{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:10:51Z","timestamp":1761919851014},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>\n                  <jats:bold>Aims:<\/jats:bold> To analyze the clinical differences between early- and late-onset cases of severe preeclampsia and to evaluate parameters that could help to predict perinatal outcome.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methods:<\/jats:bold> Over a period of 6 years, all cases of severe preeclampsia (n=68) at our institution were included in a retrospective cohort analysis. Differences between early (&lt;34 weeks, n=44) and late (\u226534 weeks, n=24) onset of the disease were evaluated. Risk factors for low 5-min Apgar score (\u22647), small-for-gestational-age (SGA) infants and neonatal acidosis (umbilical arterial pH &lt;7.20) were identified and considered in a multiple logistic regression model.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> Early- and late-onset severe preeclampsia differed from each other remarkably. Perinatal outcome was unfavorable in early-onset disease and seemed to be mainly a result of premature delivery and development of fetal growth restriction. Abnormal uterine Doppler velocimetry increased the risk of low 5-min Apgar values [odds ratio (OR) 8.0, P=0.012] and preterm birth &lt;34+0 weeks (OR 17.9, P&lt;0.001). An increased resistance of the umbilical artery was associated with a higher risk for SGA birth weight (OR 4.9, P=0.010).<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion:<\/jats:bold> Preeclampsia is a heterogeneous syndrome even if only severe cases were analyzed. Abnormal Doppler flow characteristics facilitated the identification of patients who were at increased risk for worse perinatal outcome.<\/jats:p>","DOI":"10.1515\/jpm-2013-0285","type":"journal-article","created":{"date-parts":[[2014,5,21]],"date-time":"2014-05-21T12:50:56Z","timestamp":1400676656000},"page":"617-627","source":"Crossref","is-referenced-by-count":22,"title":["Clinical differences between early- and late-onset severe preeclampsia and analysis of predictors for perinatal outcome"],"prefix":"10.1515","volume":"42","author":[{"given":"Johannes","family":"Stubert","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Rostock, Suedring 81, 18059 Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie","family":"Ullmann","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Rostock, Suedring 81, 18059 Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max","family":"Dieterich","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Rostock, Suedring 81, 18059 Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doreen","family":"Diedrich","sequence":"additional","affiliation":[{"name":"Institute for Statistics and Informatics in Medicine and Ageing Research, University of Rostock, 18057 Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toralf","family":"Reimer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Rostock, Suedring 81, 18059 Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2014,4,26]]},"container-title":["Journal of Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2013-0285\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2013-0285\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T14:05:15Z","timestamp":1680357915000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2013-0285\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,26]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,2,21]]},"published-print":{"date-parts":[[2014,9,1]]}},"alternative-id":["10.1515\/jpm-2013-0285"],"URL":"https:\/\/doi.org\/10.1515\/jpm-2013-0285","relation":{},"ISSN":["1619-3997","0300-5577"],"issn-type":[{"value":"1619-3997","type":"electronic"},{"value":"0300-5577","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4,26]]}}}