{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T09:34:18Z","timestamp":1783071258252,"version":"3.54.6"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Perinatal Medicine"],"published-print":{"date-parts":[[2013,5,1]]},"abstract":"Abstract<\/jats:title>\n \n Aim:<\/jats:bold> The aim of this study was to compare the performance of tests based on the detection of insulin-like growth factor binding protein 1 (IGFBP-1) and placental \u03b1-microglobulin-1 (PAMG-1) in diagnosing rupture of fetal membranes (ROM) across different patient populations.<\/jats:p>\n \n Methods:<\/jats:bold> A meta-analysis was conducted on prospective observational or cohort studies investigating ROM tests based on the detection of IGFBP-1 and PAMG-1 meeting the following criteria: (1) performance metrics calculated by comparing results to an adequate reference method; (2) sensitivity thresholds of the investigated tests matching those of the currently available tests; (3) study population, as a minimum, included patients between 25 and 37 weeks of gestation. Sensitivities, specificities, and diagnostic odds ratios were calculated.<\/jats:p>\n \n Results:<\/jats:bold> Across all patient populations, the analyzed performance measures of the PAMG-1 test were significantly superior compared with those of the IGFBP-1 test. Of particular clinical relevance, PAMG-1 outperformed IGFBP-1 in the equivocal group, which comprised patients with uncertain rupture of membranes (sensitivity, 96.0% vs. 73.9%; specificity, 98.9% vs. 77.8%; PAMG-1 vs. IGFBP-1 tests, respectively).<\/jats:p>\n \n Conclusions:<\/jats:bold> Compared with its performance in women with known membrane status, the accuracy of the IGFBP-1 test decreases significantly when used on patients whose membrane status is unknown. In this latter clinically relevant population, the PAMG-1 test has higher accuracy than the IGFBP-1 test.<\/jats:p>","DOI":"10.1515\/jpm-2012-0247","type":"journal-article","created":{"date-parts":[[2013,1,10]],"date-time":"2013-01-10T21:23:04Z","timestamp":1357852984000},"page":"233-240","source":"Crossref","is-referenced-by-count":34,"title":["The diagnosis of rupture of fetal membranes (ROM): a meta-analysis"],"prefix":"10.1515","volume":"41","author":[{"given":"Babett","family":"Ramsauer","sequence":"first","affiliation":[{"name":"Vivantes Hospital Neuk\u00f6lln, Babett Ramsauer, Perinatal Medicine, Rudowerstr. 48, D-12351 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex C.","family":"Vidaeff","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"H\u00f6sli","sequence":"additional","affiliation":[{"name":"University Hospital Basel, University of Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joong Shin","family":"Park","sequence":"additional","affiliation":[{"name":"College of Medicine, Seoul National University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Strauss","sequence":"additional","affiliation":[{"name":"University Hospital of Schleswig-Holstein, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zulfiya","family":"Khodjaeva","sequence":"additional","affiliation":[{"name":"Federal Research Center for Obstetrics and Gynecology and Perinatology, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel Aguar\u00f3n","family":"de la Cruz","sequence":"additional","affiliation":[{"name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Complutense University of Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Txant\u00f3n","family":"Mart\u00ednez-Astorquiza","sequence":"additional","affiliation":[{"name":"Cruces University Hospital, University of the Basque Country, Bilbao, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Horovitz","sequence":"additional","affiliation":[{"name":"University of Bordeaux, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Coatleven","sequence":"additional","affiliation":[{"name":"University of Bordeaux, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanns","family":"Helmer","sequence":"additional","affiliation":[{"name":"Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2012,12,25]]},"container-title":["jpme"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2012-0247\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2012-0247\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T03:23:06Z","timestamp":1678764186000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2012-0247\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,25]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,12,25]]},"published-print":{"date-parts":[[2013,5,1]]}},"alternative-id":["10.1515\/jpm-2012-0247"],"URL":"https:\/\/doi.org\/10.1515\/jpm-2012-0247","relation":{},"ISSN":["1619-3997","0300-5577"],"issn-type":[{"value":"1619-3997","type":"electronic"},{"value":"0300-5577","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12,25]]}}}