{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T10:05:38Z","timestamp":1762941938538,"version":"3.45.0"},"reference-count":38,"publisher":"Walter de Gruyter GmbH","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jpem-2025-0320_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study retrospectively evaluated long-term clinical and biochemical findings in children and adolescents diagnosed with Hashimoto\u2019s thyroiditis\u00a0(HT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2025-0320_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 233 patients aged 2\u201318 years, diagnosed with HT and followed for at least three years, were included. Patients were classified into five subgroups based on thyroid stimulating hormone (TSH) and free thyroxine (fT4) levels at diagnosis. Clinical, laboratory, and radiological findings at baseline and during follow-up were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2025-0320_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The most common initial thyroid status was subclinical hypothyroidism (SCH) (39.5\u202f%), followed by euthyroidism (36.5\u202f%), overt hypothyroidism (OH) (18.5\u202f%), subclinical hyperthyroidism (3.9\u202f%), and overt hyperthyroidism (1.7\u202f%). Data from 173 patients were available at the third and fifth years. Total of 48.4\u202f% of patients were monitored without treatment, 47.6\u202f% were initiated on levothyroxine and 3\u202f% were initiated on methimazole. Among OH patients, 9\u202f% became euthyroid over time and discontinued treatment. Levothyroxine was initiated in 73.6\u202f% of SCH patients, but only one discontinued treatment due to normalization. Among 63 untreated patients following for five years, no functional deterioration was observed. While autoantibody levels remained stable across all groups at year three, both TPO-Ab and TG-Ab levels significantly decreased by year five (p=0.000).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2025-0320_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Given its dynamic nature, HT requires continuous monitoring through regular clinical assessments and thyroid function testing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jpem-2025-0320","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T14:00:31Z","timestamp":1756735231000},"page":"1078-1085","source":"Crossref","is-referenced-by-count":0,"title":["Hashimoto\u2019s thyroiditis in children and adolescents: analysis of long-term course"],"prefix":"10.1515","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3335-7976","authenticated-orcid":false,"family":"Ay\u015fe Ya\u015far","sequence":"first","affiliation":[{"name":"Department of Pediatric Endocrinology , University of Health Science Umraniye Training and Research Hospital , Istanbul , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8663-3452","authenticated-orcid":false,"family":"Heves K\u0131rm\u0131z\u0131bekmez","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology , University of Health Science Umraniye Training and Research Hospital , Istanbul , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5578-1770","authenticated-orcid":false,"family":"Esma Ebru Altun","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology , Dr. \u0130smail Fehmi Cumal\u0131o\u011flu City Hospital , Tekirda\u011f , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2678-3886","authenticated-orcid":false,"family":"Fatma G\u00fcliz Atmaca","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology , University of Health Science Umraniye Training and Research Hospital , Istanbul , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6844-5653","authenticated-orcid":false,"family":"\u015eerife Ece Ulu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology , University of Health Science Umraniye Training and Research Hospital , Istanbul , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0614-4083","authenticated-orcid":false,"family":"G\u00fclcan Seymen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology , Ac\u0131badem Altunizade Hospital , Istanbul , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0483-7986","authenticated-orcid":false,"family":"Burcu C\u00fcce","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology , University of Health Science Umraniye Training and Research Hospital , Istanbul , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8200-087X","authenticated-orcid":false,"family":"Zehra Sucu Saymaz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology , University of Health Science Umraniye Training and Research Hospital , Istanbul , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Fatma Dursun","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology , University of Health Science Umraniye Training and Research Hospital , Istanbul , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2025,9,1]]},"reference":[{"key":"2025111210012231538_j_jpem-2025-0320_ref_001","doi-asserted-by":"crossref","unstructured":"De Luca, F, Santucci, S, Corica, D, Pitrolo, E, Romeo, M, Aversa, T. 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