{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:15:41Z","timestamp":1791976541116,"version":"4.4.0"},"reference-count":65,"publisher":"Walter de Gruyter GmbH","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2025-0057_abs_001\">\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Recombinant human growth hormone (rhGH) therapy (GHT) for short stature resulting from growth hormone deficiency (GHD) is effective in promoting optimal growth velocity and achieving an appropriate final height. However, the specific metabolic changes in children during replacement GHT remain unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2025-0057_abs_002\">\n                  <jats:title>Content<\/jats:title>\n                  <jats:p>The study aimed to evaluate the effects of GHT on metabolism in children with GHD. This is a review of the literature published at PubMed\/MEDLINE between January 2010 and August 2024, including original articles. The authors searched Medline using the following keywords: growth hormone therapy in children OR growth hormone treatment in children AND metabolism OR glycemia OR glycated hemoglobin OR insulin OR lipid profile OR blood pressure OR bone mineral density OR body mass index OR waist circumference OR hip circumference OR waist-to-hip ratio OR lean body mass OR visceral fat OR muscle strength OR physical activity OR exercise.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2025-0057_abs_003\">\n                  <jats:title>Summary and Outlook<\/jats:title>\n                  <jats:p>GHT in children positively affects the lipid profile and body composition. Nevertheless, rhGH treatment may increase fasting glucose, glycated hemoglobin, and indices of insulin resistance. GHT in children has not been associated with an increased risk of diabetes. No changes in blood pressure during GHT were observed. The results of our review show that GHT impacts lipid profiles, carbohydrate metabolism, and body composition. Further studies are needed to clarify the molecular mechanisms by which GH regulates substrate metabolism.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2025-0057","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:59:56Z","timestamp":1746406796000},"page":"796-806","source":"Crossref","is-referenced-by-count":5,"title":["Biological effects of recombinant human growth hormone therapy on metabolism in children with growth hormone deficiency: a review"],"prefix":"10.1515","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0384-1692","authenticated-orcid":false,"given":"Kamil","family":"Dyrka","sequence":"first","affiliation":[{"name":"Poznan University of Medical Sciences, Doctoral School, Department of Pediatric Endocrinology and Rheumatology, Institute of Pediatrics , Poznan , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamila","family":"\u0141achut","sequence":"additional","affiliation":[{"name":"Greater Poland Pediatric Center , Poznan , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zofia","family":"Kolesi\u0144ska","sequence":"additional","affiliation":[{"name":"Poznan University of Medical Sciences, Department of Pediatric Endocrinology and Rheumatology, Institute of Pediatrics , Poznan , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Niedziela","sequence":"additional","affiliation":[{"name":"Poznan University of Medical Sciences, Department of Pediatric Endocrinology and Rheumatology, Institute of Pediatrics , Poznan , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Obara-Moszy\u0144ska","sequence":"additional","affiliation":[{"name":"Poznan University of Medical Sciences, Department of Pediatric Endocrinology and Rheumatology, Institute of Pediatrics , Poznan , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,5,6]]},"reference":[{"key":"2025080412565949993_j_jpem-2025-0057_ref_001","doi-asserted-by":"crossref","unstructured":"Ipsa, E, Cruzat, VF, Kagize, JN, Yovich, JL, Keane, KN. 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