{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T20:20:37Z","timestamp":1776889237789,"version":"3.51.2"},"reference-count":10,"publisher":"Walter de Gruyter GmbH","issue":"7","funder":[{"name":"the National Key R&D Program of China","award":["no. 2018YFC1002404"],"award-info":[{"award-number":["no. 2018YFC1002404"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2024-0005_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To analyze and summarize the clinical characteristics and treatment of juvenile patients with type 1 diabetes mellitus (T1DM) complicated by early cataract.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2024-0005_abs_002\">\n                  <jats:title>Case presentation<\/jats:title>\n                  <jats:p>This retrospective study collected clinical data from 210 children and adolescents newly diagnosed with T1DM who were admitted to the Department of Pediatrics, Tongji Hospital (Wuhan) between 2015 and 2022. Among 210 patients with T1DM, early cataract developed within 3\u00a0months before diabetes onset and 12\u00a0months thereafter in 2 (0.95\u202f%) patients. The two patients were both females, aged 13 and 9 years, respectively. In both cases, cataracts in both eyes appeared in the early stages of T1DM, showing a short course and rapid development. After intensive insulin treatment for stringent and stable blood glucose control, one patient underwent cataract extraction with significant improvement, and her visual acuity returned to normal. The other patient received intensive insulin therapy and insulin pump therapy for 8 years. Subsequently, she underwent cataract surgery after achieving stable blood glucose levels, without complete recovery of vision.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2024-0005_abs_003\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Cataract is a rare complication in the early stages of T1DM in children and adolescents. Ophthalmic surgery is the preferred treatment for patients with diabetic cataract after achieving stable glycemic control, which may help prevent visual impairment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2024-0005","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T11:26:04Z","timestamp":1717068364000},"page":"652-656","source":"Crossref","is-referenced-by-count":2,"title":["Early juvenile cataract in newly diagnosed type 1 diabetic patients: a description of two cases"],"prefix":"10.1515","volume":"37","author":[{"given":"Shimin","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Tongji Hospital, Tongji Medical College , 12443 Huazhong University of Science and Technology , Wuhan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqin","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tongji Hospital, Tongji Medical College , Huazhong University of Science and Technology , Wuhan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Tongji Hospital, Tongji Medical College , 12443 Huazhong University of Science and Technology , Wuhan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Tongji Hospital, Tongji Medical College , 12443 Huazhong University of Science and Technology , Wuhan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Tongji Hospital, Tongji Medical College , 12443 Huazhong University of Science and Technology , Wuhan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoping","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Tongji Hospital, Tongji Medical College , 12443 Huazhong University of Science and Technology , Wuhan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2024,5,31]]},"reference":[{"key":"2024071118565840056_j_jpem-2024-0005_ref_001","doi-asserted-by":"crossref","unstructured":"Reiter, UM, Eckert, AJ, Dunstheimer, D, Bechtold-Dalla Pozza, S, L\u00fcllwitz, C, Golembowski, S, et al.. Cataract in children and adolescents with type 1 diabetes. Insights from the German\/Austrian DPV registry. Pediatr Diabetes 2022;23:362\u20139. https:\/\/doi.org\/10.1111\/pedi.13316.","DOI":"10.1111\/pedi.13316"},{"key":"2024071118565840056_j_jpem-2024-0005_ref_002","doi-asserted-by":"crossref","unstructured":"\u0160imunovi\u0107, M, Parad\u017eik, M, \u0160krabi\u0107, R, Uni\u0107, I, Bu\u0107an, K, \u0160krabi\u0107, V. Cataract as early ocular complication in children and adolescents with type 1 diabetes mellitus. Internet J Endocrinol 2018;2018:6763586. https:\/\/doi.org\/10.1155\/2018\/6763586.","DOI":"10.1155\/2018\/6763586"},{"key":"2024071118565840056_j_jpem-2024-0005_ref_003","doi-asserted-by":"crossref","unstructured":"Obrosova, IG, Chung, SSM, Kador, PF. Diabetic cataracts: mechanisms and management. Diabetes Metab Res Rev 2010;26:172\u201380. https:\/\/doi.org\/10.1002\/dmrr.1075.","DOI":"10.1002\/dmrr.1075"},{"key":"2024071118565840056_j_jpem-2024-0005_ref_004","doi-asserted-by":"crossref","unstructured":"Gregory, GA, Robinson, TIG, Linklater, SE, Wang, F, Colagiuri, S, de Beaufort, C, et al.. Global incidence, prevalence, and mortality of type 1 diabetes in 2021 with projection to 2040: a modelling study. Lancet Diabetes Endocrinol 2022;10:741\u201360. https:\/\/doi.org\/10.1016\/s2213-8587(22)00218-2.","DOI":"10.1016\/S2213-8587(22)00218-2"},{"key":"2024071118565840056_j_jpem-2024-0005_ref_005","doi-asserted-by":"crossref","unstructured":"Weng, J, Zhou, Z, Guo, L, Zhu, D, Ji, L, Luo, X, et al.. Incidence of type 1 diabetes in China, 2010-13: population based study. BMJ 2018;360:j5295. https:\/\/doi.org\/10.1136\/bmj.j5295. Published 2018 Jan 3.","DOI":"10.1136\/bmj.j5295"},{"key":"2024071118565840056_j_jpem-2024-0005_ref_006","doi-asserted-by":"crossref","unstructured":"Lu, WL, Shen, PC, Lee, CH, Su, YT, Chen, LM. High risk of early cataracts in young type 1 diabetes group: a nationwide cohort study. Internet J Endocrinol 2020;2020:8160256. https:\/\/doi.org\/10.1155\/2020\/8160256. Published 2020 Oct 9.","DOI":"10.1155\/2020\/8160256"},{"key":"2024071118565840056_j_jpem-2024-0005_ref_007","doi-asserted-by":"crossref","unstructured":"Wilson, MEJ, Levin, AV, Trivedi, RH, Kruger, SJ, Elliott, LA, Ainsworth, JR, et al.. Cataract associated with type-1 diabetes mellitus in the pediatric population. J AAPOS 2007;11:162\u20135. https:\/\/doi.org\/10.1016\/j.jaapos.2005.10.005.","DOI":"10.1016\/j.jaapos.2005.10.005"},{"key":"2024071118565840056_j_jpem-2024-0005_ref_008","doi-asserted-by":"crossref","unstructured":"Taskapili, M, Gulkilik, G, Ozsutcu, M, Kucuksahin, H. Acute bilateral dense cortical cataracts as a first manifestation of juvenile diabetes mellitus in a 12-year-old girl. J Pediatr Ophthalmol Strabismus 2008;45:177\u20138. https:\/\/doi.org\/10.3928\/01913913-20080501-20.","DOI":"10.3928\/01913913-20080501-20"},{"key":"2024071118565840056_j_jpem-2024-0005_ref_009","doi-asserted-by":"crossref","unstructured":"Iafusco, D, Prisco, F, Romano, MR, Dell\u2019omo, R, Libondi, T, Costagliola, C. Acute juvenile cataract in newly diagnosed type 1 diabetic patients: a description of six cases. Pediatr Diabetes 2011;12:642\u20138. https:\/\/doi.org\/10.1111\/j.1399-5448.2010.00749.x.","DOI":"10.1111\/j.1399-5448.2010.00749.x"},{"key":"2024071118565840056_j_jpem-2024-0005_ref_010","unstructured":"Jin, YY, Huang, K, Zou, CC, Liang, L, Wang, XM, Jin, J. Reversible cataract as the presenting sign of diabetes mellitus: report of two cases and literature review. Iran J Pediatr (Engl Ed) 2012;22:125\u20138."}],"container-title":["Journal of Pediatric Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2024-0005\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2024-0005\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T18:57:16Z","timestamp":1720724236000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2024-0005\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,31]]},"references-count":10,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,5,31]]},"published-print":{"date-parts":[[2024,7,26]]}},"alternative-id":["10.1515\/jpem-2024-0005"],"URL":"https:\/\/doi.org\/10.1515\/jpem-2024-0005","relation":{},"ISSN":["0334-018X","2191-0251"],"issn-type":[{"value":"0334-018X","type":"print"},{"value":"2191-0251","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,31]]}}}