{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:10:47Z","timestamp":1791835847540,"version":"4.3.4"},"reference-count":39,"publisher":"Walter de Gruyter GmbH","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jpem-2024-0323_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the role of Cardiotrophin-1 (CT-1) and echocardiography in early detection of subclinical Diabetic Cardiomyopathy (DCM) in children with type 1 Diabetes Mellitus (T1D).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2024-0323_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This case-control study included two groups of children and adolescents aged between 7 and 18. Group (1) included forty patients with T1D (duration &gt; 5 years) regularly followed at the children's hospital of Cairo University, and Group (2) included forty age and sex-matched healthy subjects as a control group. The serum level of CT-1 was measured, and conventional echocardiography, tissue Doppler imaging (TDI), and 2D speckle tracking echocardiography were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2024-0323_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The level of CT-1 in the cases ranged from 11 to 1039.4 pg\/ml with a median (IQR) of 19.4 (16.60\u201325.7) pg\/ml, while its level in the control group ranged from 10.8 to 162.6 pg\/ml with a median (IQR) of 20.2 (16.2\u201324.8) pg\/ml. CT-1 levels showed no statistically significant difference between cases and controls. Patients had significantly higher mean left ventricle E\/E\u2032 ratio (p&lt;0.001), lower mean 2D global longitudinal strain (GLS) of the left ventricle (LV) (p&lt;0.001), and lower mean GLS of the right ventricle (RV) (p&lt;0.001) compared to controls. Ofpatients with diabetes, 75 % had LV diastolic dysfunction, 85 % had RV diastolic dysfunction, 97.5 % had LV systolic dysfunction, and 100 % had RV systolic dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2024-0323_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Non-conventional echocardiography is important for early perception of subclinical DCM in patients with T1D. CT-1 was not specific for early detection of DCM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jpem-2024-0323","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T23:40:40Z","timestamp":1725320440000},"page":"875-884","source":"Crossref","is-referenced-by-count":4,"title":["The role of Cardiotrophin-1 and echocardiography in early detection of subclinical diabetic cardiomyopathy in children and adolescents with type 1 diabetes mellitus"],"prefix":"10.1515","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9745-6770","authenticated-orcid":false,"given":"Samah A.","family":"Hassanein","sequence":"first","affiliation":[{"name":"Pediatric Endocrinology, Diabetes, Endocrinology and Metabolism Pediatric Unit (DEMPU), Department of Pediatrics, Faculty of Medicine , Cairo University , Cairo , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2198-8228","authenticated-orcid":false,"given":"Mona M.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, Diabetes, Endocrinology and Metabolism Pediatric Unit (DEMPU), Department of Pediatrics, Faculty of Medicine , Cairo University , Cairo , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4245-7482","authenticated-orcid":false,"given":"Mohamed","family":"Samir","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology, Department of Pediatrics, Faculty of Medicine , Cairo University , Cairo , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8057-1070","authenticated-orcid":false,"given":"Mahmoud O.","family":"Aboudeif","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology, Department of Pediatrics, Faculty of Medicine , Cairo University , Cairo , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5396-838X","authenticated-orcid":false,"given":"Mohamed S.","family":"Thabet","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Cairo University , Cairo , Egypt"},{"name":"Department of Pediatrics , Imbaba General Hospital , Cairo , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4767-3256","authenticated-orcid":false,"given":"Mona","family":"Abdullatif","sequence":"additional","affiliation":[{"name":"Clinical and Chemical Pathology Department, Faculty of Medicine , Cairo University , Cairo , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2112-8930","authenticated-orcid":false,"given":"Dina","family":"Khedr","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, Diabetes, Endocrinology and Metabolism Pediatric Unit (DEMPU), Department of Pediatrics, Faculty of Medicine , Cairo University , Cairo , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2024,9,3]]},"reference":[{"key":"2026051215020582562_j_jpem-2024-0323_ref_001","doi-asserted-by":"crossref","unstructured":"Benjamin, EJ, Virani, SS, Callaway, CW, Chamberlain, AM, Chang, AR, Cheng, S, et al.. 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