{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:28:21Z","timestamp":1717633701274},"reference-count":9,"publisher":"Walter de Gruyter GmbH","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2024-0061_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Fetal and neonatal hyperthyroidism are most commonly seen in patients whose mothers have Graves\u2019 disease. Rarely, it can be caused by non-autoimmune conditions. As these conditions are rare, the workup and treatment is not uniform and can lead to persistent symptoms and long-term negative health effects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2024-0061_abs_002\">\n                  <jats:title>Case presentation<\/jats:title>\n                  <jats:p>This report describes a patient with congenital hyperthyroidism from a toxic adenoma presenting with fetal tachycardia. The patient was initially managed medically after birth, but was eventually treated with thyroidectomy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2024-0061_abs_003\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This case report highlights an additional, important, differential diagnosis for fetal hyperthyroidism when maternal Graves\u2019 disease has been ruled out.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2024-0061","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T07:04:15Z","timestamp":1713769455000},"page":"569-570","source":"Crossref","is-referenced-by-count":0,"title":["Prenatal presentation of a hyperfunctioning thyroid nodule"],"prefix":"10.1515","volume":"37","author":[{"given":"Marinda G.","family":"Scrushy","sequence":"first","affiliation":[{"name":"Department of General Surgery, University of Texas Southwestern Medical Center , Dallas , TX , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology , University of Texas Southwestern Medical Center , Dallas , TX , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ximena","family":"Lopez","sequence":"additional","affiliation":[{"name":"Department of Pathology , University of Texas Southwestern Medical Center , Dallas , TX , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Diesen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Childrens Health Dallas , Dallas , TX , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2024,4,22]]},"reference":[{"key":"2024060508271905278_j_jpem-2024-0061_ref_001","doi-asserted-by":"crossref","unstructured":"Leger, J, Carel, JC. Diagnosis and management of hyperthyroidism from prenatal life to adolescence. Best Pract Res Clin Endocrinol Metabol 2018;32:373\u201386. https:\/\/doi.org\/10.1016\/j.beem.2018.03.014.","DOI":"10.1016\/j.beem.2018.03.014"},{"key":"2024060508271905278_j_jpem-2024-0061_ref_002","doi-asserted-by":"crossref","unstructured":"Namba, H, Ross, JL, Goodman, D, Fagin, JA. Solitary polyclonal autonomous thyroid nodule: a rare cause of childhood hyperthyroidism. J Clin Endocrinol Metab 1991;72:1108\u201312. https:\/\/doi.org\/10.1210\/jcem-72-5-1108.","DOI":"10.1210\/jcem-72-5-1108"},{"key":"2024060508271905278_j_jpem-2024-0061_ref_003","doi-asserted-by":"crossref","unstructured":"Samuels, SL, Namoc, SM, Bauer, AJ. Neonatal thyrotoxicosis. Clin Perinatol 2018;45:31\u201340. https:\/\/doi.org\/10.1016\/j.clp.2017.10.001.","DOI":"10.1016\/j.clp.2017.10.001"},{"key":"2024060508271905278_j_jpem-2024-0061_ref_004","doi-asserted-by":"crossref","unstructured":"Kaplowitz, PB. Neonatal thyroid disease: testing and management. Pediatr Clin N Am 2019;66:343\u201352. https:\/\/doi.org\/10.1016\/j.pcl.2018.12.005.","DOI":"10.1016\/j.pcl.2018.12.005"},{"key":"2024060508271905278_j_jpem-2024-0061_ref_005","unstructured":"Segni, M. Neonatal hyperthyroidism. In: Feingold, KR, Anawalt, B, Boyce, A, Chrousos, G, Dungan, K, Grossman, A, et al.. editors. Endotext. South Dartmouth, MA: MDText.com, Inc; 2000."},{"key":"2024060508271905278_j_jpem-2024-0061_ref_006","doi-asserted-by":"crossref","unstructured":"Polak, M. [Activating mutations of the TSH receptor: a synthesis highlighting certain pediatric aspects]. Arch Pediatr 1998;4:375s\u20139s. https:\/\/doi.org\/10.1016\/s0929-693x(99)80194-8.","DOI":"10.1016\/S0929-693X(99)80194-8"},{"key":"2024060508271905278_j_jpem-2024-0061_ref_007","doi-asserted-by":"crossref","unstructured":"Stocco, E, Pelizzo, MR, Grassetto, G, Pagetta, C, Larizza, D, Massaro, A, et al.. Mini-invasive videoassisted thyroid lobectomy for neonatal hyperfunctioning adenoma related to a somatic TSHr gene mutation. Ann Endocrinol 2012;73:230\u20132. https:\/\/doi.org\/10.1016\/j.ando.2012.03.037.","DOI":"10.1016\/j.ando.2012.03.037"},{"key":"2024060508271905278_j_jpem-2024-0061_ref_008","doi-asserted-by":"crossref","unstructured":"Kopp, P, Muirhead, S, Jourdain, N, Gu, WX, Jameson, JL, Rodd, C. Congenital hyperthyroidism caused by a solitary toxic adenoma harboring a novel somatic mutation (serine281-->isoleucine) in the extracellular domain of the thyrotropin receptor. J Clin Invest 1997;100:1634\u20139. https:\/\/doi.org\/10.1172\/jci119687.","DOI":"10.1172\/JCI119687"},{"key":"2024060508271905278_j_jpem-2024-0061_ref_009","doi-asserted-by":"crossref","unstructured":"Francis, GL, Waguespack, SG, Bauer, AJ, Angelos, P, Benvenga, S, Cerutti, JM, et al.. Management guidelines for children with thyroid nodules and differentiated thyroid cancer. Thyroid 2015;25:716\u201359. https:\/\/doi.org\/10.1089\/thy.2014.0460.","DOI":"10.1089\/thy.2014.0460"}],"container-title":["Journal of Pediatric Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2024-0061\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2024-0061\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T08:31:38Z","timestamp":1717576298000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2024-0061\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,22]]},"references-count":9,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,5,14]]},"published-print":{"date-parts":[[2024,6,25]]}},"alternative-id":["10.1515\/jpem-2024-0061"],"URL":"https:\/\/doi.org\/10.1515\/jpem-2024-0061","relation":{},"ISSN":["0334-018X","2191-0251"],"issn-type":[{"value":"0334-018X","type":"print"},{"value":"2191-0251","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,22]]}}}