{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T03:18:52Z","timestamp":1782184732954,"version":"3.54.5"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Perinatal Medicine"],"published-print":{"date-parts":[[2013,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>\n                  <jats:bold>Objective:<\/jats:bold> This study aims to treat patients with preterm premature rupture of the membranes (PPROM) and anhydramnion using continuous amnioinfusion through a subcutaneously implanted port system.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methods:<\/jats:bold> An amniotic fluid replacement port system was implanted in seven patients with PPROM and anhydramnion starting at the 20<jats:sup>th<\/jats:sup> week of gestation (range, 14\u201326 weeks) for long-term amnioinfusion. Saline solutions (2 L\/day; Jonosteril<jats:sup>\u00ae<\/jats:sup>, Sterofundin<jats:sup>\u00ae<\/jats:sup>, isotonic NaCl 0.9% solution, lactated Ringer\u2019s solution) and a hypotonic aqueous composition with reduced chloride content similar to the electrolyte concentration of human amniotic fluid were used for the continuous amnioinfusion.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> The mean duration of the PPROM delivery interval continued for 49 days (range, 9\u201369 days), with 3 weeks of amnioinfusion <jats:italic>via<\/jats:italic> the port system (range, 4\u201349). The newborns showed no signs of lung hypoplasia.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion:<\/jats:bold> Long-term lavage of the amniotic cavity <jats:italic>via<\/jats:italic> a subcutaneously implanted port system in patients with PPROM and anhydramnion may help prolong the pregnancy and avoid fetal lung hypoplasia. A hypotonic aqueous composition with reduced chloride content similar to human amniotic fluid can be safely used for amnioinfusion. Prospective randomized studies are ongoing.<\/jats:p>","DOI":"10.1515\/jpm-2012-0296","type":"journal-article","created":{"date-parts":[[2013,6,10]],"date-time":"2013-06-10T14:37:37Z","timestamp":1370875057000},"page":"657-663","source":"Crossref","is-referenced-by-count":16,"title":["Treatment of PPROM with anhydramnion in humans: first experience with different amniotic fluid substitutes for continuous amnioinfusion through a subcutaneously implanted port system"],"prefix":"10.1515","volume":"41","author":[{"given":"Michael","family":"Tchirikov","sequence":"first","affiliation":[{"name":"University Clinic of Obstetrics and Fetal Medicine, University Medical Center Halle (Saale), Martin Luther University of Halle-Wittenberg, Halle, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gauri","family":"Bapayeva","sequence":"additional","affiliation":[{"name":"Center for Life Sciences, Nazarbayev University, Astana, Republic of Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaxybay Sh.","family":"Zhumadilov","sequence":"additional","affiliation":[{"name":"Center for Life Sciences, Nazarbayev University, Astana, Republic of Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmina","family":"Dridi","sequence":"additional","affiliation":[{"name":"University Clinic of Obstetrics and Fetal Medicine, University Medical Center Halle (Saale), Martin Luther University of Halle-Wittenberg, Halle, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Harnisch","sequence":"additional","affiliation":[{"name":"Pharmaceutical Department, University Medical Center Halle (Saale), Martin Luther University of Halle-Wittenberg, Halle, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika","family":"Herrmann","sequence":"additional","affiliation":[{"name":"University Clinic of Obstetrics and Fetal Medicine, University Medical Center Halle (Saale), Martin Luther University of Halle-Wittenberg, Halle, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2013,6,11]]},"container-title":["jpme"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2012-0296\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2012-0296\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T03:24:36Z","timestamp":1678764276000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2012-0296\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,11]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2013,7,4]]},"published-print":{"date-parts":[[2013,11,1]]}},"alternative-id":["10.1515\/jpm-2012-0296"],"URL":"https:\/\/doi.org\/10.1515\/jpm-2012-0296","relation":{},"ISSN":["1619-3997","0300-5577"],"issn-type":[{"value":"1619-3997","type":"electronic"},{"value":"0300-5577","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6,11]]}}}