{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T09:51:21Z","timestamp":1782121881419,"version":"3.54.5"},"reference-count":6,"publisher":"Walter de Gruyter GmbH","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"Abstract<\/jats:title>\n \n Objectives<\/jats:title>\n To determine the incidence and severity of thyroid dysfunction following iodinated contrast media (ICM) exposure in our pediatric heart center, assess adherence to FDA guidelines and evaluate the utility of routine thyroid function testing.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This retrospective study reviewed charts of 186 patients under four years old who underwent cardiac catheterization between June 2022 and June 2024 at our pediatric heart center. Data collected included age, sex, gestational age, ethnicity, ICM use, and post-procedure thyroid-stimulating hormone (TSH) levels. Additional risk factors were assessed for patients with abnormal thyroid studies.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Of the 186 cardiac catheterization procedures, 155 involved administration of ICM. Follow-up thyroid studies were conducted after 113 of these; three lab draws were excluded due to new diagnoses of hypothyroidism made during the study period. Among the remaining 110 cases with indicated TSH testing, only two patients (1.8\u202f%) demonstrated persistently elevated TSH levels\u00a0\u2013\u00a0both of whom had pre-existing risk factors for thyroid dysfunction. Among the 113 cases that completed follow-up TSH studies, 69 (61.1\u202f%) occurred within the FDA\u2019s recommended 3-week period. Post-procedure thyroid studies were not completed in 42 cases (27.1\u202f%), although four patients had passed away and four were transferred to another hospital system.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n No clinically significant relationship was found between ICM exposure and thyroid dysfunction in patients under four years old, suggesting routine post-catheterization thyroid screening may be unnecessary.<\/jats:p>\n <\/jats:sec>","DOI":"10.1515\/jpem-2026-0036","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T08:00:34Z","timestamp":1782115234000},"source":"Crossref","is-referenced-by-count":0,"title":["Investigating thyroid dysfunction in pediatric patients following the administration of iodinated contrast media during cardiac catheterization"],"prefix":"10.1515","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9173-4960","authenticated-orcid":false,"given":"William Wyatt","family":"Lindsey","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences , Alabama College of Osteopathic Medicine , Dothan , AL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0232-9316","authenticated-orcid":false,"given":"Alycia P.","family":"Heiner","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology , Inova L.J.\u00a0Murphy Children\u2019s Hospital , Falls Church , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen E.","family":"Barbieri","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology , Inova L.J.\u00a0Murphy Children\u2019s Hospital , Falls Church , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine E.","family":"Tomasulo","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology , Inova L.J.\u00a0Murphy Children\u2019s Hospital , Falls Church , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"2026062209242494452_j_jpem-2026-0036_ref_001","doi-asserted-by":"crossref","unstructured":"Koeppel, DR, Boehm, IB. Shortage of iodinated contrast media: status and possible chances\u00a0\u2013\u00a0a systematic review. Eur J Radiol 2023;164:110853. https:\/\/doi.org\/10.1016\/j.ejrad.2023.110853.","DOI":"10.1016\/j.ejrad.2023.110853"},{"key":"2026062209242494452_j_jpem-2026-0036_ref_002","doi-asserted-by":"crossref","unstructured":"Davenport, MS, Chu, P, Szczykutowicz, TP, Smith-Bindman, R. Comparison of strategies to conserve iodinated intravascular contrast media for computed tomography during a shortage. JAMA 2022;328:476\u20138. https:\/\/doi.org\/10.1001\/jama.2022.9879.","DOI":"10.1001\/jama.2022.9879"},{"key":"2026062209242494452_j_jpem-2026-0036_ref_003","unstructured":"\u201cFDA recommends thyroid monitoring in babies and young children who receive injections of iodine-containing contrast media for medical imaging.\u201d U.S. Food and Drug Administration, 2022. Available from: https:\/\/www.fda.gov\/drugs\/drug-safety-and-availability\/fda-recommends-thyroid-monitoring-babies-and-young-children-who-receive-injections-iodine-containing."},{"key":"2026062209242494452_j_jpem-2026-0036_ref_004","doi-asserted-by":"crossref","unstructured":"Kaluarachchi, DC, Colaizy, TT, Pesce, LM, Tansey, M, Klein, JM. Congenital hypothyroidism with delayed thyroid-stimulating hormone elevation in premature infants born at less than 30\u00a0weeks gestation. J\u00a0Perinatol Off J Calif Perinat Assoc 2017;37:277\u201382. https:\/\/doi.org\/10.1038\/jp.2016.213.","DOI":"10.1038\/jp.2016.213"},{"key":"2026062209242494452_j_jpem-2026-0036_ref_005","doi-asserted-by":"crossref","unstructured":"Bull, MJ. Committee on Genetics. Health supervision for children with Down syndrome. Pediatrics 2011;128:393\u2013406. https:\/\/doi.org\/10.1542\/peds.2011-1605.","DOI":"10.1542\/peds.2011-1605"},{"key":"2026062209242494452_j_jpem-2026-0036_ref_006","doi-asserted-by":"crossref","unstructured":"Wyne, KL, Nair, L, Schneiderman, CP, Pinsky, B, Antunez Flores, O, Guo, D, et al.. Hypothyroidism prevalence in the United\u00a0States: a retrospective study combining National Health and Nutrition Examination Survey and claims data, 2009\u20132019. J\u00a0Endocr Soc 2022;7:bvac172. https:\/\/doi.org\/10.1210\/jendso\/bvac172.","DOI":"10.1210\/jendso\/bvac172"}],"container-title":["Journal of Pediatric Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jpem-2026-0036\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jpem-2026-0036\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T09:24:45Z","timestamp":1782120285000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jpem-2026-0036\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,23]]},"references-count":6,"alternative-id":["10.1515\/jpem-2026-0036"],"URL":"https:\/\/doi.org\/10.1515\/jpem-2026-0036","relation":{},"ISSN":["0334-018X","2191-0251"],"issn-type":[{"value":"0334-018X","type":"print"},{"value":"2191-0251","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,23]]}}}