{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:50:52Z","timestamp":1791391852305,"version":"4.3.3"},"reference-count":31,"publisher":"Walter de Gruyter GmbH","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jpem-2026-0544_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate long-term thyroid outcomes and thiol\u2013disulfide homeostasis (TDH) in childhood Hodgkin lymphoma (HL) survivors treated with neck radiotherapy\u00a0(RT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2026-0544_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty consecutive childhood HL survivors and 40 healthy controls were included. Thyroid function, autoimmunity markers, and ultrasonographic findings were evaluated in survivors. Native thiol, total thiol, disulfide, and related ratios were assessed in both groups. Factors associated with subclinical hypothyroidism and thyroid nodules were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2026-0544_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Survivors had a median age of 16.8\u00a0years (range, 5.1\u201333.2) and a median interval since RT of 4.6\u00a0years (range, 1.3\u201320.2). Seventeen survivors (42.5\u202f%) had received &gt;25\u202fGy neck RT. Subclinical hypothyroidism was identified in 18 survivors (45.0\u202f%); 13 of these 18 (72.2\u202f%) were receiving levothyroxine. Thyroid nodules were identified in seven survivors (17.5\u202f%), with no thyroid malignancy detected. TDH parameters did not differ significantly between survivors and controls. In survivors, native thiol\/total thiol and disulfide\/total thiol ratios correlated significantly with free T4 and free T3 concentrations. Thyroid nodule presence was associated with longer time since RT (OR=1.354 per year).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpem-2026-0544_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Functional and structural thyroid abnormalities were frequent in childhood HL survivors treated with neck RT, supporting continued thyroid surveillance. Associations between TDH ratios and thyroid hormones in survivors remain exploratory and warrant evaluation in longitudinal studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jpem-2026-0544","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:55:58Z","timestamp":1791388558000},"source":"Crossref","is-referenced-by-count":0,"title":["Long-term thyroid outcomes and thiol\u2013disulfide homeostasis in childhood Hodgkin lymphoma survivors treated with neck radiotherapy"],"prefix":"10.1515","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5468-9304","authenticated-orcid":false,"given":"Mustafa Safa","family":"Kas\u0131m","sequence":"first","affiliation":[{"name":"Department of Pediatrics , University of Health Sciences, Sisli Hamidiye Etfal Research and Training Hospital , Istanbul , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5237-8377","authenticated-orcid":false,"given":"Dildar Bahar","family":"Gen\u00e7","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology , University of Health Sciences, Sisli Hamidiye Etfal Research and Training Hospital , Istanbul , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7479-7444","authenticated-orcid":false,"given":"S\u00fcheyla","family":"Ocak","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology , Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa , Istanbul , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0315-5625","authenticated-orcid":false,"given":"\u015eevval Kaplan","family":"K\u0131l\u0131\u00e7","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa , Istanbul , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1027-2598","authenticated-orcid":false,"given":"Halil \u0130brahim","family":"Ada","sequence":"additional","affiliation":[{"name":"Department of Radiology , University of Health Sciences, Sisli Hamidiye Etfal Research and Training Hospital , Istanbul , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0974-5717","authenticated-orcid":false,"given":"Salim","family":"Ne\u015felio\u011flu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry , Ankara Bilkent City Hospital , Ankara , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8649-2493","authenticated-orcid":false,"given":"Funda","family":"Eren","sequence":"additional","affiliation":[{"name":"Department of Biochemistry , Ankara Bilkent City Hospital , Ankara , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1615-1164","authenticated-orcid":false,"given":"Hediye \u00c7i\u011fdem","family":"\u015eim\u015fek","sequence":"additional","affiliation":[{"name":"Department of Biochemistry , Kanuni Sultan Suleiman Training and Research Hospital , Istanbul , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8144-8437","authenticated-orcid":false,"given":"Ahmet","family":"U\u00e7ar","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology , University of Health Sciences, Sisli Hamidiye Etfal Research and Training Hospital , Istanbul , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"key":"2026100715554977505_j_jpem-2026-0544_ref_001","doi-asserted-by":"crossref","unstructured":"Ward, E, DeSantis, C, Robbins, A, Kohler, B, Jemal, A. 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