{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T11:18:32Z","timestamp":1781349512246,"version":"3.54.1"},"reference-count":33,"publisher":"Walter de Gruyter GmbH","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2024-0412_abs_001\">\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Juvenile idiopathic arthritis (JIA) is a chronic inflammatory disease beginning before 16 years. Inflammatory cytokine, medication, and genetic factors may lead to puberty disorders in children with JIA. The main objectives of this systematic review were to elucidate the impact of JIA on puberty and identify the influential factors that disrupt puberty.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2024-0412_abs_002\">\n                  <jats:title>Content<\/jats:title>\n                  <jats:p>A systematic literature review was performed on pubertal disorders from Medline, Google Scholar, and Scopus databases. This systematic review followed the preferred reporting items for systematic review guidelines. The initial search yielded 4,011 articles: identified by Google Scholar (3,880), PubMed (99), and Scopus (940). Finally, 11 articles were retained.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2024-0412_abs_003\">\n                  <jats:title>Summary and Outlook<\/jats:title>\n                  <jats:p>The age of menarche onset, Tanner stage, and pubertal signs were later compared with controls. The mean age of menarche onset ranged from 12.0\u00a0\u00b1\u00a00.3 to 13.39\u00a0\u00b1\u00a00.93 years for the JIA girls. This delay was more reported in the polyarticular and oligoarticular subtypes. Menstrual irregularities, metrorrhagia with irregular cycles, primary oligomenorrhea, and secondary amenorrhea were also reported. Factors found to influence delayed menarche and puberty were steroid use, JIA subtype, disease duration, and age at onset. Any studies have focused on the effect of puberty on JIA outcomes. Overall, our review revealed that pubertal disorders are frequent in JIA patients with polyarticular and systemic subtypes. However, some influencing factors remain editable if well-assessed and controlled.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2024-0412","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T09:42:45Z","timestamp":1743154965000},"page":"551-561","source":"Crossref","is-referenced-by-count":1,"title":["Pubertal disorders in juvenile idiopathic arthritis: a systemic review"],"prefix":"10.1515","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9185-1710","authenticated-orcid":false,"given":"Soumaya","family":"Boussaid","sequence":"first","affiliation":[{"name":"Rheumatology Department , Rabta Hospital , Tunis , Tunisia"},{"name":"Faculty of Medicine of Tunis , University Tunis El Manar , Tunis , Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Rekik","sequence":"additional","affiliation":[{"name":"Rheumatology Department , Rabta Hospital , Tunis , Tunisia"},{"name":"Faculty of Medicine of Tunis , University Tunis El Manar , Tunis , Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanene Lassoued","family":"Ferjani","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of Tunis , University Tunis El Manar , Tunis , Tunisia"},{"name":"Rheumatology Department (adult and pediatric) , Kassab Institute of Orthopedics , Tunis , Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maissa","family":"Abbes","sequence":"additional","affiliation":[{"name":"Rheumatology Department , Rabta Hospital , Tunis , Tunisia"},{"name":"Faculty of Medicine of Tunis , University Tunis El Manar , Tunis , Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safa","family":"Rahmouni","sequence":"additional","affiliation":[{"name":"Rheumatology Department , Rabta Hospital , Tunis , Tunisia"},{"name":"Faculty of Medicine of Tunis , University Tunis El Manar , Tunis , Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaoula","family":"Zouaoui","sequence":"additional","affiliation":[{"name":"Rheumatology Department , Rabta Hospital , Tunis , Tunisia"},{"name":"Faculty of Medicine of Tunis , University Tunis El Manar , Tunis , Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rim","family":"Dhahri","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of Tunis , University Tunis El Manar , Tunis , Tunisia"},{"name":"Rheumatology Department of Military Hospital of Tunis , Tunis , Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wafa","family":"Hamdi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of Tunis , University Tunis El Manar , Tunis , Tunisia"},{"name":"Rheumatology Department (adult and pediatric) , Kassab Institute of Orthopedics , Tunis , Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hela","family":"Sahli","sequence":"additional","affiliation":[{"name":"Rheumatology Department , Rabta Hospital , Tunis , Tunisia"},{"name":"Faculty of Medicine of Tunis , University Tunis El Manar , Tunis , Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"key":"2025053006390461756_j_jpem-2024-0412_ref_001","unstructured":"Petty, RE, Southwood, TR, Manners, P, Baum, J, Glass, DN, Goldenberg, J, et al.. International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J Rheumatol 2004;31:390\u20132."},{"key":"2025053006390461756_j_jpem-2024-0412_ref_002","doi-asserted-by":"crossref","unstructured":"Bechtold, S, Simon, D. Growth abnormalities in children and adolescents with juvenile idiopathic arthritis. Rheumatol Int 2014;34:1483\u20138. https:\/\/doi.org\/10.1007\/s00296-014-3022-2.","DOI":"10.1007\/s00296-014-3022-2"},{"key":"2025053006390461756_j_jpem-2024-0412_ref_003","doi-asserted-by":"crossref","unstructured":"Lui, JC, Nilsson, O, Baron, J. Growth plate senescence and catch-up growth. Endocr Dev 2011;21:23\u20139. https:\/\/doi.org\/10.1159\/000328117.","DOI":"10.1159\/000328117"},{"key":"2025053006390461756_j_jpem-2024-0412_ref_004","doi-asserted-by":"crossref","unstructured":"Um\u0142awska, W, Prusek-Dudkiewicz, A. Growth retardation and delayed puberty in children and adolescents with juvenile idiopathic arthritis. Arch Med Sci 2010;6:19\u201323. https:\/\/doi.org\/10.5114\/aoms.2010.13501.","DOI":"10.5114\/aoms.2010.13501"},{"key":"2025053006390461756_j_jpem-2024-0412_ref_005","doi-asserted-by":"crossref","unstructured":"Machado, SH, Xavier, RM, Lora, PS, Gon\u00e7alves, LMK, Trindade, LR, Marostica, PJC. Height and sexual maturation in girls with juvenile idiopathic arthritis. J Pediatr (Rio J) 2020;96:100\u20137. https:\/\/doi.org\/10.1016\/j.jpedp.2018.07.006.","DOI":"10.1016\/j.jped.2018.07.015"},{"key":"2025053006390461756_j_jpem-2024-0412_ref_006","doi-asserted-by":"crossref","unstructured":"Diack, ND, Ndiaye, N, Mbaye, A, Kane, BS, Leye, A. Hypogonadotropic hypogonadism and juvenile idiopathic arthritis in an african boy: what is the pathophysiological link? 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Rheumatol Int 2013;33:2123\u20136. https:\/\/doi.org\/10.1007\/s00296-013-2683-6.","DOI":"10.1007\/s00296-013-2683-6"},{"key":"2025053006390461756_j_jpem-2024-0412_ref_016","unstructured":"Zernyuk, AD, Cutusheva, GF, Kostik, MM, Masalova, VV. Analysis of menstrual dysfunction in girls suffering from juvenile idiopathic arthritis. Int J Biomed 2013;3:274\u20138."},{"key":"2025053006390461756_j_jpem-2024-0412_ref_017","doi-asserted-by":"crossref","unstructured":"El Badri, D, Rostom, S, Bouaddi, I, Hassani, A, Chkirate, B, Amine, B, et al.. Sexual maturation in Moroccan patients with juvenile idiopathic arthritis. Rheumatol Int 2014;34:665\u20138. https:\/\/doi.org\/10.1007\/s00296-013-2737-9.","DOI":"10.1007\/s00296-013-2737-9"},{"key":"2025053006390461756_j_jpem-2024-0412_ref_018","doi-asserted-by":"crossref","unstructured":"Machado, SH, Marostica, PJC, Goncalves, LM, Lora, P, Trindade, L, Xavier, RM. AB1015 sexual maturation in Brazilian girls with juvenile idiopathic. 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