{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T17:50:09Z","timestamp":1791481809677,"version":"4.3.4"},"reference-count":30,"publisher":"Walter de Gruyter GmbH","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jpem-2026-0121_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Children with multiple food allergies (MFA) often follow elimination diets that restrict major dietary sources of iodine, thereby increasing the risk of iodine deficiency. This study aimed to evaluate urinary iodine concentration (UIC) and thyroid function parameters in children with MFA and to compare these findings with those of age- and sex-matched healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2026-0121_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective cross-sectional study, 47 children aged 0\u201313\u00a0years with IgE-mediated MFA on elimination diets were compared with 52 age- and sex-matched healthy controls between October 2022 and March 2024. Serum thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxine (fT4) were measured using electrochemiluminescence immunoassay, and UIC was determined by inductively coupled plasma mass spectrometry (ICP-MS). Anthropometric parameters were also assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2026-0121_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Serum TSH, fT3, and fT4 levels did not differ significantly between the MFA and control groups (p&gt;0.05). However, median UIC was significantly lower in the MFA group [86\u202f\u03bcg\/L (IQR: 50\u2013115)] compared with controls [126\u202f\u03bcg\/L (IQR: 105\u2013134)] (p=0.001), indicating mild iodine deficiency in the MFA group. No cases of overt hypothyroidism were detected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2026-0121_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Children with multiple food allergies receiving elimination diets are at increased risk of mild iodine deficiency, even in iodine-sufficient regions, although overt thyroid dysfunction may not yet be evident. These findings highlight the importance of routine monitoring of iodine status and early nutritional interventions in this vulnerable population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jpem-2026-0121","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T08:55:37Z","timestamp":1784883337000},"page":"883-890","source":"Crossref","is-referenced-by-count":0,"title":["Iodine status and thyroid function in children with multiple food allergy: a prospective cross-sectional study"],"prefix":"10.1515","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2867-3851","authenticated-orcid":false,"given":"Suat","family":"Tekin","sequence":"first","affiliation":[{"name":"Pediatric Endocrinology , Van Training and Research Hospital, University of Health Science , Van , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7733-9067","authenticated-orcid":false,"given":"Serkan","family":"Filiz","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunulogy , Antalya Training and Research Hospital, University of Health Science , Antalya , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1014-5831","authenticated-orcid":false,"given":"Merve","family":"Gullu","sequence":"additional","affiliation":[{"name":"Sancaktepe \u015eehit Prof.Dr. \u0130lhan Varank E\u011fitim ve Ara\u015ft\u0131rma Hastanesi , Istanbul , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2413-2695","authenticated-orcid":false,"given":"Guzin","family":"Aykal","sequence":"additional","affiliation":[{"name":"Antalya Training and Research, Biochemistry, University of Health Science , Antalya , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3776-9975","authenticated-orcid":false,"given":"R\u0131za Taner","family":"Baran","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology , Antalya Training and Research Hospital, University of Health Science , Antalya , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"2026100816572541931_j_jpem-2026-0121_ref_001","doi-asserted-by":"crossref","unstructured":"Zimmermann, MB. Iodine deficiency. Endocr Rev 2009;30:376\u2013408. https:\/\/doi.org\/10.1210\/er.2009-0011.","DOI":"10.1210\/er.2009-0011"},{"key":"2026100816572541931_j_jpem-2026-0121_ref_002","doi-asserted-by":"crossref","unstructured":"Andersson, M, Karumbunathan, V, Zimmermann, MB. Global iodine status in 2011 and trends over the past decade. J\u00a0Nutr 2012;142:744\u201350. https:\/\/doi.org\/10.3945\/jn.111.149393.","DOI":"10.3945\/jn.111.149393"},{"key":"2026100816572541931_j_jpem-2026-0121_ref_003","unstructured":"World Health Organization. United nations children\u2019s fund, international council for the control of iodine deficiency Disorders. In: Assessment of iodine deficiency disorders and monitoring their elimination, 3rd ed.. Geneva: World Health Organization; 2007:5\u20136 pp."},{"key":"2026100816572541931_j_jpem-2026-0121_ref_004","doi-asserted-by":"crossref","unstructured":"Zimmermann, MB, Connolly, K, Bozo, M, Bridson, J, Rohner, F, Grimci, L. 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