{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:32:45Z","timestamp":1791167565201,"version":"4.1.0"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Aims:<\/jats:bold>\n                    The aim of this study was to investigate the current prenatal \u201coff-label use\u201d of cytomegalovirus hyperimmunoglobulin (CMV-HIG) in the prevention and treatment of congenital CMV (cCMV) infection, including the long-term outcome of the children.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    This retrospective observational study comprised mothers and their children, born between January 1, 2006, and October 30, 2010. Prenatal CMV-HIG was administered after diagnosis of primary CMV infection of the mother. Clinical and virological data were collected from maternal and pediatric medical and laboratory reports. Follow-up was 12\u201336 months after birth.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Forty-two women and 43 children met the study criteria. In total, 40 mothers and six unborn infants received 115 doses of CMV-HIG. The treatment group (TG; CMV-DNA polymerase chain reaction-positive amniotic fluid) included four mothers; the multinomial group (MG; CMV-positive mother and unknown CMV status of fetus) included 38 mothers (39 infants). For the four unborn infants in TG, CMV-HIG was administered either intraumbilically or into the amniotic fluid; three of the four mothers received intravenous CMV-HIG. Three children in TG remained CMV-positive and were asymptomatic at birth and during follow-up. One infant in TG had symptomatic cCMV infection\n                    <jats:italic>in utero<\/jats:italic>\n                    , at birth, and during follow-up. In MG, 37 of 38 women received intravenous CMV-HIG and two of 39 infants received CMV-HIG\n                    <jats:italic>in utero<\/jats:italic>\n                    . In total, 9 (23.1%) of 39 children in MG were positive for cCMV (including a terminated pregnancy). All eight instances of cCMV infection at birth in MG were asymptomatic at birth and during follow-up. The fetus from the terminated pregnancy showed no sonographic symptoms of cCMV infection. No severe side effect occurred in 115 CMV-HIG applications.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    CMV-HIG was well tolerated. Compared with published untreated mother-child pairs, we observed a trend toward a smaller risk for intrauterine CMV transmission following CMV-HIG application. Signs of prenatal cCMV disease were not reversed after CMV-HIG.\n                  <\/jats:p>","DOI":"10.1515\/jpm-2011-0257","type":"journal-article","created":{"date-parts":[[2012,6,8]],"date-time":"2012-06-08T11:27:34Z","timestamp":1339154854000},"page":"439-446","source":"Crossref","is-referenced-by-count":90,"title":["Use of cytomegalovirus hyperimmunoglobulin for prevention of congenital cytomegalovirus disease: a retrospective analysis"],"prefix":"10.1515","volume":"40","author":[{"given":"Horst","family":"Buxmann","sequence":"first","affiliation":[{"name":"Department of Neonatology, University Hospital, Johann Wolfgang Goethe University, Frankfurt\/Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otto M.v.","family":"Stackelberg","sequence":"additional","affiliation":[{"name":"Department of Neonatology, University Hospital, Johann Wolfgang Goethe University, Frankfurt\/Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf L.","family":"Schl\u00f6\u00dfer","sequence":"additional","affiliation":[{"name":"Department of Neonatology, University Hospital, Johann Wolfgang Goethe University, Frankfurt\/Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisela","family":"Enders","sequence":"additional","affiliation":[{"name":"Laboratory Prof. G. Enders and Partner and Institute of Virology, Infectious Diseases and Epidemiology e.V., Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Gonser","sequence":"additional","affiliation":[{"name":"Clinic of Obstetrics and Prenatal Medicine, Dr. Horst Schmidt Clinic, Wiesbaden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Meyer-Wittkopf","sequence":"additional","affiliation":[{"name":"Department of Prenatal Diagnosis, Mathias Hospital, Rheine, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Hamprecht","sequence":"additional","affiliation":[{"name":"Institute of Medical Virology and Epidemiology of Viral Disease, University Hospital, Eberhard-Karls University, Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Enders","sequence":"additional","affiliation":[{"name":"Laboratory Prof. G. Enders and Partner and Institute of Virology, Infectious Diseases and Epidemiology e.V., Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2012,3,27]]},"container-title":["Journal of Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2011-0257\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2011-0257\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T23:21:03Z","timestamp":1678749663000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2011-0257\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,27]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2012,2,14]]},"published-print":{"date-parts":[[2012,6,1]]}},"alternative-id":["10.1515\/jpm-2011-0257"],"URL":"https:\/\/doi.org\/10.1515\/jpm-2011-0257","relation":{},"ISSN":["1619-3997","0300-5577"],"issn-type":[{"value":"1619-3997","type":"electronic"},{"value":"0300-5577","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3,27]]}}}