{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:47:30Z","timestamp":1791978450538,"version":"4.4.0"},"reference-count":26,"publisher":"Walter de Gruyter GmbH","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jpem-2026-0270_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Maternal hypertensive disorders of pregnancy (HDP) increase the risk of meconium obstruction of prematurity in small-for-gestational-age (SGA) extremely low birth weight (ELBW) infants. While prophylactic intragastric amidotrizoate (Gastrografin\n                      <jats:sup>\u00ae<\/jats:sup>\n                      ) promotes meconium excretion, concerns persist regarding iodine load and thyroid dysfunction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2026-0270_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed infants (&lt;30\u00a0weeks, &lt;700\u202fg) born 2016\u20132024. The treated group (n=20) comprised SGA infants of mothers with HDP receiving prophylactic 5-fold diluted Gastrografin (iodine: 148\u2013222\u202fmg\/kg) after stabilization. Controls included nontreated SGA infants (n=17), mostly lacking maternal HDP (thus not meeting prophylaxis criteria), and an appropriate-for-gestational-age (AGA) reference cohort (n=48). A 2018\u20132022 unexposed subcohort (n=21) provided baseline urinary iodine concentration (UIC)\u00a0data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2026-0270_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Treatment failure, necessitating therapeutic enema, occurred in 1\/20 treated infants (5\u202f%). Baseline UIC was 32 (IQR 25\u2013127) vs. 25 (IQR 25\u201335) \u00b5g\/L in combined controls (p=0.23). Day 1 postadministration, UIC surged to 326,000 (IQR 201,500\u2013455,350) \u00b5g\/L; by 2\u00a0weeks, it normalized to 348 vs. 267\u202f\u03bcg\/L (p=0.51). At 2\u00a0weeks, thyroid function was comparable between treated and nontreated SGA groups for TSH (5.8 vs. 5.1\u202f\u03bcIU\/mL; p=0.94), free T3 (1.56 vs. 1.55\u202fpg\/mL; p=0.68), and free T4 (0.98 vs. 0.78\u202fng\/dL; p=0.31), though baseline HDP differences necessitate careful interpretation. Levothyroxine supplementation rates were 26\u202f% vs. 13\u202f%, respectively (p=0.42).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2026-0270_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Early postnatal iodine levels in preterm infants are low. Prophylactic intragastric Gastrografin facilitated meconium evacuation in high-risk SGA ELBW infants. The associated iodine elevation is transient. A nonsignificant numerical increase in levothyroxine supplementation within our small cohort necessitates further large-scale studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jpem-2026-0270","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:55:51Z","timestamp":1791975351000},"source":"Crossref","is-referenced-by-count":0,"title":["Iodine exposure and thyroid function after prophylactic intragastric iodinated contrast administration for meconium obstruction of prematurity in extremely low birth weight infants"],"prefix":"10.1515","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8490-475X","authenticated-orcid":false,"given":"Tomoyuki","family":"Shimokaze","sequence":"first","affiliation":[{"name":"Department of Neonatology , Kanagawa Children\u2019s Medical Center , Yokohama , Kanagawa , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuaki","family":"Toyoshima","sequence":"additional","affiliation":[{"name":"Department of Neonatology , Kanagawa Children\u2019s Medical Center , Yokohama , Kanagawa , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Hawaka","sequence":"additional","affiliation":[{"name":"Department of Neonatology , Kanagawa Children\u2019s Medical Center , Yokohama , Kanagawa , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Department of Neonatology , Kanagawa Children\u2019s Medical Center , Yokohama , Kanagawa , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Neonatology , Kanagawa Children\u2019s Medical Center , Yokohama , Kanagawa , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Shibasaki","sequence":"additional","affiliation":[{"name":"Department of Neonatology , Kanagawa Children\u2019s Medical Center , Yokohama , Kanagawa , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Hanakawa","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism , Kanagawa Children\u2019s Medical Center , Yokohama , Kanagawa , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Muroya","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism , Kanagawa Children\u2019s Medical Center , Yokohama , Kanagawa , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"key":"2026101410554784877_j_jpem-2026-0270_ref_001","doi-asserted-by":"crossref","unstructured":"Arnoldi, R, Leva, E, Macchini, F, Di Cesare, A, Colnaghi, M, Fumagalli, M, et al.. 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