{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:49:25Z","timestamp":1747198165474,"version":"3.40.5"},"reference-count":12,"publisher":"Walter de Gruyter GmbH","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2024-0258_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>This case report delves into the intricate management of a newborn with transient neonatal diabetes mellitus (TNDM), shedding light on the complexities and challenges in treatment decisions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2024-0258_abs_002\">\n                  <jats:title>Case presentation<\/jats:title>\n                  <jats:p>Born prematurely with a low birth weight and a maternal background of gestational diabetes, the infant developed hyperglycaemia necessitating intravenous insulin therapy. Subsequent genetic testing confirmed 6q24-TNDM, due to the uniparental disomy of the whole of chromosome 6. Glibenclamide, a second-generation sulfonylurea, was cautiously introduced but discontinued due to adverse effects. Despite post-meal hyperglycaemia, blood glucose levels stabilised over subsequent weeks. Regular follow-ups demonstrated appropriate growth and development and the resolution of diabetes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2024-0258_abs_003\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This unique case highlights the need for multidisciplinary collaboration, tailored treatment strategies, and vigilant monitoring in managing 6q24-TNDM.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2024-0258","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T07:34:02Z","timestamp":1726472042000},"page":"995-998","source":"Crossref","is-referenced-by-count":0,"title":["The complexities of managing a newborn with 6q24 transient neonatal diabetes mellitus: a case report"],"prefix":"10.1515","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6903-7803","authenticated-orcid":false,"given":"Yannick","family":"De Silva","sequence":"first","affiliation":[{"name":"Central Coast Clinical School , 5982 The University of Newcastle , Gosford , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stewart","family":"Birt","sequence":"additional","affiliation":[{"name":"Central Coast Specialist Centre , Gosford Hospital , Gosford , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2024,9,17]]},"reference":[{"key":"2024111114160027670_j_jpem-2024-0258_ref_001","doi-asserted-by":"crossref","unstructured":"Hussain, A, Ali, I, Khan, AU, Khan, TM. Glibenclamide-induced profound hypoglycaemic crisis: a case report. Ther Adv Endocrinol Metab 2016;7:84\u20137. https:\/\/doi.org\/10.1177\/2042018816632440.","DOI":"10.1177\/2042018816632440"},{"key":"2024111114160027670_j_jpem-2024-0258_ref_002","unstructured":"Rogers, M, Sands, C, Self, T. Sulfonylurea-induced hypoglycemia: the case against glyburide. Consultant 2011;51."},{"key":"2024111114160027670_j_jpem-2024-0258_ref_003","unstructured":"Amglidia (glibenclamide) for the treatment of neonatal diabetes. 2019 [cited 2023 May 29]. Available from: https:\/\/www.clinicaltrialsarena.com\/projects\/amglidia-glibenclamide\/."},{"key":"2024111114160027670_j_jpem-2024-0258_ref_004","doi-asserted-by":"crossref","unstructured":"Temple, IK, Shield, JP. Transient neonatal diabetes, a disorder of imprinting. J Med Genet 2002;39:872\u20135. https:\/\/doi.org\/10.1136\/jmg.39.12.872.","DOI":"10.1136\/jmg.39.12.872"},{"key":"2024111114160027670_j_jpem-2024-0258_ref_005","doi-asserted-by":"crossref","unstructured":"Hermann, R, Laine, AP, Johansson, C, Niederland, T, Tokarska, L, Dziatkowiak, H, et al.. Transient but not permanent neonatal diabetes mellitus is associated with paternal uniparental isodisomy of chromosome 6. Pediatrics 2000;105(1 Pt 1):49\u201352. https:\/\/doi.org\/10.1542\/peds.105.1.49.","DOI":"10.1542\/peds.105.1.49"},{"key":"2024111114160027670_j_jpem-2024-0258_ref_006","doi-asserted-by":"crossref","unstructured":"Beltrand, J, Busiah, K, Vaivre-Douret, L, Fauret, AL, Berdugo, M, Cave, H, et al.. Neonatal diabetes mellitus. Front Pediatr 2020;8:540718. https:\/\/doi.org\/10.3389\/fped.2020.540718.","DOI":"10.3389\/fped.2020.540718"},{"key":"2024111114160027670_j_jpem-2024-0258_ref_007","unstructured":"Temple, IK, Mackay, DJG. Diabetes mellitus, 6q24-related transient neonatal. In: Adam, MP, Mirzaa, GM, Pagon, RA, Wallace, SE, Bean, LJH, Gripp, KW, editors, et al.. GeneReviews((R)). Seattle (WA): University of Washington; 1993."},{"key":"2024111114160027670_j_jpem-2024-0258_ref_008","unstructured":"Transient neonatal diabetes mellitus. 2014 [cited 2023 May 29]. Available from: https:\/\/www.orpha.net\/consor\/cgi-bin\/OC_Exp.php?lng=EN&Expert=99886."},{"key":"2024111114160027670_j_jpem-2024-0258_ref_009","doi-asserted-by":"crossref","unstructured":"Babiker, T, Vedovato, N, Patel, K, Thomas, N, Finn, R, Mannikko, R, et al.. Successful transfer to sulfonylureas in KCNJ11 neonatal diabetes is determined by the mutation and duration of diabetes. Diabetologia 2016;59:1162\u20136. https:\/\/doi.org\/10.1007\/s00125-016-3921-8.","DOI":"10.1007\/s00125-016-3921-8"},{"key":"2024111114160027670_j_jpem-2024-0258_ref_010","doi-asserted-by":"crossref","unstructured":"Carmody, D, Bell, CD, Hwang, JL, Dickens, JT, Sima, DI, Felipe, DL, et al.. Sulfonylurea treatment before genetic testing in neonatal diabetes: pros and cons. J Clin Endocrinol Metab 2014;99:E2709\u201314. https:\/\/doi.org\/10.1210\/jc.2014-2494.","DOI":"10.1210\/jc.2014-2494"},{"key":"2024111114160027670_j_jpem-2024-0258_ref_011","doi-asserted-by":"crossref","unstructured":"Thurber, BW, Carmody, D, Tadie, EC, Pastore, AN, Dickens, JT, Wroblewski, KE, et al.. Age at the time of sulfonylurea initiation influences treatment outcomes in KCNJ11-related neonatal diabetes. Diabetologia 2015;58:1430\u20135. https:\/\/doi.org\/10.1007\/s00125-015-3593-9.","DOI":"10.1007\/s00125-015-3593-9"},{"key":"2024111114160027670_j_jpem-2024-0258_ref_012","doi-asserted-by":"crossref","unstructured":"Flanagan, SE, Mackay, DJ, Greeley, SA, McDonald, TJ, Mericq, V, Hassing, J, et al.. Hypoglycaemia following diabetes remission in patients with 6q24 methylation defects: expanding the clinical phenotype. Diabetologia 2013;56:218\u201321. https:\/\/doi.org\/10.1007\/s00125-012-2766-z.","DOI":"10.1007\/s00125-012-2766-z"}],"container-title":["Journal of Pediatric Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2024-0258\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2024-0258\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T14:16:23Z","timestamp":1731334583000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2024-0258\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,17]]},"references-count":12,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,9,20]]},"published-print":{"date-parts":[[2024,11,26]]}},"alternative-id":["10.1515\/jpem-2024-0258"],"URL":"https:\/\/doi.org\/10.1515\/jpem-2024-0258","relation":{},"ISSN":["0334-018X","2191-0251"],"issn-type":[{"type":"print","value":"0334-018X"},{"type":"electronic","value":"2191-0251"}],"subject":[],"published":{"date-parts":[[2024,9,17]]}}}