{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T08:59:30Z","timestamp":1791622770944,"version":"4.3.4"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Perinatal Medicine"],"published-print":{"date-parts":[[2014,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>\n                  <jats:bold>Aim:<\/jats:bold> To investigate the influence of antenatal magnesium sulfate (MgSO<jats:sub>4<\/jats:sub>) application on cord blood brain-derived neurotrophic factor (BDNF) levels \u2013 the first-line neuroprotection for preventing cerebral palsy in prematurely born infants.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Subjects and methods:<\/jats:bold> A randomized controlled trial was conducted by observing 72 pregnant women who were divided into three groups: group I (preterm pregnancy with MgSO<jats:sub>4<\/jats:sub>), group II (preterm pregnancy without MgSO<jats:sub>4<\/jats:sub>), and group III (full-term pregnancy as control group). Groups I and II were selected by block permutation randomization on subjects. Inclusion criteria consisted of preterm pregnancy at 34 weeks of gestation or less who were in labor or having planned terminations and receiving antenatal corticosteroids. Exclusion criteria consisted of previous complications caused by MgSO<jats:sub>4<\/jats:sub>, previous history of antenatal MgSO<jats:sub>4<\/jats:sub> application in the current pregnancy infant was born before 4 h administration of MgSO<jats:sub>4<\/jats:sub> or unborn more than 72 h after maximum course of antenatal MgSO<jats:sub>4<\/jats:sub> of 24 h, prolonged antenatal MgSO<jats:sub>4<\/jats:sub> treatment (&gt;24 h), refusal to participate, and emergent adverse events during the study. Group I was given intravenous MgSO<jats:sub>4<\/jats:sub>; initial dose was 4 g, which was maintained at 1 g\/h up to maximum of 24 h. Meanwhile, groups II and III were not given any special treatment. BDNF was examined by ELISA by taking 5 mL cord blood sample shortly after birth. The result was statistically measured by ANOVA.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> The cord blood BDNF levels in premature infants with antenatal MgSO<jats:sub>4<\/jats:sub> was significantly higher than in premature infants without antenatal MgSO<jats:sub>4<\/jats:sub> (11,568 vs. 5027 pg\/mL, P=0.000). Moreover, the result was statistically comparable to full-term infants (11,568 vs. 13,300 pg\/mL, P=0.085).<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion:<\/jats:bold> The application of antenatal MgSO<jats:sub>4<\/jats:sub> in preterm delivery increased cord blood BDNF levels, which could have a potential role on fetal neuroprotection. Further investigation is needed.<\/jats:p>","DOI":"10.1515\/jpm-2013-0137","type":"journal-article","created":{"date-parts":[[2013,9,23]],"date-time":"2013-09-23T20:27:57Z","timestamp":1379968077000},"page":"129-134","source":"Crossref","is-referenced-by-count":26,"title":["Influence of antenatal magnesium sulfate application on cord blood levels of brain-derived neurotrophic factor in premature infants"],"prefix":"10.1515","volume":"42","author":[{"given":"Muhammad Adrianes","family":"Bachnas","sequence":"first","affiliation":[{"name":"Fetomaternal Division, Department of Obstetrics and Gynecology, Medical Faculty of Sebelas Maret University, Moewardi Hospital, Solo, Surakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanes Cornelius","family":"Mose","sequence":"additional","affiliation":[{"name":"Fetomaternal Division, Department of Obstetrics and Gynecology, Medical Faculty of Padjadjaran University, Hasan Sadikin Hospital, Bandung, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jusuf Sulaeman","family":"Effendi","sequence":"additional","affiliation":[{"name":"Fetomaternal Division, Department of Obstetrics and Gynecology, Medical Faculty of Padjadjaran University, Hasan Sadikin Hospital, Bandung, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiku","family":"Andonotopo","sequence":"additional","affiliation":[{"name":"Fetomaternal Division, Department of Obstetrics and Gynecology, Medical Faculty of Indonesia University, Tangerang General District Hospital, Banten, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2013,9,24]]},"container-title":["jpme"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2013-0137\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2013-0137\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T03:26:34Z","timestamp":1678764394000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2013-0137\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,24]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,8,8]]},"published-print":{"date-parts":[[2014,1,1]]}},"alternative-id":["10.1515\/jpm-2013-0137"],"URL":"https:\/\/doi.org\/10.1515\/jpm-2013-0137","relation":{},"ISSN":["1619-3997","0300-5577"],"issn-type":[{"value":"1619-3997","type":"electronic"},{"value":"0300-5577","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9,24]]}}}