{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,7,16]],"date-time":"2023-07-16T11:31:11Z","timestamp":1689507071015},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Perinatal Medicine"],"published-print":{"date-parts":[[2013,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>\n                  <jats:bold>Background:<\/jats:bold> Oxygen supplementation is still part of international resuscitation protocols for premature children. Mechanisms for tissue damage by hypoxia\/ischemia in the extreme premature involve inflammation.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Aim and method:<\/jats:bold> To study cerebral inflammation after hypoxia\/ischemia and oxygen treatment in the premature, we measured NF-\u03baB activity in 5-day-old transgenic reporter mice in response to experimental hypoxia\/ischemia. Results were correlated to cerebral histological evaluation and plasma cytokine levels. A treatment strategy with the antioxidant tempol was tested.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> One day after hypoxia\/ischemia NF-\u03baB activation was increased compared to controls [mean difference: 10.6\u00b14.6% (P=0.03)]. Exposure to 100% oxygen after hypoxia\/ischemia further increased NF-\u03baB activation compared to hypoxia\/ischemia alone [mean difference: 15.0\u00b15.5% (P=0.01)]. Histological changes in the brain were positively correlated with NF-\u03baB activity (P&lt;0.001), but we found no significant difference in tissue damage between resuscitation with air and resuscitation with pure oxygen. Administration of tempol reduced NF-\u03baB activation [mean difference: 14.6\u00b15.0% (P=0.01)] and the plasma level of cytokines; however, the histological damage score was not affected.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion:<\/jats:bold> Cerebral inflammatory response after hypoxia\/ischemia in a mouse model with immature brain development corresponding to human prematurity prior to 32 weeks\u2019 gestation was influenced by administration of oxygen. Tempol treatment attenuated inflammation but did not reduce the extent of histological cerebral damage.<\/jats:p>","DOI":"10.1515\/jpm-2012-0135","type":"journal-article","created":{"date-parts":[[2012,12,14]],"date-time":"2012-12-14T22:00:29Z","timestamp":1355522429000},"page":"251-257","source":"Crossref","is-referenced-by-count":3,"title":["Hyperoxic resuscitation after hypoxia-ischemia induces cerebral inflammation that is attenuated by tempol in a reporter mouse model with very young mice"],"prefix":"10.1515","volume":"41","author":[{"given":"Gaute","family":"D\u00f8hlen","sequence":"first","affiliation":[{"name":"Department of Paediatric Research, University of Oslo and Oslo University Hospital, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen-Ann","family":"Antal","sequence":"additional","affiliation":[{"name":"Department of Pathology, Oslo University Hospital, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Castellheim","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Oslo University Hospital, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Thaulow","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology, Oslo University Hospital, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Kielland","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ola Didrik","family":"Saugstad","sequence":"additional","affiliation":[{"name":"Department of Paediatric Research, University of Oslo and Oslo University Hospital, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2012,11,15]]},"container-title":["jpme"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2012-0135\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2012-0135\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T03:21:59Z","timestamp":1678764119000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2012-0135\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,15]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,12,3]]},"published-print":{"date-parts":[[2013,5,1]]}},"alternative-id":["10.1515\/jpm-2012-0135"],"URL":"https:\/\/doi.org\/10.1515\/jpm-2012-0135","relation":{},"ISSN":["1619-3997","0300-5577"],"issn-type":[{"value":"1619-3997","type":"electronic"},{"value":"0300-5577","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11,15]]}}}