{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T09:56:39Z","timestamp":1738749399222,"version":"3.37.0"},"reference-count":47,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T00:00:00Z","timestamp":1734998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2024-0314_abs_002\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Exocrine pancreatic insufficiency has been demonstrated in type 1 diabetes (T1D); lower concentrations of pancreatic enzymes have been associated with metabolic risk (MR). Influence of puberty and MR factors on serum concentrations of amylase and lipase remain unexplored in Indian youth with T1D. 1) To characterize and predict determinants of serum amylase and lipase concentrations in adolescents\/youth with T1D. 2) To assess relationship between amylase, lipase, and prevalence of MR.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2024-0314_abs_003\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Cross sectional, observational study on 291 (155 girls) adolescents\/youth (10\u201324 years) with T1D. History, examination, body composition, biochemistry (glycated hemoglobin [HbA1c], thyroid stimulating hormone [TSH], lipids).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2024-0314_abs_005\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Mean age, diabetes duration and HbA1c were 15.3, 7.0 years and 10.0\u00a0\u00b1\u00a02.1, respectively. Relative risk of lower amylase\/higher lipase concentrations (&lt;median) in participants with poor glycemic control (HbA1c&gt;9.5\u202f%) was 1.42 and 1.34, respectively, though these did not reach statistical significance. In pubertal participants, amylase was lower and lipase higher; association was not found with MR. Higher TSH and lower serum calcium were significantly associated with higher lipase (p&lt;0.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2024-0314_abs_006\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We have characterized amylase and lipase concentrations across puberty; poor glycemic control tended to be associated with lower amylase and higher lipase, though these findings did not reach statistical significance. Amylase and lipase concentrations should be monitored in Indian adolescents with T1D, particularly in those with poor metabolic control, puberty, uncontrolled hypothyroidism, or reduced calcium intake, while further longitudinal and larger studies are needed to generalize these findings.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2024-0314","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T04:50:37Z","timestamp":1734929437000},"page":"146-154","source":"Crossref","is-referenced-by-count":0,"title":["Patterns and determinants of serum amylase, lipase concentrations in Indian adolescents and youth with type 1 diabetes"],"prefix":"10.1515","volume":"38","author":[{"given":"Nimisha Shankar","family":"Dange","sequence":"first","affiliation":[{"name":"Department of Growth and Pediatric Endocrinology , Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital , Pune , Maharashtra , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chirantap","family":"Oza","sequence":"additional","affiliation":[{"name":"Department of Growth and Pediatric Endocrinology , Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital , Pune , Maharashtra , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vaman","family":"Khadilkar","sequence":"additional","affiliation":[{"name":"Department of Growth and Pediatric Endocrinology , Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital , Pune , Maharashtra , India"},{"name":"Interdisciplinary School of Health Sciences , Savitribai Phule University , Pune , Maharahstra , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ketan","family":"Gondhalekar","sequence":"additional","affiliation":[{"name":"Department of Growth and Pediatric Endocrinology , Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital , Pune , Maharashtra , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sushil","family":"Yewale","sequence":"additional","affiliation":[{"name":"Department of Growth and Pediatric Endocrinology , Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital , Pune , Maharashtra , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anuradha","family":"Khadilkar","sequence":"additional","affiliation":[{"name":"Department of Growth and Pediatric Endocrinology , Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital , Pune , Maharashtra , India"},{"name":"Interdisciplinary School of Health Sciences , Savitribai Phule University , Pune , Maharahstra , India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2024,12,24]]},"reference":[{"key":"2025020411462962789_j_jpem-2024-0314_ref_001","doi-asserted-by":"crossref","unstructured":"Barreto, SG, Carati, CJ, Toouli, J, Saccone, GTP. 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