{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T13:14:57Z","timestamp":1775481297013,"version":"3.50.1"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Perinatal Medicine"],"published-print":{"date-parts":[[2014,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>\n                  <jats:bold>Aims:<\/jats:bold> The sFlt-1\/PlGF ratio has been evaluated as a diagnostic marker for preeclampsia (PE). The aim of this study was to explore the use of the sFlt-1\/PlGF ratio as an aid in prediction for PE.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methods:<\/jats:bold> 150 patients with a high risk for PE were enrolled in this prospective study. Groups were compared according to the pregnancy outcome: controls (n=114), intrauterine growth restriction (IUGR) (n=14) and PE (n=22) with subclassification early PE&lt;34 weeks (n=6). Measurements of sFlt-1 and PlGF were performed on the automated Elecsys system. Statistical comparison of the sFlt-1\/PlGF ratio in different outcome groups and a mixed model analysis using random intercept models were performed.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> The sFlt-1\/PlGF ratio was significantly higher in pregnancies complicated by PE up to 4 weeks before clinical diagnosis compared to controls (106.7\u00b147.7 vs. 21.0\u00b14.1; P=0.02). Levels of the sFlt-1\/PlGF ratio were higher throughout pregnancy in women with IUGR compared to PE\/control patients (intercept 1.57 vs. 1.30\/0.67; P&lt;0.05). The slope for the sFlt-1\/PlGF ratio was significantly higher in PE and IUGR pregnancies compared to controls, indicating that a steep increase of the sFlt-1\/PlGF ratio correlates with pathologic pregnancy outcomes.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion:<\/jats:bold> The sFlt-1\/PlGF ratio can identify pathologic pregnancy outcomes such as IUGR and PE before clinical diagnosis. Repeated measurements are necessary to assess the dynamics in serum values. The time-dependent slope of the sFlt-1\/PlGF ratio is predictive for future pregnancy outcome and risk of developing preeclampsia.<\/jats:p>","DOI":"10.1515\/jpm-2013-0074","type":"journal-article","created":{"date-parts":[[2013,8,8]],"date-time":"2013-08-08T20:12:30Z","timestamp":1375992750000},"page":"61-68","source":"Crossref","is-referenced-by-count":63,"title":["The importance of repeated measurements of the sFlt-1\/PlGF ratio for the prediction of preeclampsia and intrauterine growth restriction"],"prefix":"10.1515","volume":"42","author":[{"given":"Katharina","family":"Schoofs","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Charit\u00e9 University Medicine, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Grittner","sequence":"additional","affiliation":[{"name":"Department for Biostatistics and Clinical Epidemiology, Charit\u00e9 University Medicine, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresa","family":"Engels","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Charit\u00e9 University Medicine, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliane","family":"Pape","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, DRK Berlin Westend, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Denk","sequence":"additional","affiliation":[{"name":"Roche Professional Diagnostics, Penzberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Henrich","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Charit\u00e9 University Medicine, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Verlohren","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Charit\u00e9 University Medicine, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2013,8,9]]},"container-title":["jpme"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2013-0074\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2013-0074\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T03:26:32Z","timestamp":1678764392000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2013-0074\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,9]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,8,8]]},"published-print":{"date-parts":[[2014,1,1]]}},"alternative-id":["10.1515\/jpm-2013-0074"],"URL":"https:\/\/doi.org\/10.1515\/jpm-2013-0074","relation":{},"ISSN":["1619-3997","0300-5577"],"issn-type":[{"value":"1619-3997","type":"electronic"},{"value":"0300-5577","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8,9]]}}}