{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T01:37:23Z","timestamp":1768354643655,"version":"3.49.0"},"reference-count":26,"publisher":"Walter de Gruyter GmbH","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>\n                  <jats:bold>Objective:<\/jats:bold> To investigate the relation between first-trimester fetal growth discrepancy, as assessed by crown-rump length (CRL) at 11+0 to 13+6 weeks of gestation, and subsequent development of preeclampsia (PE) in dichorionic diamniotic (DCDA) twin pregnancies. The association between inter-twin CRL and birth weight (BW) discrepancy was also investigated.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methods:<\/jats:bold> This was a retrospective, case-control study of DCDA twin pregnancies. Inter-twin CRL discrepancy was calculated as 100\u00d7(larger CRL\u2013smaller CRL)\/larger CRL. BW discordance was calculated as 100\u00d7(larger BW\u2013smaller BW)\/larger BW.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> The study included 299 DCDA pregnancies that remained normotensive and 35 that subsequently developed PE. There was no significant difference in the inter-twin CRL discrepancy between pregnancies complicated by PE and those that were not [3.2%, interquartile range (IQR): 0.5\u20134.5% vs. 3.3%, IQR: 1.4\u20135.5%; P=0.17]. There was a positive correlation between inter-twin CRL and BW discrepancy but only in pregnancies that remained normotensive (P&lt;0.001). In women that subsequently developed PE, there was no association between inter-twin CRL and BW discordance (P=0.54).<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusions:<\/jats:bold> In unselected DCDA twins, first-trimester CRL discrepancy is not different between pregnancies that subsequently develop PE and those that remain normotensive. Furthermore, in pregnancies that are complicated by PE, the association between inter-twin CRL and BW discrepancy appears to be lost.<\/jats:p>","DOI":"10.1515\/jpm-2013-0260","type":"journal-article","created":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T03:29:05Z","timestamp":1395718145000},"page":"755-759","source":"Crossref","is-referenced-by-count":6,"title":["First-trimester fetal growth discordance and development of preeclampsia in dichorionic twin pregnancies"],"prefix":"10.1515","volume":"43","author":[{"given":"Tanya","family":"Maric","sequence":"first","affiliation":[{"name":"Fetal Medicine Unit, Academic Department of Obstetrics and Gynaecology, Chelsea and Westminster Hospital, Imperial College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasha","family":"Singh","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Academic Department of Obstetrics and Gynaecology, Chelsea and Westminster Hospital, Imperial College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith","family":"Duncan","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Academic Department of Obstetrics and Gynaecology, Chelsea and Westminster Hospital, Imperial College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy J.","family":"Thorpe-Beeston","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Academic Department of Obstetrics and Gynaecology, Chelsea and Westminster Hospital, Imperial College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makrina D.","family":"Savvidou","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Academic Department of Obstetrics and Gynaecology, Chelsea and Westminster Hospital, Imperial College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2014,3,25]]},"reference":[{"key":"2023031403224579211_j_jpm-2013-0260_ref_001_w2aab2b8b2b1b7b1ab2ab1Aa","doi-asserted-by":"crossref","unstructured":"Achiron R, Blickstein I. Persistent discordant twin growth following IVF-ET. Acta Genet Med Gemellol. 1993;42:41\u20134.10.1017\/S051528360004227X","DOI":"10.1017\/S051528360004227X"},{"key":"2023031403224579211_j_jpm-2013-0260_ref_002_w2aab2b8b2b1b7b1ab2ab2Aa","doi-asserted-by":"crossref","unstructured":"Bhide A, Sankaran S, Sairam S, Papageorghiou AT, Thilaganathan B. Relationship of intertwin crown-rump length discrepancy to chorionicity, fetal demise and birth-weight discordance. Ultrasound Obstet Gynecol. 2009;34:131\u20135.10.1002\/uog.6396","DOI":"10.1002\/uog.6396"},{"key":"2023031403224579211_j_jpm-2013-0260_ref_003_w2aab2b8b2b1b7b1ab2ab3Aa","unstructured":"Blickstein I, Goldman RD. Inter-twin birth weight discordance as a potential adaptive measure to promote gestational age. J Reprod Med. 2003;48:449\u201354."},{"key":"2023031403224579211_j_jpm-2013-0260_ref_004_w2aab2b8b2b1b7b1ab2ab4Aa","doi-asserted-by":"crossref","unstructured":"Blickstein I, Lancet M. The growth discordant twin. Obstet Gynecol Surv. 1988;43:509\u201315.10.1097\/00006254-198809000-00002","DOI":"10.1097\/00006254-198809000-00002"},{"key":"2023031403224579211_j_jpm-2013-0260_ref_005_w2aab2b8b2b1b7b1ab2ab5Aa","doi-asserted-by":"crossref","unstructured":"Blickstein I, Goldman RD, Mazkereth R. Adaptive growth restriction as a pattern of birth weight discordance in twin gestations. Obstet Gynecol. 2000;96:986\u201390.","DOI":"10.1097\/00006250-200012000-00022"},{"key":"2023031403224579211_j_jpm-2013-0260_ref_006_w2aab2b8b2b1b7b1ab2ab6Aa","doi-asserted-by":"crossref","unstructured":"Bulfin MJ, Lawler PE. Problems associated with toxemia in twin pregnancies. Am J Obstet Gynecol. 1957;73:37\u201342.10.1016\/S0002-9378(16)37264-7","DOI":"10.1016\/S0002-9378(16)37264-7"},{"key":"2023031403224579211_j_jpm-2013-0260_ref_007_w2aab2b8b2b1b7b1ab2ab7Aa","doi-asserted-by":"crossref","unstructured":"Cheung VYT, Bocking AD, Dasilva OP. Preterm discordant twins: what birth weight difference is significant? Obstet Gynecol. 1995;172:955\u20139.10.1016\/0002-9378(95)90027-6","DOI":"10.1016\/0002-9378(95)90027-6"},{"key":"2023031403224579211_j_jpm-2013-0260_ref_008_w2aab2b8b2b1b7b1ab2ab8Aa","doi-asserted-by":"crossref","unstructured":"Coonrod DV, Hickok DE, Zhu K, Easterling TR, Daling JR. Risk factors for preeclampsia in twin pregnancies: a population-based cohort study. Obstet Gynecol. 1995;85:645\u201350.10.1016\/0029-7844(95)00049-W","DOI":"10.1016\/0029-7844(95)00049-W"},{"key":"2023031403224579211_j_jpm-2013-0260_ref_009_w2aab2b8b2b1b7b1ab2ab9Aa","doi-asserted-by":"crossref","unstructured":"Cooperstock MS, Tummaro R, Bakewell J, Schramm W. Twin birth weight discordance and risk of preterm birth. Am J Obstet Gynecol. 2000;183:63\u20137.10.1016\/S0002-9378(00)55604-X","DOI":"10.1016\/S0002-9378(00)55604-X"},{"key":"2023031403224579211_j_jpm-2013-0260_ref_010_w2aab2b8b2b1b7b1ab2ac10Aa","doi-asserted-by":"crossref","unstructured":"D\u2019Antonio F, Khalil A, Dias T, Thilaganathan B; Southwest Thames Obstetric Research Collaborative (STORK). Weight discordance and perinatal mortality in twins: analysis of the Southwest Thames Obstetric Research Collaborative (STORK) multiple pregnancy cohort. Ultrasound Obstet Gynecol. 2013;41:643\u20138.10.1002\/uog.12412","DOI":"10.1002\/uog.12412"},{"key":"2023031403224579211_j_jpm-2013-0260_ref_011_w2aab2b8b2b1b7b1ab2ac11Aa","doi-asserted-by":"crossref","unstructured":"Davey DA, MacGillivray I. The classification and definition of the hypertensive disorders of pregnancy. Am J Obstet Gynecol. 1988;158:892\u20138.10.1016\/0002-9378(88)90090-7","DOI":"10.1016\/0002-9378(88)90090-7"},{"key":"2023031403224579211_j_jpm-2013-0260_ref_012_w2aab2b8b2b1b7b1ab2ac12Aa","doi-asserted-by":"crossref","unstructured":"Demissie K, Ananth CV, Martin J, Hanley ML, MacDorman MF, Rhoads GG. Fetal and neonatal mortality among twin gestations in the United States: the role of intrapair birth weight discordance. Obstet Gynecol. 2002;100:474\u201380.10.1097\/00006250-200209000-00013","DOI":"10.1097\/00006250-200209000-00013"},{"key":"2023031403224579211_j_jpm-2013-0260_ref_013_w2aab2b8b2b1b7b1ab2ac13Aa","doi-asserted-by":"crossref","unstructured":"Dickey RP, Gasser RF. Ultrasound evidence for variability in the size and development of normal human embryos before the tenth post-insemination week after assisted reproductive technologies. Hum Reprod. 1993;8:331\u20137.10.1093\/oxfordjournals.humrep.a138046","DOI":"10.1093\/oxfordjournals.humrep.a138046"},{"key":"2023031403224579211_j_jpm-2013-0260_ref_014_w2aab2b8b2b1b7b1ab2ac14Aa","doi-asserted-by":"crossref","unstructured":"Fareeduddin R, Williams J 3rd, Solt I, Mirocha JM, Kim MJ, Rotmensch S. Discordance of first-trimester crown-rump length is a predictor of adverse outcomes in structurally normal euploid dichorionic twins. J Ultrasound Med. 2010;29:1439\u201343.10.7863\/jum.2010.29.10.1439","DOI":"10.7863\/jum.2010.29.10.1439"},{"key":"2023031403224579211_j_jpm-2013-0260_ref_015_w2aab2b8b2b1b7b1ab2ac15Aa","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-Quintero VH, Luke B, O\u2019Sullivan MJ, Misiunas R, Anderson E, Nugent C, et al. Antenatal factors associated with significant birth weight discordancy in twin gestations. Am J Obstet Gynecol. 2003;189:813\u20137.10.1067\/S0002-9378(03)00658-6","DOI":"10.1067\/S0002-9378(03)00658-6"},{"key":"2023031403224579211_j_jpm-2013-0260_ref_016_w2aab2b8b2b1b7b1ab2ac16Aa","doi-asserted-by":"crossref","unstructured":"Granger JP, Alexander BT, Llinas MT, Bennett WA, Khalil RA. Pathophysiology of preeclampsia: linking placental ischemia\/hypoxia with microvascular dysfunction. Microcirculation. 2002;9:147\u201360.10.1038\/sj.mn.7800137","DOI":"10.1038\/sj.mn.7800137"},{"key":"2023031403224579211_j_jpm-2013-0260_ref_017_w2aab2b8b2b1b7b1ab2ac17Aa","doi-asserted-by":"crossref","unstructured":"Harper LM, Roehl KA, Odibo AO, Cahill AG. First-trimester growth discordance and adverse pregnancy outcome in dichorionic twins. Ultrasound Obstet Gynecol. 2013;41:627\u201331.10.1002\/uog.11225","DOI":"10.1002\/uog.11225"},{"key":"2023031403224579211_j_jpm-2013-0260_ref_018_w2aab2b8b2b1b7b1ab2ac18Aa","doi-asserted-by":"crossref","unstructured":"Hollier LM, McIntire DD, Leveno KJ. Outcome of twin pregnancies according to intrapair birth weight differences. Obstet Gynecol. 1999;94:1006\u201310.","DOI":"10.1097\/00006250-199912000-00019"},{"key":"2023031403224579211_j_jpm-2013-0260_ref_019_w2aab2b8b2b1b7b1ab2ac19Aa","doi-asserted-by":"crossref","unstructured":"Isada NB, Sorokin Y, Drugan A, Johnson MP, Zador I, Evans MI. First trimester interfetal size variation in well-dated multifetal pregnancies. Fetal Diagn Ther. 1992;7:82\u20136.10.1159\/000263654","DOI":"10.1159\/000263654"},{"key":"2023031403224579211_j_jpm-2013-0260_ref_020_w2aab2b8b2b1b7b1ab2ac20Aa","doi-asserted-by":"crossref","unstructured":"Kagan KO, Gazzoni A, Sepulveda-Gonzalez G, Sotiriadis A, Nicolaides KH. Discordance in nuchal translucency thickness in the prediction of severe twin-to-twin transfusion syndrome. Ultrasound Obstet Gynecol. 2007;29:527\u201332.10.1002\/uog.4006","DOI":"10.1002\/uog.4006"},{"key":"2023031403224579211_j_jpm-2013-0260_ref_021_w2aab2b8b2b1b7b1ab2ac21Aa","doi-asserted-by":"crossref","unstructured":"Kalish RB, Chasen ST, Gupta M, Sharma G, Perni SC, Chervenak FA. First trimester prediction of growth discordance in twin gestations. Am J Obstet Gynecol. 2003;189:706\u20139.10.1067\/S0002-9378(03)00714-2","DOI":"10.1067\/S0002-9378(03)00714-2"},{"key":"2023031403224579211_j_jpm-2013-0260_ref_022_w2aab2b8b2b1b7b1ab2ac22Aa","doi-asserted-by":"crossref","unstructured":"Kalish RB, Gupta M, Perni SC, Berman S, Chasen ST. Clinical significance of first trimester crown-rump length disparity in dichorionic twin gestations. Am J Obstet Gynecol. 2004;191:1437\u201340.10.1016\/j.ajog.2004.06.10115507979","DOI":"10.1016\/j.ajog.2004.06.101"},{"key":"2023031403224579211_j_jpm-2013-0260_ref_023_w2aab2b8b2b1b7b1ab2ac23Aa","doi-asserted-by":"crossref","unstructured":"McFarlane A, Scott JS. Pre-eclampsia\/eclampsia in twin pregnancies. J Med Genet. 1976;13:208\u201311.10.1136\/jmg.13.3.2081013394933121","DOI":"10.1136\/jmg.13.3.208"},{"key":"2023031403224579211_j_jpm-2013-0260_ref_024_w2aab2b8b2b1b7b1ab2ac24Aa","unstructured":"Sannoh S, Demissie K, Balasubramanian B, Rhoads GG. Risk factors for intrapair birth weight discordance in twins. Arch Gynecol Obstet. 2003;269:33\u20136.10.1080\/jmf.13.4.230.23612854922"},{"key":"2023031403224579211_j_jpm-2013-0260_ref_025_w2aab2b8b2b1b7b1ab2ac25Aa","doi-asserted-by":"crossref","unstructured":"Sepulveda W, Sebire NJ, Hughes K, Odibo A, Nicolaides KH. The lambda sign at 10-14 weeks of gestation as a predictor of chorionicity in twin pregnancies. Ultrasound Obstet Gynecol. 1996;7:421\u20133.10.1046\/j.1469-0705.1996.07060421.x8807758","DOI":"10.1046\/j.1469-0705.1996.07060421.x"},{"key":"2023031403224579211_j_jpm-2013-0260_ref_026_w2aab2b8b2b1b7b1ab2ac26Aa","doi-asserted-by":"crossref","unstructured":"Smith GC, Smith MF, McNay MB, Fleming JE. First-trimester growth and the risk of low birth weight. N Engl J Med. 1998;339:1817\u201322.10.1056\/NEJM1998121733925049854117","DOI":"10.1056\/NEJM199812173392504"}],"container-title":["Journal of Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2013-0260\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2013-0260\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T03:23:49Z","timestamp":1678764229000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2013-0260\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,25]]},"references-count":26,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,3,25]]},"published-print":{"date-parts":[[2015,11,1]]}},"alternative-id":["10.1515\/jpm-2013-0260"],"URL":"https:\/\/doi.org\/10.1515\/jpm-2013-0260","relation":{},"ISSN":["1619-3997","0300-5577"],"issn-type":[{"value":"1619-3997","type":"electronic"},{"value":"0300-5577","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3,25]]}}}