{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T07:10:01Z","timestamp":1748589001537,"version":"3.41.0"},"reference-count":31,"publisher":"Walter de Gruyter GmbH","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2025-0037_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Glucocorticoid excess or deficiency with hyperandrogenism may cause cardiovascular morbidity in patients with congenital adrenal hyperplasia (CAH) due to failing to mimic physiological circadian rhythm. This study aimed to evaluate the cardiac function in pediatric patients with CAH treated with conventional hydrocortisone treatment and its relation to hydrocortisone dose and therapy duration.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2025-0037_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Twenty-three pediatric patients with CAH, aged 3\u201316 years, and 21 age- and gender-matched healthy controls were enrolled to the study. All the patients were evaluated by physical examination, electrocardiogram (ECG), conventional echocardiography, and tissue Doppler imaging (TDI).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2025-0037_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The mean Sm (systolic myocardial velocity) in the CAH group was 7.96\u00a0\u00b1\u00a01.22\u202fcm\/s, which was significantly lower than that in the control group (p=0.034). The mean systolic excursion in the CAH group was 14.17\u00a0\u00b1\u00a01.92\u202fmm, which was significantly lower than that in the control group (p=0.046). The tricuspid-derived early diastolic myocardial velocity (Em) and the tricuspid-derived E\/Em ratio were significantly higher in the CAH group than in the control group (p=0.003 and 0.008, respectively). No signs of left ventricular hypertrophy or dilatation were detected on ECG and echocardiography.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2025-0037_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Long-term conventional hydrocortisone therapy even within the recommended therapeutic range may adversely affect cardiac functions in children with 21-hydroxylase deficiency.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2025-0037","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T13:03:50Z","timestamp":1744117430000},"page":"637-643","source":"Crossref","is-referenced-by-count":0,"title":["Cardiac function in children with congenital adrenal hyperplasia"],"prefix":"10.1515","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7702-8296","authenticated-orcid":false,"given":"Tu\u011fba Kontbay","family":"\u00c7etin","sequence":"first","affiliation":[{"name":"Department of Paediatric Endocrinology , \u015eanl\u0131urfa Training and Research Hospital , \u015eanl\u0131urfa , T\u00fcrkiye"},{"name":"Department of Paediatric Endocrinology , Samsun Training and Resarch Hospital , Samsun , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulkadir","family":"Akku\u015f","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology , \u015eanl\u0131urfa Training and Research Hospital , \u015eanl\u0131urfa , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9153-8580","authenticated-orcid":false,"given":"M\u00fcge","family":"Atar","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology , \u015eanl\u0131urfa Training and Research Hospital , \u015eanl\u0131urfa , T\u00fcrkiye"},{"name":"Department of Paediatric Endocrinology , Antalya Training and Research Hospital , Antalya , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2025,4,8]]},"reference":[{"key":"2025053006390458998_j_jpem-2025-0037_ref_001","doi-asserted-by":"crossref","unstructured":"Turan, I, Tastan, M, Boga, DD, Gurbuz, F, Kotan, LD, Tuli, A, et al.. 21-hydroxylase deficiency: mutational spectrum and genotype-phenotype relations analyses by next-generation sequencing and multiplex ligation-dependent probe amplification. 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