{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:51:05Z","timestamp":1791478265854,"version":"4.3.4"},"reference-count":28,"publisher":"Walter de Gruyter GmbH","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jpem-2026-0042_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The prevalence of type 1 diabetes mellitus (T1DM) has increased along with rising incidence of childhood obesity. This study aims to investigate the prevalence of islet-related autoantibodies among obese children in China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2026-0042_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study enrolled patients with moderate to severe obesity aged under 18\u00a0years who were admitted between 1 January 2019 and 30 April 2024. Glutamic acid decarboxylase antibody, insulin autoantibody, islet cell autoantibody, zinc transporter 8 autoantibody, and insulinoma-associated protein 2 autoantibody, were measured through chemiluminescent immunoassay. A comparative analysis was conducted of the indicators for glycemic metabolism among the three subgroups, defined according to their autoantibody status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2026-0042_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 1,826 obese children included, 10.9\u202f% were positive for at least one autoantibody, significantly higher than the normal-weight population (1.86\u202f%, p&lt;0.001). Positive results for two autoantibodies were observed in 1.9\u202f% of obese children, statistically higher than in the general population (0.39\u202f%, p&lt;0.01). The HbA\n                      <jats:sub>1c<\/jats:sub>\n                      level of the two antibody positive groups was statistically higher than that of the antibody negative group (5.8\u202f% vs. 5.6\u202f%, p=0.012). No statistical difference was observed among the three groups regarding anthropometric indicators, biochemical parameters and indicators of glucose metabolism.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2026-0042_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The prevalence of islet-related autoantibodies is higher in obese children, which may contribute to an increasing susceptibility to T1DM. The study underscores the necessity for screening in obese children, as this may facilitate early intervention for\u00a0T1DM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jpem-2026-0042","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T08:57:25Z","timestamp":1787216245000},"page":"1017-1022","source":"Crossref","is-referenced-by-count":0,"title":["Higher prevalence of islet-related autoantibody positivity in obese Chinese children and adolescents"],"prefix":"10.1515","volume":"39","author":[{"given":"Li","family":"Yujie","sequence":"first","affiliation":[{"name":"Department of Endocrinology , Children\u2019s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children\u2019s Regional Medical Center , Hangzhou , Zhejiang Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yangxi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology , Children\u2019s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children\u2019s Regional Medical Center , Hangzhou , Zhejiang Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Congyue","sequence":"additional","affiliation":[{"name":"Department of Endocrinology , Children\u2019s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children\u2019s Regional Medical Center , Hangzhou , Zhejiang Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Jinling","sequence":"additional","affiliation":[{"name":"Department of Endocrinology , Children\u2019s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children\u2019s Regional Medical Center , Hangzhou , Zhejiang Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huang","family":"Ke","sequence":"additional","affiliation":[{"name":"Department of Endocrinology , Children\u2019s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children\u2019s Regional Medical Center , Hangzhou , Zhejiang Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Endocrinology , Children\u2019s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children\u2019s Regional Medical Center , Hangzhou , Zhejiang Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Guanping","sequence":"additional","affiliation":[{"name":"Department of Endocrinology , Children\u2019s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children\u2019s Regional Medical Center , Hangzhou , Zhejiang Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"2026100815572192639_j_jpem-2026-0042_ref_001","doi-asserted-by":"crossref","unstructured":"Waldh\u00f6r, T, Schober, E, Rami, B. 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