{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T14:58:08Z","timestamp":1771772288517,"version":"3.50.1"},"reference-count":56,"publisher":"Walter de Gruyter GmbH","issue":"6","funder":[{"name":"National Natural Science Foundation of Hebei","award":["H2022307076"],"award-info":[{"award-number":["H2022307076"]}]},{"name":"Hebei Province 2023 medical scientific research project","award":["20230016"],"award-info":[{"award-number":["20230016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jpem-2024-0617_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Central precocious puberty (CPP) is one of the common endocrine diseases in pediatrics. However, the molecular mechanisms regulating development of CPP have remained unclear. The purpose of this study was to discover the key pathways and hub genes related to CPP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2024-0617_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed two public datasets (GSE7142 and GSE8310) to identify differentially expressed genes in the progression of CPP. Then, we screened out overlapping differential genes from these two datasets and performed a\u00a0series of bioinformatics analyses to explore promising targets and molecule mechanism of CPP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2024-0617_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 30 down-regulated overlapping DEGs between GSE7142 (CPP\/no CPP) and GSE8130 (EP\/JUV) datasets and 17 down-regulated overlapping DEGs between GSE7142 (CPP\/no CPP) and GSE8130 (LP\/JUV) datasets. KEGG signaling pathway shows that calcium signaling pathway is suppressed continuously in early and late pubertal of CPP patients. MAPK signaling pathway also plays an important role in the occurrence and development of CPP. Eventually, we screened out 2 hub genes (\n                      <jats:italic>FGFR2 and FLT1<\/jats:italic>\n                      ) highly related to CPP, which may provide a new directions for the diagnosis and treatment of CPP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2024-0617_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While further validation is needed, we provide useful and novel information to explore potential signaling pathways and candidate genes for CPP diagnosis and treatment options.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jpem-2024-0617","type":"journal-article","created":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T06:15:55Z","timestamp":1742451355000},"page":"615-623","source":"Crossref","is-referenced-by-count":0,"title":["Bioinformatics analysis explores key pathways and hub genes in central precocious puberty"],"prefix":"10.1515","volume":"38","author":[{"given":"Na","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Internal Medicine , Hebei Medical University , Shijiazhuang , Hebei , China"},{"name":"Department of Endocrinology, The First Hospital of Hebei Medical University , Shijiazhuang , Hebei , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine , Hebei Medical University , Shijiazhuang , Hebei , China"},{"name":"Department of Endocrinology, The First Hospital of Hebei Medical University , Shijiazhuang , Hebei , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhong","family":"He","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine , Hebei Medical University , Shijiazhuang , Hebei , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linlin","family":"Yang","sequence":"additional","affiliation":[{"name":"Data Center, The First Hospital of Hebei Medical University , Shijiazhuang , Hebei , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huijuan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine , Hebei Medical University , Shijiazhuang , Hebei , China"},{"name":"Department of Endocrinology, The First Hospital of Hebei Medical University , Shijiazhuang , Hebei , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"key":"2026022213585092430_j_jpem-2024-0617_ref_001","unstructured":"Shiva, S, Fayyazi, A, Melikian, A, Shiva, S. 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