{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T05:54:10Z","timestamp":1776750850033,"version":"3.51.2"},"reference-count":21,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2024-0566_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>There is limited research on thyroid function in pediatric patients with cystic fibrosis (pwCF). This study aimed to determine the frequency of thyroid dysfunction in children and adolescents with CF and to evaluate iodine deficiency and selenium status in pwCF.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2024-0566_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Sixty-two CF patients and 62 control subjects were evaluated. The anthropometric measurements, nutritional status, FEV1(Forced-expiratory-volume in 1\u202fs) percentage, thyroid function tests (TSH, FT4, FT3), urinary iodine and selenium levels, hospitalization status in the last six months, antibiotic usage, and colonization status with staphylococcus or pseudomonas were assessed for the cases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2024-0566_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The mean age of the patient group was 10.84\u00a0\u00b1\u00a04.04 years. All CF patients were receiving multivitamin supplementation. Malnutrition was present in 50\u202f% of patients, bacterial colonization in 29\u202f%, FEV1 decrease in 38.5\u202f%, subclinical hypothyroidism (SH) in 12.9\u202f%, iodine deficiency in 87\u202f% and exocrine pancreatic insufficiency in 100\u202f%. T3 levels were found to be higher in pwCF. No significant difference was found between malnutrition and FEV1 and urinary iodine and selenium levels. Compared to the control group, pwCF had lower urinary iodine levels.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2024-0566_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>To the best of our knowledge, our study is one of the few in the literature to investigate urinary selenium levels alongside iodine in PwCF. Further research is needed to clarify and interpret elevated urinary selenium levels in\u00a0this context. It was shown that iodine deficiency and the rate of SH were relatively high in pwCF. However, it was still thought that correcting iodine deficiency in these patients could improve thyroid dysfunction associated with CF.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2024-0566","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T12:23:56Z","timestamp":1737030236000},"page":"218-223","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of iodine and selenium level and thyroid functions in patients with cystic fibrosis"],"prefix":"10.1515","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9809-0977","authenticated-orcid":false,"given":"Edip","family":"Unal","sequence":"first","affiliation":[{"name":"Department of Pediatric Endocrinology , Dicle University , Diyarbak\u0131r , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8663-4826","authenticated-orcid":false,"given":"Enes","family":"Ar\u0131ca","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine , Dicle University , Diyarbak\u0131r , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2438-0602","authenticated-orcid":false,"given":"Funda Feryal","family":"Ta\u015f","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology , Dicle University , Diyarbak\u0131r , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2139-358X","authenticated-orcid":false,"given":"Bar\u0131\u015f","family":"Kolba\u015f\u0131","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology , Dicle University , Diyarbak\u0131r , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7935-0342","authenticated-orcid":false,"given":"Nurcan","family":"Beyaz\u0131t","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology , Dicle University , Diyarbak\u0131r , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2813-1064","authenticated-orcid":false,"given":"\u0130brahim","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry , Dicle University , Diyarbak\u0131r , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2733-7194","authenticated-orcid":false,"given":"Suat","family":"Sava\u015f","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Dicle University , Diyarbak\u0131r , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9232-5982","authenticated-orcid":false,"given":"Velat","family":"\u015een","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology , Dicle University , Diyarbak\u0131r , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2025,1,17]]},"reference":[{"key":"2025030110294536460_j_jpem-2024-0566_ref_001","doi-asserted-by":"crossref","unstructured":"Siwamogsatham, O, Alvarez, JA, Tangpricha, V. Diagnosis and treatment of endocrine comorbidities in patients with cystic fibrosis. Curr Opin Endocrinol Diabetes Obes 2014;21:422\u20139. https:\/\/doi.org\/10.1097\/MED.0000000000000096.","DOI":"10.1097\/MED.0000000000000096"},{"key":"2025030110294536460_j_jpem-2024-0566_ref_002","doi-asserted-by":"crossref","unstructured":"Dolan, TFJr, Gibson, LE, Gibson, LE. Complications of iodide therapy in patients with cystic fibrosis. J Pediatr 1971;79:684\u20137. https:\/\/doi.org\/10.1016\/s0022-3476(71)80324-4.","DOI":"10.1016\/S0022-3476(71)80324-4"},{"key":"2025030110294536460_j_jpem-2024-0566_ref_003","doi-asserted-by":"crossref","unstructured":"Segall-Blank, M, Vagenakis, AG, Shwachman, H, Ingbar, SH, Braverman, LE. Thyroid gland function and pituitary TSH reserve in patients with cystic fibrosis. J Pediatr 1981;98:218\u201322. https:\/\/doi.org\/10.1016\/s0022-3476(81)80638-5.","DOI":"10.1016\/S0022-3476(81)80638-5"},{"key":"2025030110294536460_j_jpem-2024-0566_ref_004","doi-asserted-by":"crossref","unstructured":"De Luca, F, Trimarchi, F, Sferlazzas, C, Benvenga, S, Costante, G, Mami, C, et al.. Thyroid function in children with cystic fibrosis. Eur J Pediatr 1982;138:327\u201330. https:\/\/doi.org\/10.1007\/bf00442510.","DOI":"10.1007\/BF00442510"},{"key":"2025030110294536460_j_jpem-2024-0566_ref_005","unstructured":"Azizi, F, Bentley, D, Vagenakis, A, Portnay, G, Bush, JE, Shwachman, H, et al.. Abnormal thyroid function and response to iodides in patients with cystic fibrosis. Trans Assoc Am Phys 1974;87:111\u201319."},{"key":"2025030110294536460_j_jpem-2024-0566_ref_006","doi-asserted-by":"crossref","unstructured":"Naehrlich, L, Dorr, HG, Bagheri-Behrouzi, A, Rauh, M. Iodine deficiency and subclinical hypothyroidism are common in cystic fibrosis patients. J Trace Elem Med Biol 2013;27:122\u20135. https:\/\/doi.org\/10.1016\/j.jtemb.2012.08.002.","DOI":"10.1016\/j.jtemb.2012.08.002"},{"key":"2025030110294536460_j_jpem-2024-0566_ref_007","doi-asserted-by":"crossref","unstructured":"Giannakopoulos, A, Katelaris, A, Noni, M, Karakonstantakis, T, Kanaka-Gantenbein, C, Doudounakis, S. Hyperthyrotropinemia in newly diagnosed cystic fibrosis patients with pancreatic insufficiency reversed by enzyme therapy. Eur J Pediatr 2018;177:775\u20139. https:\/\/doi.org\/10.1007\/s00431-018-3120-3.","DOI":"10.1007\/s00431-018-3120-3"},{"key":"2025030110294536460_j_jpem-2024-0566_ref_008","doi-asserted-by":"crossref","unstructured":"Zhang, Z, Lai, HJ. Comparison of the use of body mass index percentiles and percentage of ideal body weight to screen for malnutrition in children with cystic fibrosis. Am J Clin Nutr 2004;80:982\u201391. https:\/\/doi.org\/10.1093\/ajcn\/80.4.982.","DOI":"10.1093\/ajcn\/80.4.982"},{"key":"2025030110294536460_j_jpem-2024-0566_ref_009","doi-asserted-by":"crossref","unstructured":"Miller, MR, Hankinson, J, Brusasco, V, Burgos, F, Casaburi, R, Coates, A, et al.. Standardisation of spirometry. Eur Respir J 2005;26:319\u201338. https:\/\/doi.org\/10.1183\/09031936.05.00034805.","DOI":"10.1183\/09031936.05.00034805"},{"key":"2025030110294536460_j_jpem-2024-0566_ref_010","unstructured":"World Health Organization, UNICEF, Disorders ICfCoID. Assessment of iodine deficiency disorders and monitoring their elimination, 3rd ed. Geneva, Switzerland: World Health Organization; 2007."},{"key":"2025030110294536460_j_jpem-2024-0566_ref_011","doi-asserted-by":"crossref","unstructured":"Wolff, J, Chaikoff, IL, Goldberg, RC, Meier, JR. The temporary nature of the inhibitory action of excess iodine on organic iodine synthesis in the normal thyroid. Endocrinology 1949;45:504\u201313, illust. https:\/\/doi.org\/10.1210\/endo-45-5-504.","DOI":"10.1210\/endo-45-5-504"},{"key":"2025030110294536460_j_jpem-2024-0566_ref_012","doi-asserted-by":"crossref","unstructured":"Bath, SC, Verkaik-Kloosterman, J, Sabatier, M, Ter Borg, S, Eilander, A, Hora, K, et al.. A systematic review of iodine intake in children, adults, and pregnant women in Europe-comparison against dietary recommendations and evaluation of dietary iodine sources. Nutr Rev 2022;80:2154\u201377. https:\/\/doi.org\/10.1093\/nutrit\/nuac032.","DOI":"10.1093\/nutrit\/nuac032"},{"key":"2025030110294536460_j_jpem-2024-0566_ref_013","doi-asserted-by":"crossref","unstructured":"Knopfle, G. The thyroid hormone system in mucoviscidosis. Klin P\u00e4diatr 1985;197:481\u20138. https:\/\/doi.org\/10.1055\/s-2008-1034026.","DOI":"10.1055\/s-2008-1034026"},{"key":"2025030110294536460_j_jpem-2024-0566_ref_014","doi-asserted-by":"crossref","unstructured":"Lee, SY, Chesdachai, S, Lee, MJ, He, XM, Tangpricha, V, Braverman, LE. Thyroid function in patients with cystic fibrosis: No longer a concern? Thyroid 2016;26:875\u20139. https:\/\/doi.org\/10.1089\/thy.2015.0567 [Epub 2016 May 19].","DOI":"10.1089\/thy.2015.0567"},{"key":"2025030110294536460_j_jpem-2024-0566_ref_015","doi-asserted-by":"crossref","unstructured":"Volta, C, Street, ME, Ziveri, MA, Bonelli, P, Spaggiari, C, Grzincich, GL, et al.. Thyroid function, cytokine and IGF-IGFBP interactions in cystic fibrosis patients. Horm Res 2005;63:206\u201310. https:\/\/doi.org\/10.1159\/000085839.","DOI":"10.1159\/000085839"},{"key":"2025030110294536460_j_jpem-2024-0566_ref_016","unstructured":"Sack, J, Blau, H, Amado, O, Katznelson, D. Thyroid function in cystic fibrosis patients compared with healthy Israeli children. Isr J Med Sci 1983;19:17\u201319."},{"key":"2025030110294536460_j_jpem-2024-0566_ref_017","doi-asserted-by":"crossref","unstructured":"Zimmermann, MB, k\u00f6hrle, J. The impact of iron and selenium deficiencies on iodine and thyroid metabolism: biochemistry and relevance to public health. Thyroid 2002;12:867\u201378. https:\/\/doi.org\/10.1089\/105072502761016494.","DOI":"10.1089\/105072502761016494"},{"key":"2025030110294536460_j_jpem-2024-0566_ref_018","doi-asserted-by":"crossref","unstructured":"Fairweather-Tait, SJ, Bao, Y, Broadley, MR, Collings, R, Ford, D, Hesketh, JE, et al.. Selenium in human health and disease. Antioxidants Redox Signal 2011;14:1337\u201383. https:\/\/doi.org\/10.1089\/ars.2010.3275.","DOI":"10.1089\/ars.2010.3275"},{"key":"2025030110294536460_j_jpem-2024-0566_ref_019","doi-asserted-by":"crossref","unstructured":"Longnecker, MP, Stram, DO, Taylor, PR, Levander, OA, Howe, M, Veillon, C, et al.. Use of selenium concentration in whole blood, serum, toenails, or urine as a surrogate measure of selenium intake. Epidemiology 1996;7:384\u201390. https:\/\/doi.org\/10.1097\/00001648-199607000-00008.","DOI":"10.1097\/00001648-199607000-00008"},{"key":"2025030110294536460_j_jpem-2024-0566_ref_020","unstructured":"Yang, G, Zhou, R, Yin, S, Gu, L, Yan, B, Liu, Y, et al.. Studies of safe maximal daily dietary selenium intake in a seleniferous area in China. I. Selenium intake and tissue selenium levels of the inhabitants. J Trace Elem Electrolytes Health & Dis 1989;3:77\u201387."},{"key":"2025030110294536460_j_jpem-2024-0566_ref_021","doi-asserted-by":"crossref","unstructured":"Mutonhodza, B, Dembedza, MP, Joy, EJM, Manzeke-Kangara, MG, Njovo, H, Nyadzayo, TK, et al.. Urine Se concentration poorly predicts plasma Se concentration at sub-district scales in Zimbabwe, limiting its value as a biomarker of population Se status. 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