{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T05:52:07Z","timestamp":1781502727722,"version":"3.54.1"},"reference-count":14,"publisher":"Walter de Gruyter GmbH","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"Abstract<\/jats:title>\n \n Objectives<\/jats:title>\n Mucopolysaccharidoses (MPS) are disease characterized by the accumulation of glycosaminoglycans, which leads to involvement of multiple systems. Respiratory involvement can lead to obstructions, causing difficulties with daily vital functions and sleep problems. This study aims to assess the sleep quality and disorders of patients with MPS using questionnaires.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n The study comprised 24 patients diagnosed with MPS and 44 healthy children aged between 6 and 18\u00a0years. Patients\u2019 age, gender, height, weight, MPS subtype, age at diagnosis, enzyme replacement therapy status, and respiratory system findings (recurrent infections, snoring, adenotonsillar hypertrophy) were recorded. The Sleep Disturbance Scale for Children (SDSC) and the Pittsburgh Sleep Quality Index (PSQI) questionnaires were administered to both groups in order to assess sleep quality and disorders.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n According to the SDSC, sleep onset and maintenance disorders, sleep breathing disorders, sleep-wake transition disorders, excessive sleepiness disorders, sleep hyperhidrosis, and the total SDSC scores were higher in the patient group. According to the PSQI, sleep quality, sleep disturbance, daytime dysfunction, and the total PSQI scores were higher in the patient group. No significant differences were found in SDSC and PSQI total scores according to MPS subtypes.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Sleep problems are frequently unnoticed, yet they can have a considerable impact on the quality of life of patients with MPS. In this context, the SDSC and PSQI questionnaires can be utilized to swiftly and cost-effectively screen for sleep problems in patients with MPS. This facilitates the timely identification of sleep disorders, thus enabling the implementation of appropriate preventative measures.<\/jats:p>\n <\/jats:sec>","DOI":"10.1515\/jpem-2026-0186","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T04:55:50Z","timestamp":1781499350000},"source":"Crossref","is-referenced-by-count":0,"title":["The silent threat in mucopolysaccharidosis: assessment of sleep quality and disorders"],"prefix":"10.1515","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2036-4082","authenticated-orcid":false,"given":"Nafiye Emel","family":"\u00c7akar","sequence":"first","affiliation":[{"name":"Department of Pediatric Metabolism , University of Health Sciences, Prof. Dr. Cemil Ta\u015fc\u0131o\u011flu City Hospital , Istanbul , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimet P\u0131nar","family":"Y\u0131lmazba\u015f","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , University of Health Sciences, Prof. Dr. Cemil Ta\u015fc\u0131o\u011flu City Hospital , Istanbul , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meryem","family":"Karaca","sequence":"additional","affiliation":[{"name":"Department of Pediatric Metabolism , Istanbul University Faculty of Medicine , Istanbul , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asl\u0131","family":"Durmu\u015f","sequence":"additional","affiliation":[{"name":"Department of Pediatric Metabolism , Trabzon Kanuni Sultan S\u00fcleyman Training and Research Hospital , Trabzon , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7264-038X","authenticated-orcid":false,"given":"Arzu","family":"Selamio\u011flu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Metabolism , Ba\u011fc\u0131lar Training and Research Hospital , Istanbul , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00fcseyin Kutay","family":"K\u00f6rbeyli","sequence":"additional","affiliation":[{"name":"Department of Pediatric Metabolism , Kanuni Sultan S\u00fcleyman Training and Research Hospital , Istanbul , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seda","family":"G\u00fcne\u015f","sequence":"additional","affiliation":[{"name":"Department of Pediatric Metabolism , Harran University Faculty of Medicine , \u015eanl\u0131urfa , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamze","family":"Karamanl\u0131","sequence":"additional","affiliation":[{"name":"Department of Pediatric Metabolism , University of Health Sciences, Prof. Dr. Cemil Ta\u015fc\u0131o\u011flu City Hospital , Istanbul , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melda Fatma","family":"\u0130driso\u011flu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Metabolism , University of Health Sciences, Prof. Dr. Cemil Ta\u015fc\u0131o\u011flu City Hospital , Istanbul , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fclden Fatma","family":"G\u00f6k\u00e7ay","sequence":"additional","affiliation":[{"name":"Department of Pediatric Metabolism , Istanbul University Faculty of Medicine , Istanbul , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"2026061504554739663_j_jpem-2026-0186_ref_001","doi-asserted-by":"crossref","unstructured":"Howie, AH, Tingley, K, Inbar-Feigenberg, M, Mitchell, JJ, Angel, K, Gentle, J, et al.. 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