{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T21:32:14Z","timestamp":1758144734852,"version":"3.44.0"},"reference-count":28,"publisher":"Walter de Gruyter GmbH","issue":"9","funder":[{"name":"Ministry of Science and Research of North Rhine-Westphalia"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2025-0225_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To generate current reference values for height velocity (HV, cm\/year) in German children and adolescents and to evaluate the sensitivity of auxological parameters in the evaluation of short stature (referral criteria).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2025-0225_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The study population consisted of healthy German participants of the Dortmund Nutritional and Anthropometric Longitudinally Designed (DONALD) study (1985\u20132022). In total, data was available from n=453 girls (mean age 9.1\u00a0\u00b1\u00a02.4 years) and n=473 boys (mean age of 9.6\u00a0\u00b1\u00a02.5 years). As the participants were measured repeatedly, 4,557\u202fHV assessments for girls and 5,224\u202fHV assessments for boys were analyzed (median number of observations in female was nine and in male 11). The reference percentiles were created using the LMS method. The referral criteria of the German Society for Pediatric and Adolescent Endocrinology and Diabetology (DGPAED) and of the Growth Hormone Research Society (GHRS) for further endocrinological evaluation were evaluated in a subsample.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2025-0225_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The specificity of the referral criteria \u201cHV&lt;25th centile for 1\u00a0year\u201d (DGPAED) was 10.4\u202f% in girls and 4.3\u202f% in boys. When this criterion was changed to \u201cHV&lt;3rd centile for 1\u00a0year\u201d the specificity increased to 75.5\u202f% in girls and 76.1\u202f% in boys. With omission of the 5th criterion (\u201cheight&gt;\u00a0\u22122.0 SD AND HV&lt;\u00a0\u22122.0 over 1\u00a0year\u201d) of the six referral criteria of the GHRS, the specificity of the remaining five referral criteria was 91.4\u202f% in girls and 90.5\u202f% in\u00a0boys.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2025-0225_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>New reference centiles for HV are presented. With modification of the already proposed GHRS criteria, the specificity of the assessment of HV in the evaluation of short stature could be increased significantly.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2025-0225","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T06:55:48Z","timestamp":1750834548000},"page":"887-897","source":"Crossref","is-referenced-by-count":0,"title":["Height velocity in the detection of growth disorders reconsidered: a retrospective analysis of the DONALD study"],"prefix":"10.1515","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4044-8822","authenticated-orcid":false,"given":"Ibrahim","family":"Duran","sequence":"first","affiliation":[{"name":"14309 Center of Prevention and Rehabilitation, University of Cologne, Medical Faculty and University Hospital, UniReha , Cologne , Germany"},{"name":"Department of Pediatrics , University of Cologne, Medical Faculty and University Hospital , Cologne , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"14309 Center of Prevention and Rehabilitation, University of Cologne, Medical Faculty and University Hospital, UniReha , Cologne , Germany"},{"name":"Department of Pediatrics , University of Cologne, Medical Faculty and University Hospital , Cologne , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Buggisch","sequence":"additional","affiliation":[{"name":"14309 Center of Prevention and Rehabilitation, University of Cologne, Medical Faculty and University Hospital, UniReha , Cologne , Germany"},{"name":"Department of Pediatrics , University of Cologne, Medical Faculty and University Hospital , Cologne , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heike","family":"Hoyer-Kuhn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , University of Cologne, Medical Faculty and University Hospital , Cologne , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ute","family":"Alexy","sequence":"additional","affiliation":[{"name":"Institute of Nutritional and Food Sciences-Nutritional Epidemiology, DONALD Study, University of Bonn , Dortmund , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eckhard","family":"Schoenau","sequence":"additional","affiliation":[{"name":"14309 Center of Prevention and Rehabilitation, University of Cologne, Medical Faculty and University Hospital, UniReha , Cologne , Germany"},{"name":"Department of Pediatrics , University of Cologne, Medical Faculty and University Hospital , Cologne , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2025,6,20]]},"reference":[{"key":"2025091715550579645_j_jpem-2025-0225_ref_001","unstructured":"Binder, GWJ. S1-Leitlinie Kleinwuchs [short stature] [stand: 13.08; 2024. Available from: https:\/\/register.awmf.org\/assets\/guidelines\/174-004l_S1_Kleinwuchs_2023-07.pdf."},{"key":"2025091715550579645_j_jpem-2025-0225_ref_002","doi-asserted-by":"crossref","unstructured":"Society GR. Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: summary statement of the GH research society. J\u00a0Clin Endocrinol Metab 2000;85:3990\u20133. https:\/\/doi.org\/10.1210\/jc.85.11.3990.","DOI":"10.1210\/jc.85.11.3990"},{"key":"2025091715550579645_j_jpem-2025-0225_ref_003","doi-asserted-by":"crossref","unstructured":"Brandt, I, Reinken, L. Die Wachstumsgeschwindigkeit gesunder Kinder in den ersten 16 Lebensjahren: longitudinale Entwicklungsstudie Bonn\u00a0\u2013\u00a0Dortmund [The growth rate of healthy children in the first 16\u00a0years of life: longitudinal developmental study Bonn\u00a0\u2013\u00a0Dortmund]. Klin P\u00e4diatr 1988;200:451\u20136. https:\/\/doi.org\/10.1055\/s-2008-1033752.","DOI":"10.1055\/s-2008-1033752"},{"key":"2025091715550579645_j_jpem-2025-0225_ref_004","unstructured":"Reinken, L, van, OG. Longitudinal physical development of healthy children 0 to 18\u00a0years of age. Body length\/height, body weight and growth velocity. Klin P\u00e4diatr 1992;204. Verf\u00fcgbar unter: https:\/\/pubmed.ncbi.nlm.nih.gov\/1614176\/."},{"key":"2025091715550579645_j_jpem-2025-0225_ref_005","doi-asserted-by":"crossref","unstructured":"Hesse, V, Schnabel, O, Judis, E, Cammann, H, Hinkel, J, Weissenborn, J. L\u00e4ngsschnittstudie des aktuellen Wachstums 0- bis 6-j\u00e4hriger deutscher Kinder: Teil 1 [Longitudinal study of the current growth of 0- to 6-year-old German children: Part 1]. Monatsschr Kinderheilkd 2016;164:478\u201396. https:\/\/doi.org\/10.1007\/s00112-016-0067-1.","DOI":"10.1007\/s00112-016-0067-1"},{"key":"2025091715550579645_j_jpem-2025-0225_ref_006","doi-asserted-by":"crossref","unstructured":"Cole, TJ. Secular trends in growth. Proc Nutr Soc 2000;59:317\u201324. https:\/\/doi.org\/10.1017\/s0029665100000355.","DOI":"10.1017\/S0029665100000355"},{"key":"2025091715550579645_j_jpem-2025-0225_ref_007","doi-asserted-by":"crossref","unstructured":"Gohlke, B, Woelfle, J. Growth and puberty in German children: is there still a positive secular trend? Dtsch Arztebl Int 2009;106:377\u201382. https:\/\/doi.org\/10.3238\/arztebl.2009.0377.","DOI":"10.3238\/arztebl.2009.0656b"},{"key":"2025091715550579645_j_jpem-2025-0225_ref_008","doi-asserted-by":"crossref","unstructured":"Rubin, C, Maisonet, M, Kieszak, S, Monteilh, C, Holmes, A, Flanders, D, et al.. Timing of maturation and predictors of menarche in girls enrolled in a contemporary British cohort. Paediatr Perinat Epidemiol 2009;23. https:\/\/doi.org\/10.1111\/j.1365-3016.2009.01055.x.","DOI":"10.1111\/j.1365-3016.2009.01055.x"},{"key":"2025091715550579645_j_jpem-2025-0225_ref_009","doi-asserted-by":"crossref","unstructured":"S\u00f8rensen, K, Aksglaede, L, Petersen, JH, Juul, A. Recent changes in pubertal timing in healthy Danish boys: associations with body mass index. J\u00a0Clin Endocrinol Metab 2010;95. https:\/\/doi.org\/10.1210\/jc.2009-1478.","DOI":"10.1210\/jc.2009-1478"},{"key":"2025091715550579645_j_jpem-2025-0225_ref_010","unstructured":"German clinical trial register. Dortmund nutritional and anthropometric longitudinally designed study [stand: 18.09.2023]. Available from: https:\/\/drks.de\/search\/de\/trial\/DRKS00029092."},{"key":"2025091715550579645_j_jpem-2025-0225_ref_011","doi-asserted-by":"crossref","unstructured":"Perrar, I, Alexy, U, N\u00f6thlings, U. Cohort profile update\u2013overview of over 35\u00a0years of research in the Dortmund nutritional and anthropometric longitudinally designed (DONALD) study. Eur J Nutr 2024;63:727\u201340. https:\/\/doi.org\/10.1007\/s00394-023-03290-x.","DOI":"10.1007\/s00394-023-03290-x"},{"key":"2025091715550579645_j_jpem-2025-0225_ref_012","doi-asserted-by":"crossref","unstructured":"Kroke, A, Manz, F, Kersting, M, Remer, T, Sichert-Hellert, W, Alexy, U, et al.. The DONALD Study. History, current status and future perspectives. Eur J Nutr 2004;43. https:\/\/doi.org\/10.1007\/s00394-004-0445-7.","DOI":"10.1007\/s00394-004-0445-7"},{"key":"2025091715550579645_j_jpem-2025-0225_ref_013","doi-asserted-by":"crossref","unstructured":"Tanner, JM, Whitehouse, RH, Marshall, WA, Carter, BS. Prediction of adult height from height, bone age, and occurrence of menarche, at ages 4 to 16 with allowance for midparent height. Arch Dis Child 1975;50. https:\/\/doi.org\/10.1136\/adc.50.1.14.","DOI":"10.1136\/adc.50.1.14"},{"key":"2025091715550579645_j_jpem-2025-0225_ref_014","unstructured":"Tanner, JM, Hrsg. Assessment of skeletal maturity and prediction of adult height (TW2 method), 2nd ed. London, New York: Academic Press; 1984:\u00a91983 p."},{"key":"2025091715550579645_j_jpem-2025-0225_ref_015","doi-asserted-by":"crossref","unstructured":"Hermanussen, M, Cole, J. The calculation of target height reconsidered. Horm Res 2003;59:180\u20133. https:\/\/doi.org\/10.1159\/000069321.","DOI":"10.1159\/000069321"},{"key":"2025091715550579645_j_jpem-2025-0225_ref_016","unstructured":"Neuhauser, H, Schienkiewitz, A, Schaffrath, AR, Dortschy, R, Kurth, BM. Referenzperzentile f\u00fcr anthropometrische Ma\u00dfzahlen und Blutdruck aus der Studie zur Gesundheit von Kindern und Jugendlichen in Deutschland (KiGGS) [Reference percentiles for anthropometric measures and blood pressure from the German Health Interview and Examination Survey for Children and Adolescents (KiGGS)]. Gesundheitsbericht Des Bundes 2013;2:12\u201323."},{"key":"2025091715550579645_j_jpem-2025-0225_ref_017","doi-asserted-by":"crossref","unstructured":"Cole, T, Green, P. Smoothing reference centile curves: the LMS method and penalized likelihood. Stat Med 1992;11:1305\u201319. https:\/\/doi.org\/10.1002\/sim.4780111005.","DOI":"10.1002\/sim.4780111005"},{"key":"2025091715550579645_j_jpem-2025-0225_ref_018","doi-asserted-by":"crossref","unstructured":"Rigby, RA, Stasinopoulos, DM. Generalized additive models for location, scale and shape. J\u00a0Roy Stat Soc Series C (Appl Statistics) 2005;54:507\u201354. https:\/\/doi.org\/10.1111\/j.1467-9876.2005.00510.x.","DOI":"10.1111\/j.1467-9876.2005.00510.x"},{"key":"2025091715550579645_j_jpem-2025-0225_ref_019","doi-asserted-by":"crossref","unstructured":"Royston, P, Wright, EM. Goodness-of-fit statistics for age-specific reference intervals. Stat Med 2000;19. https:\/\/doi.org\/10.1002\/1097-0258(20001115)19:21<2943::aid-sim559>3.0.co;2-5.","DOI":"10.1002\/1097-0258(20001115)19:21<2943::AID-SIM559>3.0.CO;2-5"},{"key":"2025091715550579645_j_jpem-2025-0225_ref_020","doi-asserted-by":"crossref","unstructured":"van, BS, Fredriks, M. Worm plot: a simple diagnostic device for modelling growth reference curves. Stat Med 2001;20. https:\/\/doi.org\/10.1002\/sim.746.","DOI":"10.1002\/sim.746"},{"key":"2025091715550579645_j_jpem-2025-0225_ref_021","unstructured":"De, OM. WHO child growth standards - length\/height-for-age, weight-for-age, weight-for-length. In: Weight-for-height and body mass index-for age: methods and development. Geneva: World Health Organization; 2006."},{"key":"2025091715550579645_j_jpem-2025-0225_ref_022","unstructured":"Prader, A, Largo, RH, Molinari, L, Issler, C. Physical growth of Swiss children from birth to 20\u00a0years of age. First Zurich longitudinal study of growth and development. Helv Paediatr Acta Suppl 1989;52:1\u2013125."},{"key":"2025091715550579645_j_jpem-2025-0225_ref_023","doi-asserted-by":"crossref","unstructured":"Cheng, TS, Ong, KK, Biro, FM. Trends toward earlier puberty timing in girls and its likely mechanisms. J\u00a0Pediatr Adolesc Gynecol 2022;35:527\u201331. https:\/\/doi.org\/10.1016\/j.jpag.2022.04.009.","DOI":"10.1016\/j.jpag.2022.04.009"},{"key":"2025091715550579645_j_jpem-2025-0225_ref_024","doi-asserted-by":"crossref","unstructured":"Brook, CG, Hindmarsh, PC, Healy, MJ. A better way to detect growth failure. Br Med J (Clin Res ed.) 1986;293. https:\/\/doi.org\/10.1136\/bmj.293.6556.1186.","DOI":"10.1136\/bmj.293.6556.1186"},{"key":"2025091715550579645_j_jpem-2025-0225_ref_025","doi-asserted-by":"crossref","unstructured":"Scherdel, P, Matczak, S, L\u00e9ger, J, Martinez-Vinson, C, Goulet, O, Brauner, R, et al.. Algorithms to define abnormal growth in children: external validation and head-to-head comparison. J\u00a0Clin Endocrinol Metab 2019;104:241\u20139. https:\/\/doi.org\/10.1210\/jc.2018-00723.","DOI":"10.1210\/jc.2018-00723"},{"key":"2025091715550579645_j_jpem-2025-0225_ref_026","doi-asserted-by":"crossref","unstructured":"Grote, FK, van, DP, Oostdijk, W, de, MK-SS, Verkerk, PH, Wit, JM, et al.. Developing evidence-based guidelines for referral for short stature. Arch Dis Child 2008;93. Verf\u00fcgbar unter: https:\/\/pubmed.ncbi.nlm.nih.gov\/17908714\/.","DOI":"10.1136\/adc.2007.120188"},{"key":"2025091715550579645_j_jpem-2025-0225_ref_027","doi-asserted-by":"crossref","unstructured":"Gascoin-Lachambre, G, Brauner, R, Duche, L, Chalumeau, M. Pituitary stalk interruption syndrome: diagnostic delay and sensitivity of the auxological criteria of the growth hormone research society. PLoS One 2011;6:e16367. https:\/\/doi.org\/10.1371\/journal.pone.0016367.","DOI":"10.1371\/journal.pone.0016367"},{"key":"2025091715550579645_j_jpem-2025-0225_ref_028","doi-asserted-by":"crossref","unstructured":"Voss, LD, Wilkin, TJ, Bailey, BJ, Betts, PR. The reliability of height and height velocity in the assessment of growth (the Wessex Growth Study). Arch Dis Child 1991;66. https:\/\/doi.org\/10.1136\/adc.66.7.833.","DOI":"10.1136\/adc.66.7.833"}],"container-title":["Journal of Pediatric Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jpem-2025-0225\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jpem-2025-0225\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T15:57:08Z","timestamp":1758124628000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jpem-2025-0225\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,20]]},"references-count":28,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,7,10]]},"published-print":{"date-parts":[[2025,9,25]]}},"alternative-id":["10.1515\/jpem-2025-0225"],"URL":"https:\/\/doi.org\/10.1515\/jpem-2025-0225","relation":{},"ISSN":["0334-018X","2191-0251"],"issn-type":[{"type":"print","value":"0334-018X"},{"type":"electronic","value":"2191-0251"}],"subject":[],"published":{"date-parts":[[2025,6,20]]}}}