{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:49:22Z","timestamp":1747198162100,"version":"3.40.5"},"reference-count":8,"publisher":"Walter de Gruyter GmbH","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2024-0115_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>GH-releasing peptide-2 (GHRP2) can be used for provocative growth hormone testing (GHT). Since it acts as a powerful stimulus for GH secretion, cut-off peak GH level in GHRP2 loading test (GHRP2T) is higher than in other GHT. Nevertheless, data on response at adolescents are limited. This report aimed to investigate peak GH levels in GHRP2T in adolescents.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2024-0115_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Clinical data of adolescents after onset of puberty who underwent GHRP2T at our institution from May 2010 to March 2023 were collected retrospectively. Subjects were classified into three groups according to underlying diseases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2024-0115_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 23 patients were included: 12 in organic or genetic GHD (o\/gGHD) group, three in idiopathic GHD (iGHD) group, and eight in short stature (SS) group. The median GH peak levels were 3.4\u202fng\/mL in o\/gGHD group, 88.9\u202fng\/mL in iGHD group, and 90.1\u202fng\/mL in SS group, indicating a robust response of GH peak levels in iGHD and SS groups. Two patients exceeded the cut-off for GHRP2T but below for other GHT, indicating the current cut-off for GHRP2T may miss some GHD patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2024-0115_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The GH response to GHRP2T in adolescents except the o\/gGHD group may be robustly responsive. For the correct diagnosis of GHD, the cut-off peak GH levels in GHRP2T in adolescents may require revisiting.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2024-0115","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T11:40:34Z","timestamp":1720006834000},"page":"730-733","source":"Crossref","is-referenced-by-count":0,"title":["Robust growth hormone responses to GH-releasing peptide 2 in adolescents"],"prefix":"10.1515","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7798-2100","authenticated-orcid":false,"given":"Takanori","family":"Onuki","sequence":"first","affiliation":[{"name":"Division of Pediatrics, Department of Homeostatic Regulation and Development, Niigata University Graduate School of Medical and Dental Sciences , Niigata , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadokoro","family":"Hiroaki","sequence":"additional","affiliation":[{"name":"Division of Pediatrics, Department of Homeostatic Regulation and Development, Niigata University Graduate School of Medical and Dental Sciences , Niigata , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Sawano","sequence":"additional","affiliation":[{"name":"Division of Pediatrics, Department of Homeostatic Regulation and Development, Niigata University Graduate School of Medical and Dental Sciences , Niigata , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nao","family":"Shibata","sequence":"additional","affiliation":[{"name":"Division of Pediatrics, Department of Homeostatic Regulation and Development, Niigata University Graduate School of Medical and Dental Sciences , Niigata , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi","family":"Nyuzuki","sequence":"additional","affiliation":[{"name":"Division of Pediatrics, Department of Homeostatic Regulation and Development, Niigata University Graduate School of Medical and Dental Sciences , Niigata , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Division of Pediatrics, Department of Homeostatic Regulation and Development, Niigata University Graduate School of Medical and Dental Sciences , Niigata , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayasu","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery , Brain Research Institute, Niigata University , Niigata , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirohito","family":"Sone","sequence":"additional","affiliation":[{"name":"Department of Hematology , Endocrinology and Metabolism, Niigata University Faculty of Medicine , Niigata , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5882-661X","authenticated-orcid":false,"given":"Keisuke","family":"Nagasaki","sequence":"additional","affiliation":[{"name":"Division of Pediatrics, Department of Homeostatic Regulation and Development, Niigata University Graduate School of Medical and Dental Sciences , Niigata , Japan"},{"name":"Life Science Research Center, Nagano Children\u2019s Hospital, 3100 Toyoshina , Azumino 399-8288 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2024,7,4]]},"reference":[{"key":"2024081211232797699_j_jpem-2024-0115_ref_001","doi-asserted-by":"crossref","unstructured":"Carroll, PV, Christ, ER, Bengtsson, BA, Carlsson, L, Christiansen, JS. Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review. Growth Hormone Research Society Scientific Committee. J Clin Endocrinol Metab 1998;83:382\u201395. https:\/\/doi.org\/10.1210\/jc.83.2.382.","DOI":"10.1210\/jc.83.2.382"},{"key":"2024081211232797699_j_jpem-2024-0115_ref_002","doi-asserted-by":"crossref","unstructured":"Chinoy, A, Murray, PG. Diagnosis of growth hormone deficiency in the paediatric and transitional age. Best Pract Res Clin Endocrinol Metabol 2016;30:737\u201347. https:\/\/doi.org\/10.1016\/j.beem.2016.11.002.","DOI":"10.1016\/j.beem.2016.11.002"},{"key":"2024081211232797699_j_jpem-2024-0115_ref_003","doi-asserted-by":"crossref","unstructured":"Asakura, Y, Toyota, Y, Muroya, K, Adachi, M. Growth hormone response to GH-releasing peptide-2 in children. J Pediatr Endocrinol Metab 2010;23:473\u201380. https:\/\/doi.org\/10.1515\/jpem.2010.078.","DOI":"10.1515\/jpem.2010.078"},{"key":"2024081211232797699_j_jpem-2024-0115_ref_004","doi-asserted-by":"crossref","unstructured":"Fukuda, I, Hizuka, N, Muraoka, T, Ichihara, A. Adult growth hormone deficiency: current concepts. Neurol Med Chir (Tokyo) 2014;54:599\u2013605. https:\/\/doi.org\/10.2176\/nmc.ra.2014-0088.","DOI":"10.2176\/nmc.ra.2014-0088"},{"key":"2024081211232797699_j_jpem-2024-0115_ref_005","unstructured":"Guidelines for the diagnosis and treatment of growth hormone deficient short stature and guidelines for the diagnosis and treatment of adult growth hormone deficiency [Internet]. Research Study Group on the Hypothalamo Pituitary Dysfunction, the Ministry of Health, Labor and Welfare. 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Short-term estradiol supplementation augments growth hormone (GH) secretory responsiveness to dose-varying GH-releasing peptide infusions in healthy postmenopausal women. J Clin Endocrinol Metab 2001;86:551\u201360. https:\/\/doi.org\/10.1210\/jc.86.2.551.","DOI":"10.1210\/jc.86.2.551"}],"container-title":["Journal of Pediatric Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2024-0115\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2024-0115\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T11:24:46Z","timestamp":1723461886000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2024-0115\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,4]]},"references-count":8,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2024,7,16]]},"published-print":{"date-parts":[[2024,8,27]]}},"alternative-id":["10.1515\/jpem-2024-0115"],"URL":"https:\/\/doi.org\/10.1515\/jpem-2024-0115","relation":{},"ISSN":["0334-018X","2191-0251"],"issn-type":[{"type":"print","value":"0334-018X"},{"type":"electronic","value":"2191-0251"}],"subject":[],"published":{"date-parts":[[2024,7,4]]}}}