{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:49:19Z","timestamp":1747198159379,"version":"3.40.5"},"reference-count":12,"publisher":"Walter de Gruyter GmbH","issue":"5","license":[{"start":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:00:00Z","timestamp":1713139200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2024-0019_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Childhood cancer survivors are at risk for premature ovarian insufficiency, especially after treatment with alkylating agents. The objective of this report is to highlight a case in which this phenomenon caused a false-positive pregnancy test.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2024-0019_abs_002\">\n                  <jats:title>Case presentation<\/jats:title>\n                  <jats:p>A workup was performed in a 14-year-old girl with a positive pregnancy test. She was diagnosed with stage IV neuroblastoma of the left adrenal gland at the age of\u00a04 years. She received extensive treatment, including alkylating agents, and had been diagnosed with premature ovarian insufficiency. An LH\/hCG suppression test was performed using high dose 17\u202fb\u00e8ta-estradiol: hCG levels normalized.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2024-0019_abs_003\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The pregnancy test was false-positive due to production of low amounts of hCG by the pituitary gland as a result of high LH concentrations following premature ovarian insufficiency. It may be helpful to perform the LH\/hCG suppression test to prove pituitary origin of the hCG overproduction.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2024-0019","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T09:11:41Z","timestamp":1713172301000},"page":"482-485","source":"Crossref","is-referenced-by-count":0,"title":["A 14-year-old girl with premature ovarian insufficiency but with a positive pregnancy test"],"prefix":"10.1515","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7941-932X","authenticated-orcid":false,"given":"Robbert N.H.","family":"Touwslager","sequence":"first","affiliation":[{"name":"Department of Pediatric Endocrinology , Utrecht University Medical Center, Wilhelmina Children\u2019s Hospital , Utrecht , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Michel","family":"Zwaan","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology , Utrecht , The Netherlands"},{"name":"Erasmus Medical Center , Rotterdam , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boudewijn","family":"Bakker","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology , Utrecht University Medical Center, Wilhelmina Children\u2019s Hospital , Utrecht , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eef G.W.M.","family":"Lentjes","sequence":"additional","affiliation":[{"name":"Central Diagnostic Laboratory, Utrecht University Medical Center , Utrecht , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leendert H.J.","family":"Looijenga","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology , Utrecht , The Netherlands"},{"name":"Department of Pathology , 8124 University Medical Center Utrecht, University of Utrecht , Utrecht , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanneke M.","family":"van Santen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology , Utrecht University Medical Center, Wilhelmina Children\u2019s Hospital , Utrecht , The Netherlands"},{"name":"Princess M\u00e1xima Center for Pediatric Oncology , Utrecht , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2024,4,15]]},"reference":[{"key":"2024081908520429676_j_jpem-2024-0019_ref_001","doi-asserted-by":"crossref","unstructured":"Levine, JM, Whitton, JA, Ginsberg, JP, Green, DM, Leisenring, WM, Stovall, M, et al.. 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