{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:40:16Z","timestamp":1783489216202,"version":"3.55.0"},"reference-count":31,"publisher":"Walter de Gruyter GmbH","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jpem-2025-0162_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aims to characterize the clinical spectrum of pediatric adrenocortical tumors (P-ACTs) in individuals aged &lt;20\u00a0years and to compare the distinguishing features of pediatric adrenocortical adenomas (P-ACAs) and carcinomas (P-ACCs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2025-0162_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study consisted of P-ACT patients who presented to our institute over the past 24\u00a0years (2001\u20132024). They were categorized as P-ACC or P-ACA based on Wieneke score. Data on clinical presentation, hormonal evaluation, imaging, management, and outcomes were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2025-0162_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 30 (22 females) P-ACT patients (7\u00a0P-ACA and 23 P-ACC) were identified. The median age at presentation was 7 (range, 1.0\u201320) years, with a median symptom duration of 6.0\u00a0months (range 0.6\u201342\u00a0months). All patients, except one 16-year-old having P-ACC, had hormonal hypersecretion. Cortisol and androgen co-secretion was most common (56.6\u202f%), followed by isolated cortisol (26.6\u202f%) and androgen hypersecretion (13.3\u202f%). On steroid profiling by LCMS\/MS, P-ACC patients had raised levels of multiple steroid metabolites (6\u20139) as compared to P-ACA (2\u20135). P-ACA patients were relatively older (17.0 vs. 6.0 years, p=0.045), more often had isolated cortisol secretion (57.1 vs. 17.3\u202f%, p=0.060), had smaller tumors (2.8 vs. 8.5\u202fcm, p=0.002), a lower incidence of calcification (0 vs. 80\u202f%) and a lower percentage venous enhancement (PVE 109.6 vs. 187.8\u202f%, p=0.008) and achieved higher disease remission rates (100 vs. 21.4\u202f%, p=0.005).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2025-0162_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CECT features, particularly PVE, may aid in differentiating P-ACT from P-ACC. Serum steroid panels may have a role in preoperative assessment, but their utility remains to be validated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jpem-2025-0162","type":"journal-article","created":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T05:55:42Z","timestamp":1755928542000},"page":"1059-1067","source":"Crossref","is-referenced-by-count":1,"title":["Clinical spectrum, imaging characteristics, and treatment outcomes of pediatric adrenocortical tumors: a 24-year experience from Western India"],"prefix":"10.1515","volume":"38","author":[{"given":"Aaditya","family":"Daga","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism , 29549 Seth G S Medical College and KEM Hospital , Mumbai , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddhant","family":"Dahale","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism , 29549 Seth G S Medical College and KEM Hospital , Mumbai , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Phadte","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism , 29549 Seth G S Medical College and KEM Hospital , Mumbai , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay","family":"Sarathi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology , Vydehi Institute of Medical Sciences and Research Centre , Bangalore , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saba","family":"Memon","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism , 29549 Seth G S Medical College and KEM Hospital , Mumbai , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9623-4471","authenticated-orcid":false,"given":"Anurag","family":"Lila","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism , 29549 Seth G S Medical College and KEM Hospital , Mumbai , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chethan","family":"Yamichannaiah","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism , 29549 Seth G S Medical College and KEM Hospital , Mumbai , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virendra","family":"Patil","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism , 29549 Seth G S Medical College and KEM Hospital , Mumbai , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjiri","family":"Karlekar","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism , 29549 Seth G S Medical College and KEM Hospital , Mumbai , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Barnabas","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism , 29549 Seth G S Medical College and KEM Hospital , Mumbai , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nalini","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism , 29549 Seth G S Medical College and KEM Hospital , Mumbai , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amey","family":"Rojekar","sequence":"additional","affiliation":[{"name":"Department of Pathology , Seth GSMC and KEMH , Mumbai , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwendolyn","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Department of Pathology , Seth GSMC and KEMH , Mumbai , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pragati","family":"Sathe","sequence":"additional","affiliation":[{"name":"Department of Pathology , Seth GSMC and KEMH , Mumbai , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padma","family":"Badhe","sequence":"additional","affiliation":[{"name":"Department of Radiology , Seth GSMC and KEMH , Mumbai , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6902-4639","authenticated-orcid":false,"given":"Tushar","family":"Bandgar","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism , 29549 Seth G S Medical College and KEM Hospital , Mumbai , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,8,25]]},"reference":[{"key":"2025111210012234040_j_jpem-2025-0162_ref_001","doi-asserted-by":"crossref","unstructured":"Ilanchezhian, M, Varghese, DG, Glod, JW, Reilly, KM, Widemann, BC, Pommier, Y, et al.. 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