{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T03:25:49Z","timestamp":1785209149512,"version":"3.55.0"},"reference-count":15,"publisher":"Walter de Gruyter GmbH","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2024-0194_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Congenital adrenal hyperplasia (CAH) is an uncommon genetic disorder which affects cortisol production in the adrenal glands. It is usually treated with glucocorticoids. We present a case of non-classical CAH caused by the partial deficiency of 11 beta-hydroxylase (11\u03b2OH) which was treated with aldosterone antagonist (eplerenone) monotherapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2024-0194_abs_002\">\n                  <jats:title>Case presentation<\/jats:title>\n                  <jats:p>An adolescent male was diagnosed with 11 beta-hydroxylase deficiency (11\u03b2OHD) at 13 years of age when he presented with hypertension, fatigue and headaches. He was initially treated with glucocorticoids, but requested an alternative therapy. Eplerenone was commenced at 25\u202fmg with subsequent dose increases to 100\u202fmg daily. His hypertension was controlled on this regimen, achieving a 24\u202fh average blood pressure of 124\/81\u202fmmHg.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2024-0194_abs_003\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>CAH caused by 11\u03b2OHD is a known cause of hypertension. It is usually managed with glucocorticoids, and antihypertensives are added if blood pressure remains uncontrolled. In this case, glucocorticoid therapy was not tolerated and treatment with aldosterone antagonist monotherapy was effective in controlling his hypertension.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2024-0194","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T05:20:33Z","timestamp":1726723233000},"page":"1100-1103","source":"Crossref","is-referenced-by-count":1,"title":["Mineralocorticoid receptor antagonist monotherapy in pediatric non-classical 11\u03b2-hydroxylase deficiency"],"prefix":"10.1515","volume":"37","author":[{"given":"Elaine C.","family":"Kennedy","sequence":"first","affiliation":[{"name":"INFANT Research Centre , University College Cork , Cork , Ireland"},{"name":"Department of Paediatrics and Child Health , Cork University Hospital , Cork , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Stack","sequence":"additional","affiliation":[{"name":"Department of Nephrology , Children\u2019s Health Ireland at Temple Street , Dublin , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eirin","family":"Carolan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology , Children\u2019s Health Ireland at Temple Street , Dublin , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maeve","family":"Durkan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology , Bon Secours Hospital , Cork , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7231-8331","authenticated-orcid":false,"given":"Caroline M.","family":"Joyce","sequence":"additional","affiliation":[{"name":"INFANT Research Centre , University College Cork , Cork , Ireland"},{"name":"Department of Biochemistry , Cork University Hospital , Cork , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin P.","family":"Hawkes","sequence":"additional","affiliation":[{"name":"INFANT Research Centre , University College Cork , Cork , Ireland"},{"name":"Department of Paediatrics and Child Health , Cork University Hospital , Cork , Ireland"},{"name":"Perelman School of Medicine , University of Pennsylvania , Philadelphia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2024,9,20]]},"reference":[{"key":"2024120211230930675_j_jpem-2024-0194_ref_001","doi-asserted-by":"crossref","unstructured":"Khattab, A, Haider, S, Kumar, A, Dhawan, S, Alam, D, Romero, R, et al.. Clinical, genetic, and structural basis of congenital adrenal hyperplasia due to 11\u03b2-hydroxylase deficiency. Proc Natl Acad Sci USA 2017;114:E1933\u2013e40. https:\/\/doi.org\/10.1073\/pnas.1621082114.","DOI":"10.1073\/pnas.1621082114"},{"key":"2024120211230930675_j_jpem-2024-0194_ref_002","doi-asserted-by":"crossref","unstructured":"Bulsari, K, Falhammar, H. Clinical perspectives in congenital adrenal hyperplasia due to 11\u03b2-hydroxylase deficiency. Endocrine 2017;55:19\u201336. https:\/\/doi.org\/10.1007\/s12020-016-1189-x.","DOI":"10.1007\/s12020-016-1189-x"},{"key":"2024120211230930675_j_jpem-2024-0194_ref_003","doi-asserted-by":"crossref","unstructured":"Mooij, CF, Parajes, S, Rose, IT, Taylor, AE, Bayraktaroglu, T, Wass, JA, et al.. Characterization of the molecular genetic pathology in patients with 11\u03b2-hydroxylase deficiency. 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