{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:54:41Z","timestamp":1792695281521,"version":"4.5.0"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Perinatal Medicine"],"published-print":{"date-parts":[[2013,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>\n                  <jats:bold>Aim:<\/jats:bold> The present study attempts to understand the role of methylenetetrahydrofolate reductase C677T (<jats:italic>MTHFR C677T)<\/jats:italic> in recurrent pregnancy losses in North Indian women because of hyperhomocysteinemia in light of serum folate and vitamin B<jats:sub>12<\/jats:sub>.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methods:<\/jats:bold> One hundred and seven women with three or more consecutive unexplained recurrent pregnancy losses and 343 women with two or more successful and uncomplicated pregnancies were recruited. Plasma homocysteine, serum folate and vitamin B<jats:sub>12<\/jats:sub> were analyzed using chemiluminescence. <jats:italic>MTHFR C677T<\/jats:italic> detection was completed in all subjects.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold>\n                  <jats:italic>MTHFR<\/jats:italic> genotypic distribution among cases and controls showed no significant difference (P=0.409). However, <jats:italic>MTHFR C677T<\/jats:italic> polymorphism was found to be significantly associated with increased homocysteine in the case group (P=0.031). Hyperhomocysteinemia and vitamin B<jats:sub>12<\/jats:sub> deficiency were found to be significant risk factors for recurrent pregnancy loss (RPL) (OR=7.02 and 16.39, respectively). Folate deficiency was more common in controls (63.47%) as compared to the case group (2.56%).<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion:<\/jats:bold> Low vitamin B<jats:sub>12<\/jats:sub> increases homocysteine, specifically among T allele carrying case mothers, suggesting T allele is detrimental with B<jats:sub>12<\/jats:sub> deficiency. The study emphasizes the importance of vitamin B<jats:sub>12<\/jats:sub> in the prevention of RPL in North Indian women.<\/jats:p>","DOI":"10.1515\/jpm-2012-0252","type":"journal-article","created":{"date-parts":[[2013,6,5]],"date-time":"2013-06-05T21:48:37Z","timestamp":1370468917000},"page":"549-554","source":"Crossref","is-referenced-by-count":43,"title":["MTHFR C677T polymorphism, folate, vitamin B<sub>12<\/sub> and homocysteine in recurrent pregnancy losses: a case control study among north Indian women"],"prefix":"10.1515","volume":"41","author":[{"given":"Manju","family":"Puri","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Lady Hardinge Medical College, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lovejeet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Anthropology, University of Delhi, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gagandeep Kaur","family":"Walia","sequence":"additional","affiliation":[{"name":"South Asia Network for Chronic Diseases (SANCD), Safdarjang Development Area, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupak","family":"Mukhopadhhyay","sequence":"additional","affiliation":[{"name":"Inclen Trust International, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohinder Pal","family":"Sachdeva","sequence":"additional","affiliation":[{"name":"Department of Anthropology, University of Delhi, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubha Sagar","family":"Trivedi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Lady Hardinge Medical College, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep Kumar","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Anthropology, University of Delhi, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kallur Nava","family":"Saraswathy","sequence":"additional","affiliation":[{"name":"Department of Anthropology, University of Delhi, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2013,4,16]]},"container-title":["jpme"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2012-0252\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2012-0252\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T03:24:19Z","timestamp":1678764259000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2012-0252\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,16]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2013,5,16]]},"published-print":{"date-parts":[[2013,9,1]]}},"alternative-id":["10.1515\/jpm-2012-0252"],"URL":"https:\/\/doi.org\/10.1515\/jpm-2012-0252","relation":{},"ISSN":["1619-3997","0300-5577"],"issn-type":[{"value":"1619-3997","type":"electronic"},{"value":"0300-5577","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4,16]]}}}