{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:01:12Z","timestamp":1773421272985,"version":"3.50.1"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>\n                  <jats:bold>Aims:<\/jats:bold> To deduce the origin of preeclampsia characterized by hypertension and proteinuraia on the basis of results from animal studies and its therapeutic strategies.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methods:<\/jats:bold> Sympathetic and parasympathetic zones of female non-pregnant rabbit brain were stimulated electrically with Kurotu\u2019s electrodes. Systolic blood pressure, urine volume, and proteinuria were evaluated before and after the stimulation of autonomic zones.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> Excitation, hypertension, urine reduction, cloudy urine, and proteinuria were observed following stimulation of the sympathetic zone. A stable state, low blood pressure, increased urine volume, and no proteinuria were observed following stimulation of the parasympathetic zone.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion:<\/jats:bold> Hypertension and proteinuria in preeclampsia are caused by continuous stimulation of the sympathetic nervous center in the hypothalamus through the innervation between the enlarged uterus and hypothalamus in the latter stages of pregnancy or in a complete hydatidiform mole. Future studies are needed to address the potential of pharmacological suppression of an overactive sympathetic nerve system.<\/jats:p>","DOI":"10.1515\/jpm-2013-0096","type":"journal-article","created":{"date-parts":[[2013,7,11]],"date-time":"2013-07-11T20:04:49Z","timestamp":1373573089000},"page":"233-237","source":"Crossref","is-referenced-by-count":7,"title":["Preeclampsia is caused by continuous sympathetic center excitation due to an enlarged pregnant uterus"],"prefix":"10.1515","volume":"42","author":[{"given":"Kazuo","family":"Maeda","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology (Emeritus), Tottori University Medical School, Nadamachi 3-125, Yonago, Tottoriken 683-0835, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2013,7,12]]},"container-title":["Journal of Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2013-0096\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2013-0096\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T03:25:37Z","timestamp":1678764337000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2013-0096\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,12]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,11,21]]},"published-print":{"date-parts":[[2014,3,1]]}},"alternative-id":["10.1515\/jpm-2013-0096"],"URL":"https:\/\/doi.org\/10.1515\/jpm-2013-0096","relation":{},"ISSN":["1619-3997","0300-5577"],"issn-type":[{"value":"1619-3997","type":"electronic"},{"value":"0300-5577","type":"print"}],"subject":[],"published":{"date-parts":[[2013,7,12]]}}}