{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T07:31:31Z","timestamp":1767857491591,"version":"3.49.0"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Perinatal Medicine"],"published-print":{"date-parts":[[2013,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>\n                  <jats:bold>Objective<\/jats:bold>: The molecular basis of failure to progress in labor is poorly understood. This study was undertaken to characterize the myometrial transcriptome of patients with an arrest of dilatation (AODIL).<\/jats:p>\n               <jats:p>\n                  <jats:bold>Study design<\/jats:bold>: Human myometrium was prospectively collected from women in the following groups: (1) spontaneous term labor (TL; n=29) and (2) arrest of dilatation (AODIL; n=14). Gene expression was characterized using Illumina\u00ae HumanHT-12 microarrays. A moderated Student\u2019s <jats:italic>t<\/jats:italic>-test and false discovery rate adjustment were used for analysis. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) of selected genes was performed in an independent sample set. Pathway analysis was performed on the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway database using Pathway Analysis with Down-weighting of Overlapping Genes (PADOG). The MetaCore knowledge base was also searched for pathway analysis.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results<\/jats:bold>: (1) Forty-two differentially expressed genes were identified in women with an AODIL; (2) gene ontology analysis indicated enrichment of biological processes, which included regulation of angiogenesis, response to hypoxia, inflammatory response, and chemokine-mediated signaling pathway. Enriched molecular functions included transcription repressor activity, heat shock protein (Hsp) 90 binding, and nitric oxide synthase (NOS) activity; (3) MetaCore analysis identified immune response chemokine (C-C motif) ligand 2 (CCL2) signaling, muscle contraction regulation of endothelial nitric oxide synthase (eNOS) activity in endothelial cells, and triiodothyronine and thyroxine signaling as significantly overrepresented (false discovery rate &lt;0.05); (4) qRT-PCR confirmed the overexpression of Nitric oxide synthase 3 (<jats:italic>NOS3<\/jats:italic>); hypoxic ischemic factor 1A (<jats:italic>HIF1A<\/jats:italic>); Chemokine (C-C motif) ligand 2 (<jats:italic>CCL2<\/jats:italic>); angiopoietin-like 4 (<jats:italic>ANGPTL4<\/jats:italic>); ADAM metallopeptidase with thrombospondin type 1, motif 9 (<jats:italic>ADAMTS9<\/jats:italic>); G protein-coupled receptor 4 (<jats:italic>GPR4<\/jats:italic>); metallothionein 1A (<jats:italic>MT1A<\/jats:italic>); <jats:italic>MT2A<\/jats:italic>; and selectin E (<jats:italic>SELE<\/jats:italic>) in an AODIL.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion<\/jats:bold>: The myometrium of women with AODIL has a stereotypic transcriptome profile. This disorder has been associated with a pattern of gene expression involved in muscle contraction, an inflammatory response, and hypoxia. This is the first comprehensive and unbiased examination of the molecular basis of an AODIL.<\/jats:p>","DOI":"10.1515\/jpm-2013-0086","type":"journal-article","created":{"date-parts":[[2013,7,27]],"date-time":"2013-07-27T04:27:29Z","timestamp":1374899249000},"page":"665-681","source":"Crossref","is-referenced-by-count":46,"title":["Characterization of the myometrial transcriptome in women with an arrest of dilatation during labor"],"prefix":"10.1515","volume":"41","author":[{"given":"Piya","family":"Chaemsaithong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichchha","family":"Madan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Romero","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, NICHD, NIH, DHHS, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nandor Gabor","family":"Than","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adi L.","family":"Tarca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sorin","family":"Draghici","sequence":"additional","affiliation":[{"name":"Department of Computer Science, Wayne State University, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaurav","family":"Bhatti","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, NICHD, NIH, DHHS, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lami","family":"Yeo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moshe","family":"Mazor","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Soroka University Medical Center, School of Medicine, Ben-Gurion University of the Negev, Beer-Sheva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong Jai","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia S.","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tinnakorn","family":"Chaiworapongsa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2013,7,27]]},"container-title":["jpme"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2013-0086\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2013-0086\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T03:24:45Z","timestamp":1678764285000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2013-0086\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,27]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2013,7,27]]},"published-print":{"date-parts":[[2013,11,1]]}},"alternative-id":["10.1515\/jpm-2013-0086"],"URL":"https:\/\/doi.org\/10.1515\/jpm-2013-0086","relation":{},"ISSN":["1619-3997","0300-5577"],"issn-type":[{"value":"1619-3997","type":"electronic"},{"value":"0300-5577","type":"print"}],"subject":[],"published":{"date-parts":[[2013,7,27]]}}}