{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T16:08:49Z","timestamp":1778602129737,"version":"3.51.4"},"reference-count":29,"publisher":"Walter de Gruyter GmbH","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jpem-2025-0407_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Rathke cleft cysts (RCC) in childhood are rare, often asymptomatic, and thus discovered incidentally. We aimed to summarize clinical features and pituitary function of patients with symptomatic\u00a0RCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2025-0407_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included 14 patients (8 male) from the university hospital\u2019s database (period 2005\u20132023).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2025-0407_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>RCC diagnosis based on magnetic resonance imaging at 12.2 (1.8\u201317.6) years. Presenting symptoms were headaches (n=8), occurring alone (n=1) or with nausea\/fatigue (n=2), polydipsia (n=2), or dizziness (n=3), followed by growth retardation (n=5), occurring alone (n=4) or with polydipsia (n=1). Two patients exhibited visual disturbances. Endocrinological evaluation revealed pituitary insufficiency in 10, including isolated or combined growth hormone (GH) deficiency (n=5), arginine-vasopressin deficiency (AVP-D; n=5), central hypothyroidism (n=2), and hypocortisolism (n=2). Three patients had hyperprolactinemia. Nine patients were monitored by regular imaging; five underwent surgery. In the observation group, cyst size remained unchanged in seven and decreased in two patients, while it increased in four patients treated surgically. At last presentation after 6.4 (0.33\u201314.8) years of follow-up, the endocrine status of the conservatively followed patients was normal in n=6, and pathological in n=3. Pituitary function did not normalize after surgery. Five patients developed hypogonadotropic hypogonadism, including two children who were followed conservatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2025-0407_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We found a high incidence of pituitary insufficiency among symptomatic pediatric RCC patients. Pituitary function was not closely related to cyst size or location and did not improve after surgery. Regular clinical and radiological follow-up is mandatory for both conservatively and surgically treated patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jpem-2025-0407","type":"journal-article","created":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T03:58:05Z","timestamp":1760327885000},"page":"1317-1323","source":"Crossref","is-referenced-by-count":0,"title":["The clinical picture of symptomatic Rathke cleft cysts in children"],"prefix":"10.1515","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8129-9056","authenticated-orcid":false,"given":"Ayse Nurcan","family":"Cebeci","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander-University (FAU) , Erlangen-Nuremberg , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela","family":"Marx","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander-University (FAU) , Erlangen-Nuremberg , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina","family":"Trollmann","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander-University (FAU) , Erlangen-Nuremberg , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Buchfelder","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery , University Hospital Erlangen, Friedrich-Alexander-University (FAU) , Erlangen-Nuremberg , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmuth-G\u00fcnther","family":"D\u00f6rr","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander-University (FAU) , Erlangen-Nuremberg , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Woelfle","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander-University (FAU) , Erlangen-Nuremberg , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2025,10,13]]},"reference":[{"key":"2026051215122186768_j_jpem-2025-0407_ref_001","doi-asserted-by":"crossref","unstructured":"Teramoto, A, Hirakawa, K, Sanno, N, Osamura, Y. 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