{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T11:56:17Z","timestamp":1783338977364,"version":"3.54.6"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>\n                  <jats:bold>Background:<\/jats:bold> Cytomegalovirus (CMV) causes congenital infection with high mortality and morbidity rates in affected neonates.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Objectives:<\/jats:bold> To evaluate the maternal IgG avidity value for the prediction of congenital CMV infection.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Study design:<\/jats:bold> The serum IgG avidity in all mothers was measured, and the urine of their neonates was assessed for CMV DNA in a prospective cohort study.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> Of 759 women with a positive test for CMV IgG, 14 had congenital CMV infection. CMV IgG avidity indices in the congenital infection group (median 35.1%) were significantly lower than those in the non-congenital infection group (70.4%). A cutoff value of &lt;40% IgG avidity index with 96.1% specificity and 64.3% sensitivity for congenital infection was determined by receiver operating characteristic curve analyses. The highest sensitivity (88.9%), 96.2% specificity, 27.6% positive predictive value, 99.8% negative predictive value, and 96.1% accuracy were found when IgG avidity was measured in &lt;28 weeks of gestation.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion:<\/jats:bold> The IgG avidity measurement with a cutoff value of &lt;40% IgG avidity index might be helpful in predicting congenital CMV infection, especially in &lt;28 weeks of gestation.<\/jats:p>","DOI":"10.1515\/jpm-2013-0333","type":"journal-article","created":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T03:29:05Z","timestamp":1395718145000},"page":"755-759","source":"Crossref","is-referenced-by-count":18,"title":["The IgG avidity value for the prediction of congenital cytomegalovirus infection in a prospective cohort study"],"prefix":"10.1515","volume":"42","author":[{"given":"Yasuhiko","family":"Ebina","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Minematsu","sequence":"additional","affiliation":[{"name":"Research Center for Disease Control, Aisenkai Nichinan Hospital, Miyazaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Sonoyama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Morioka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Inoue","sequence":"additional","affiliation":[{"name":"National Institute of Infectious Diseases, Department of Virology I, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Tairaku","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Nagamata","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Tanimura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Morizane","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Deguchi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideto","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2014,3,25]]},"container-title":["Journal of Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2013-0333\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2013-0333\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T03:23:11Z","timestamp":1678764191000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2013-0333\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,25]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,4,3]]},"published-print":{"date-parts":[[2014,11,1]]}},"alternative-id":["10.1515\/jpm-2013-0333"],"URL":"https:\/\/doi.org\/10.1515\/jpm-2013-0333","relation":{},"ISSN":["1619-3997","0300-5577"],"issn-type":[{"value":"1619-3997","type":"electronic"},{"value":"0300-5577","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3,25]]}}}