{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T03:40:53Z","timestamp":1678765253426},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Perinatal Medicine"],"published-print":{"date-parts":[[2013,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>\n                  <jats:bold>Aims<\/jats:bold>: The study set out to investigate whether the osteopontin (OPN)-CD44-integrin-receptor-system is differently regulated during nephrogenesis in inborn nephron deficit, a major determinant of human primary hypertension and cardiovascular disease in adult life.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methods<\/jats:bold>: We compared a genetic rat model with an inherited nephron deficit, the Munich-Wistar-Froemter rat (MWF), to normotensive Wistar rats during nephrogenesis at day 19 of fetal development (E19) and at postpartal day 7 (D7).<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results<\/jats:bold>: Renal OPN mRNA (\u201375%, P&lt;0.05) and protein expression (\u201338%, P&lt;0.05) were strongly decreased at E19 in MWF compared to Wistar. Renal mRNA-expression of CD44 was increased at E19 in MWF (+271%, P&lt;0.05). At D7, renal OPN protein expression was increased (+115%, P&lt;0.05) and renal mRNA-expression of CD44 remained elevated compared to Wistar control (+127%, P&lt;0.05).<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusions<\/jats:bold>: Altered fetal expression of the OPN-CD44-integrin-receptor-system in the MWF model points to a possible role in low nephron number hypertension and cardiovascular disease.<\/jats:p>","DOI":"10.1515\/jpm-2012-0178","type":"journal-article","created":{"date-parts":[[2012,12,14]],"date-time":"2012-12-14T22:02:42Z","timestamp":1355522562000},"page":"295-299","source":"Crossref","is-referenced-by-count":1,"title":["Genetic low nephron number hypertension is associated with altered expression of osteopontin and CD44 during nephrogenesis*"],"prefix":"10.1515","volume":"41","author":[{"given":"Anne","family":"Freese","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Wehland","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Klinische Pharmakologie und Toxikologie, Campus Benjamin Franklin, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Freese","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Klinische Pharmakologie und Toxikologie, Campus Benjamin Franklin, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Bamberg","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Frauenheilkunde und Geburtshilfe, Campus Virchow-Klinikum, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhold","family":"Kreutz","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Klinische Pharmakologie und Toxikologie, Campus Benjamin Franklin, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Rothermund","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Klinische Pharmakologie und Toxikologie, Campus Benjamin Franklin, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2012,12,15]]},"container-title":["jpme"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2012-0178\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2012-0178\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T03:22:01Z","timestamp":1678764121000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2012-0178\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,15]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,12,3]]},"published-print":{"date-parts":[[2013,5,1]]}},"alternative-id":["10.1515\/jpm-2012-0178"],"URL":"https:\/\/doi.org\/10.1515\/jpm-2012-0178","relation":{},"ISSN":["1619-3997","0300-5577"],"issn-type":[{"value":"1619-3997","type":"electronic"},{"value":"0300-5577","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12,15]]}}}