{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:53:45Z","timestamp":1790182425979,"version":"4.1.0"},"reference-count":11,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jpem-2024-0542_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Acrodermatitis dysmetabolica (AD) is a dermatologic manifestation associated with inherited metabolic disorders (IMDs), distinct from acrodermatitis enteropathica, which occurs solely due to zinc deficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2024-0542_abs_002\">\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>This report presents two pediatric cases: a 30-month-old girl with maple syrup urine disease (MSUD) experiencing AD secondary to severe isoleucine deficiency due to a protein-restricted diet, showing improvement with dietary adjustments, and a 2.5-month-old boy infant with propionic acidemia (PA) who developed AD alongside septic shock, which progressed despite intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2024-0542_abs_003\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These cases emphasize the importance of identifying AD in IMDs and the critical need for meticulous monitoring of amino acid levels, as deficiencies may lead to severe complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jpem-2024-0542","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T07:31:05Z","timestamp":1736148665000},"page":"299-304","source":"Crossref","is-referenced-by-count":3,"title":["Acrodermatitis dysmetabolica: lessons from two pediatric cases"],"prefix":"10.1515","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9563-0296","authenticated-orcid":false,"given":"Ay\u00e7a Burcu","family":"Kahraman","sequence":"first","affiliation":[{"name":"Division of Pediatric Metabolism , Konya City Hospital, University of Health Sciences , Konya , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meryem S\u0131la","family":"Cosar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Konya City Hospital, University of Health Sciences , Konya , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8875-3329","authenticated-orcid":false,"given":"Ekrem Eren","family":"Dogan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine , Karatay University , Konya , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u015far","family":"\u00dcnl\u00fc","sequence":"additional","affiliation":[{"name":"Clinic of Pathology , Konya City Hospital, University of Health Sciences , Konya , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuneyt","family":"Ugur","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Konya City Hospital, University of Health Sciences , Konya , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zafer","family":"Bagc\u0131","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Konya City Hospital, University of Health Sciences , Konya , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,1,7]]},"reference":[{"key":"2025030110294543482_j_jpem-2024-0542_ref_001","doi-asserted-by":"crossref","unstructured":"K\u00fcry, S, Dr\u00e9no, B, B\u00e9zieau, S, Giraudet, S, Kharfi, M, Kamoun, R, et al.. Identification of SLC39A4, a gene involved in acrodermatitis enteropathica. Nat Genet 2002;31:239\u201340. https:\/\/doi.org\/10.1038\/ng913.","DOI":"10.1038\/ng913"},{"key":"2025030110294543482_j_jpem-2024-0542_ref_002","doi-asserted-by":"crossref","unstructured":"Maverakis, E, Fung, MA, Lynch, PJ, Draznin, M, Michael, DJ, Ruben, B, et al.. Acrodermatitis enteropathica and an overview of zinc metabolism. J Am Acad Dermatol 2007;56:116\u201324. https:\/\/doi.org\/10.1016\/j.jaad.2006.08.015.","DOI":"10.1016\/j.jaad.2006.08.015"},{"key":"2025030110294543482_j_jpem-2024-0542_ref_003","doi-asserted-by":"crossref","unstructured":"Bellini, T, Bustaffa, M, Tubino, B, Giordano, B, Formigoni, C, Fueri, E, et al.. Acquired and inherited zinc deficiency-related diseases in children: a case series and a narrative review. Pediatr Rep 2024;16:602. https:\/\/doi.org\/10.3390\/pediatric16030051.","DOI":"10.3390\/pediatric16030051"},{"key":"2025030110294543482_j_jpem-2024-0542_ref_004","doi-asserted-by":"crossref","unstructured":"Tabanl\u0131o\u011flu, D, Ersoy-Evans, S, Karaduman, A. Acrodermatitis enteropathica\u2010like eruption in metabolic disorders: acrodermatitis dysmetabolica is proposed as a better term. Pediatr Dermatol 2009;26:150\u20134. https:\/\/doi.org\/10.1111\/j.1525-1470.2008.00803.x.","DOI":"10.1111\/j.1525-1470.2008.00803.x"},{"key":"2025030110294543482_j_jpem-2024-0542_ref_005","doi-asserted-by":"crossref","unstructured":"Shipley, GD, Pittelkow, MR. Control of growth and differentiation in\u00a0vitro of human keratinocytes cultured in serum-free medium. Archiv Dermatol 1987;123:1541a\u20134a. https:\/\/doi.org\/10.1001\/archderm.1987.01660350148032.","DOI":"10.1001\/archderm.1987.01660350148032"},{"key":"2025030110294543482_j_jpem-2024-0542_ref_006","doi-asserted-by":"crossref","unstructured":"\u00d6zt\u00fcrk, F, \u00dcnl\u00fc, CI, Sar\u0131cao\u011flu, H, Aydo\u011fan, K, Erd\u00f6l, \u015e. Acrodermatitis dysmetabolica with argininosuccinate lyase deficiency. Indian J Dermatol, Venereol Leprol 2023;89:927. https:\/\/doi.org\/10.25259\/ijdvl_75_2023.","DOI":"10.25259\/IJDVL_75_2023"},{"key":"2025030110294543482_j_jpem-2024-0542_ref_007","doi-asserted-by":"crossref","unstructured":"Flores, K, Chikowski, R, Morrell, D. Acrodermatitis dysmetabolica in an infant with maple syrup urine disease. Clin Exp Dermatol 2016;41:651\u20134. https:\/\/doi.org\/10.1111\/ced.12876.","DOI":"10.1111\/ced.12876"},{"key":"2025030110294543482_j_jpem-2024-0542_ref_008","doi-asserted-by":"crossref","unstructured":"Bruni, L, Cassio, A, Di Natale, V, Baronio, F, Ortolano, R, Pession, A, et al.. A case of acrodermatitis dysmetabolica in a child affected by citrullinemia type I: when early diagnosis and timely treatment are not enough. Children 2023;10:1491. https:\/\/doi.org\/10.3390\/children10091491.","DOI":"10.3390\/children10091491"},{"key":"2025030110294543482_j_jpem-2024-0542_ref_009","doi-asserted-by":"crossref","unstructured":"Abad, RMR, Lazo-Dizon, JPH. A 1-year-old female with maple syrup urine disease presenting with acrodermatitis-enteropathica-like lesions. Acta Med Philipp 2018;52. https:\/\/doi.org\/10.47895\/amp.v52i6.289.","DOI":"10.47895\/amp.v52i6.289"},{"key":"2025030110294543482_j_jpem-2024-0542_ref_010","doi-asserted-by":"crossref","unstructured":"Santaliz-Ruiz, IVLE, Marrero-P\u00e9rez, AC, S\u00e1nchez-Pont, J, Nev\u00e1rez-Pomales, O. Acrodermatitis dysmetabolica with concomitant acquired acrodermatitis enteropathica in a patient with maple syrup urine disease. JAAD Case Rep 2024;45:7\u201310. https:\/\/doi.org\/10.1016\/j.jdcr.2023.12.009.","DOI":"10.1016\/j.jdcr.2023.12.009"},{"key":"2025030110294543482_j_jpem-2024-0542_ref_011","doi-asserted-by":"crossref","unstructured":"Alkhayal, FA, Al, HS, Bakraa, RM, Alqahtani, A. Acrodermatitis dysmetabolica secondary to isoleucine deficiency in infant with maple syrup urine disease. Dermatol Rep 2023;15. https:\/\/doi.org\/10.4081\/dr.2023.9750.","DOI":"10.4081\/dr.2023.9750"}],"container-title":["Journal of Pediatric Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2024-0542\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2024-0542\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T05:30:54Z","timestamp":1740807054000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2024-0542\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,7]]},"references-count":11,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,1,17]]},"published-print":{"date-parts":[[2025,3,26]]}},"alternative-id":["10.1515\/jpem-2024-0542"],"URL":"https:\/\/doi.org\/10.1515\/jpem-2024-0542","relation":{},"ISSN":["0334-018X","2191-0251"],"issn-type":[{"value":"0334-018X","type":"print"},{"value":"2191-0251","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,7]]}}}