{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T05:45:21Z","timestamp":1761198321291,"version":"3.40.5"},"reference-count":20,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2024-0062_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Arginine-stimulated serum copeptin has been proposed as a new method to diagnose arginine vasopressin (AVP) deficiency in children and adolescents. Herein we investigated the secretagogic potential of clonidine or L-Dopa on the copeptin serum levels in children.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2024-0062_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Eight stimulation tests (4 with clonidine and 4 with L-Dopa) were performed in eight children (5 boys and 3 girls) with a median age of 6.5 years-old, evaluated for short stature due to possible growth hormone deficiency. Serum copeptin levels were measured at 30, 60, 90, and 120\u202fmin after administration of clonidine or L-Dopa.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2024-0062_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Copeptin levels in serum did not show any significant change in either test (clonidine or L-Dopa). The values of copeptin levels compared to the baseline value did not deviate more than 5\u202f% in the clonidine arm (p=0.60) or 8\u202f% in the L-Dopa arm (p=0.75) respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2024-0062_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Data do not support the use of L-Dopa or clonidine as stimulants for evaluating AVP relating disorders in clinical pediatric practice.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2024-0062","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T07:20:26Z","timestamp":1710141626000},"page":"441-444","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of copeptin in children after stimulation with clonidine or L-Dopa"],"prefix":"10.1515","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9730-5027","authenticated-orcid":false,"given":"Aristeidis","family":"Giannakopoulos","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Endocrinology, Medical School , 69182 University of Patras , Patras , Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitra","family":"Kritikou","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Endocrinology, Medical School , 69182 University of Patras , Patras , Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dionisios","family":"Chrysis","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Endocrinology, Medical School , 69182 University of Patras , Patras , Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2024,3,12]]},"reference":[{"key":"2024081908520421861_j_jpem-2024-0062_ref_001","doi-asserted-by":"crossref","unstructured":"Refardt, J, Winzeler, B, Christ-Crain, M. Diabetes insipidus an update. Metab Clin 2020;49:517\u201331.","DOI":"10.1016\/j.ecl.2020.05.012"},{"key":"2024081908520421861_j_jpem-2024-0062_ref_002","doi-asserted-by":"crossref","unstructured":"Dabrowski, E, Kadakia, R, Zimmerman, D. Diabetes insipidus in infants and children. Best practice & research. Clin Endocrinol Metab 2016;30:317\u201328. https:\/\/doi.org\/10.1016\/j.beem.2016.02.006.","DOI":"10.1016\/j.beem.2016.02.006"},{"key":"2024081908520421861_j_jpem-2024-0062_ref_003","doi-asserted-by":"crossref","unstructured":"Cadnapaphornchai, MA, Summer, SN, Falk, S, Thurman, JM, Knepper, MA, Schrier, RW. Effect of primary polydipsia on aquaporin and sodium transporter abundance. Am J Physiol 2003;285:F965\u201371.","DOI":"10.1152\/ajprenal.00085.2003"},{"key":"2024081908520421861_j_jpem-2024-0062_ref_004","doi-asserted-by":"crossref","unstructured":"Kluge, M, Riedl, S, Erhart-Hofmann, B, Hartmann, J, Waldhauser, F. 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