiency, small for gestational age, or idiopathic short stature, were recruited from 11 participating German pediatric endocrinologists and asked to fill out the short stature-specific Quality of Life in Short Stature Youth (QoLISSY) Questionnaire before hGH treatment was initiated and one year later.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2023-0420_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Negative effects of the children\u2019s short stature on the parents decrease over time, independent of diagnosis and treatment status. Furthermore, treatment status and height increase moderated the links between children\u2019s improved HRQOL as perceived by their parents and decreased caregiving burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2023-0420_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Based on the children\u2019s improved HRQOL and the parent\u2019s decrease in caregiving burden, patient-reported outcomes that consider parental and child\u2019s perspectives should be considered when deciding on hGH treatment for children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jpem-2023-0420","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T05:49:22Z","timestamp":1709185762000},"page":"326-335","source":"Crossref","is-referenced-by-count":4,"title":["Growth hormone treatment in children with short stature: impact of the diagnosis on parents"],"prefix":"10.1515","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6143-7594","authenticated-orcid":false,"given":"Stefanie","family":"Witt","sequence":"first","affiliation":[{"name":"Department of Medical Psychology, Center for Psychosocial Medicine , 37734 University Medical Center Hamburg-Eppendorf , Hamburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janika","family":"Bloemeke","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology, Center for Psychosocial Medicine , 37734 University Medical Center Hamburg-Eppendorf , Hamburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8876-0159","authenticated-orcid":false,"given":"Monika","family":"Bullinger","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology, Center for Psychosocial Medicine , 37734 University Medical Center Hamburg-Eppendorf , Hamburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmuth-G\u00fcnther","family":"D\u00f6rr","sequence":"additional","affiliation":[{"name":"Clinic for Children and Adolescents , 27168 Erlangen-N\u00fcrnberg Universtiy , Erlangen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4110-9961","authenticated-orcid":false,"given":"Neuza","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology, Center for Psychosocial Medicine , 37734 University Medical Center Hamburg-Eppendorf , Hamburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7920-2339","authenticated-orcid":false,"given":"Julia Hannah","family":"Quitmann","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology, Center for Psychosocial Medicine , 37734 University Medical Center Hamburg-Eppendorf , Hamburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2024,3,1]]},"reference":[{"key":"2026051215131287815_j_jpem-2023-0420_ref_001","unstructured":"Bettendorf, M, Kiepe, D, Knauer-Fischer, S, W\u00f6lfle, J. 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