{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T08:56:59Z","timestamp":1736585819305,"version":"3.32.0"},"reference-count":12,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2024-0380_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Growth failure can result from various underlying causes, necessitating a thorough evaluation. Reninoma, a rare renin-secreting tumor, is an uncommon cause of hypertension, especially in paediatric patients, and has not been associated with growth failure until now.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2024-0380_abs_002\">\n                  <jats:title>Case presentation<\/jats:title>\n                  <jats:p>An 11-year-old girl presented with complaints of poor height gain, headaches, increased thirst, and vomiting. The evaluation revealed severe hypertension and hypokalemic alkalosis. Investigations indicated renin-dependent hypertension, and imaging identified a right renal mass. Renal venous sampling confirmed renin production from the tumor. A right open partial nephrectomy was performed, resulting in the normalization of blood pressure and improved growth. Over the following years, she achieved a significant catch-up growth, regaining her original height percentile and the target adult height.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2024-0380_abs_003\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This case adds to the limited literature on paediatric reninoma. It highlights a rare presentation of reninoma causing hypertension and growth failure in a child. The growth failure was likely due to hypokalemic alkalosis-induced low insulin-like growth factor 1 (IGF-1) levels, a mechanism not previously documented in paediatric reninoma cases. Surgical excision of the tumor led to normalization of blood pressure and metabolic alkalosis with significant growth recovery.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2024-0380","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T19:25:15Z","timestamp":1733945115000},"page":"73-78","source":"Crossref","is-referenced-by-count":0,"title":["Reninoma: an unusual cause of growth failure"],"prefix":"10.1515","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9540-1613","authenticated-orcid":false,"given":"Nupoor","family":"Vaghasia","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Diabetes , Max Super Speciality Hospital , Saket , Delhi , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganesh","family":"Jevalikar","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes , Max Super Speciality Hospital , Saket , Delhi , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Shafi","family":"Kuchay","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes , Medanta The Medicity Hospital , Gurgaon , Delhi (NCR) , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lipika","family":"Lipi","sequence":"additional","affiliation":[{"name":"Department of Pathology , Medanta The Medicity , Gurgaon , Delhi (NCR) , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ambrish","family":"Mithal","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes , Max Super Speciality Hospital , Saket , Delhi , India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2024,12,12]]},"reference":[{"key":"2025011004321629704_j_jpem-2024-0380_ref_001","doi-asserted-by":"crossref","unstructured":"Bell, CS, Samuel, JP, Samuels, JA. Prevalence of hypertension in children. Hypertension 2019;73:148\u201352. https:\/\/doi.org\/10.1161\/hypertensionaha.118.11673.","DOI":"10.1161\/HYPERTENSIONAHA.118.11673"},{"key":"2025011004321629704_j_jpem-2024-0380_ref_002","doi-asserted-by":"crossref","unstructured":"Thomas, J, Stonebrook, E, Kallash, M. Pediatric hypertension: review of the definition, diagnosis, and initial management. Int J Pediatr Adolesc Med 2022;9:1\u20136. https:\/\/doi.org\/10.1016\/j.ijpam.2020.09.005.","DOI":"10.1016\/j.ijpam.2020.09.005"},{"key":"2025011004321629704_j_jpem-2024-0380_ref_003","doi-asserted-by":"crossref","unstructured":"Hayes, AG, Stowasser, M, Umapathysivam, MM, Falhammar, H, Torpy, DJ. Approach to the patient: reninoma. J Clin Endocrinol Metabolism 2024;109:e809\u201316. https:\/\/doi.org\/10.1210\/clinem\/dgad516.","DOI":"10.1210\/clinem\/dgad516"},{"key":"2025011004321629704_j_jpem-2024-0380_ref_004","doi-asserted-by":"crossref","unstructured":"Wolley, M, Gordon, RD, Stowasser, M. Reninoma: the importance of renal vein renin ratios for lateralisation and diagnosis. Am J Nephrol 2014;39:16\u20139. https:\/\/doi.org\/10.1159\/000357410.","DOI":"10.1159\/000357410"},{"key":"2025011004321629704_j_jpem-2024-0380_ref_005","doi-asserted-by":"crossref","unstructured":"Nugent, JT, Young, C, Funaro, MC, Jiang, K, Saran, I, Ghazi, L, et al.. Prevalence of secondary hypertension in otherwise healthy youths with a new diagnosis of hypertension: a meta-analysis. J Pediatr 2022;244:30\u20137.e10. https:\/\/doi.org\/10.1016\/j.jpeds.2022.01.047.","DOI":"10.1016\/j.jpeds.2022.01.047"},{"key":"2025011004321629704_j_jpem-2024-0380_ref_006","doi-asserted-by":"crossref","unstructured":"Flynn, JT, Kaelber, DC, Baker-Smith, CM, Blowey, D, Carroll, AE, Daniels, SR, et al.. Clinical practice guideline for screening and management of high blood pressure in children and adolescents. 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Growth failure in children with metabolic alkalosis and with metabolic acidosis. Nephron 1987;45:182\u20135. https:\/\/doi.org\/10.1159\/000184113.","DOI":"10.1159\/000184113"},{"key":"2025011004321629704_j_jpem-2024-0380_ref_010","doi-asserted-by":"crossref","unstructured":"Flyvbjerg, A, D\u00f8rup, I, Everts, ME, Orskov, H. Evidence that potassium deficiency induces growth retardation through reduced circulating levels of growth hormone and insulin-like growth factor I. Metabolism 1991;40:769\u201375. https:\/\/doi.org\/10.1016\/0026-0495(91)90001-d.","DOI":"10.1016\/0026-0495(91)90001-D"},{"key":"2025011004321629704_j_jpem-2024-0380_ref_011","doi-asserted-by":"crossref","unstructured":"Simopoulos, AP. Growth characteristics in patients with Bartter\u2019s syndrome. 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