{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T15:59:59Z","timestamp":1771516799178,"version":"3.50.1"},"reference-count":20,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jpem-2025-0395_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Growth hormone (GH) therapy in children with idiopathic short stature (ISS) and partial GH deficiency increases adult height. However, the benefit of continuing GH therapy through puberty is unclear. We aimed to assess whether GH therapy improves adult height compared to predicted adult height (PAH) at puberty\u00a0onset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2025-0395_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a multicenter retrospective chart review of patients with ISS and partial GH deficiency. GH therapy began before or at the onset of puberty and continued until height velocity was &lt;2.5\u202fcm\/year. Bone age and PAH at different treatment time points were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2025-0395_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>About 60\u202f% of the 72 patients started GH before puberty. The mean duration of GH therapy was 3.5\u00a0years in girls and 4.6\u00a0years in boys. The mean PAH gain from GH start to puberty onset was 8\u202fcm for boys (p&lt;0.01) and 3.1\u202fcm for girls (p&lt;0.01). The mean difference between near adult height and PAH at puberty onset (\u0394HDP) was\u00a0\u22120.62\u202fcm\u202f(p=0.75) for boys and 1.82\u202fcm for girls (p=0.07). A higher bone age to chronological age ratio at therapy start (p&lt;0.01), higher body mass index standard deviation score (SDS) at therapy start (p&lt;0.05), higher mid-parental height (p&lt;0.05), and longer duration of pubertal GH therapy (p&lt;0.05) were associated with a greater \u0394HDP, whereas a higher height SDS at the onset of puberty (p&lt;0.01) and a higher IGF-1 SDS at therapy start (p&lt;0.01) were associated with a smaller increase. Peak GH levels and sex were not statistically significant predictors. The average cost for the final year of GH therapy was $122,000.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2025-0395_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While GH therapy before puberty increases PAH, continuing treatment through puberty did not, on average, yield further height benefit and was costly. Physicians might consider whether to continue GH therapy once a child appears to have reached an adequate\u00a0PAH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jpem-2025-0395","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T17:00:11Z","timestamp":1767027611000},"page":"118-125","source":"Crossref","is-referenced-by-count":0,"title":["Do patients with idiopathic short stature or partial growth hormone deficiency need to continue growth hormone therapy during puberty?"],"prefix":"10.1515","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4986-6000","authenticated-orcid":false,"given":"Sena","family":"Cantas-Orsdemir","sequence":"first","affiliation":[{"name":"Department of Pediatrics\/Division of Endocrinology , Loma Linda University Children\u2019s Hospital , Loma Linda , CA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adem","family":"Orsdemir","sequence":"additional","affiliation":[{"name":"School of Business, University of California, Riverside , Riverside , CA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carly S.","family":"Barron","sequence":"additional","affiliation":[{"name":"Department of Pediatrics\/Division of Endocrinology , Weill Cornell Medical College , New York , NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurie E.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics\/Division of Endocrinology , Children\u2019s Hospital at Montefiore , Bronx , NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ala","family":"Ustyol","sequence":"additional","affiliation":[{"name":"Department of Pediatrics\/Division of Endocrinology , Riley Children\u2019s Hospital , Indianapolis , IN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erica A.","family":"Eugster","sequence":"additional","affiliation":[{"name":"Department of Pediatrics\/Division of Endocrinology , Riley Children\u2019s Hospital , Indianapolis , IN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria A.","family":"Fermin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics\/Division of Endocrinology , The University of Texas Health Science Center , Houston , TX , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avni N.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Pediatrics\/Division of Endocrinology , The University of Texas Health Science Center , Houston , TX , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8943-0386","authenticated-orcid":false,"given":"Despoina","family":"Galetaki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics\/Division of Endocrinology , Children\u2019s National Hospital , Washington , DC , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul B.","family":"Kaplowitz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics\/Division of Endocrinology , Children\u2019s National Hospital , Washington , DC , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2025,12,30]]},"reference":[{"key":"2026021914572473330_j_jpem-2025-0395_ref_001","doi-asserted-by":"crossref","unstructured":"Leschek, EW, Rose, SR, Yanovski, JA, Troendle, JF, Quigley, CA, Chipman, JJ, et al.. 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