{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:01:09Z","timestamp":1787702469039,"version":"build-2784847793"},"reference-count":18,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tricuspid regurgitation (TR) is a common sonographic finding during the fetal life. It has been reported in 7% of normal fetuses. It may be associated with aneuploidy and with both cardiac and extracardiac defects.<\/jats:p><jats:p>In this study, we have looked at the characteristics of fetuses with and without TR at 11<\/jats:p><jats:p>The study group included women, who underwent an ultrasound examination at 11\u201313<\/jats:p><jats:p>Some 1075 patients met our inclusion criteria including 979 fetuses without TR and 96 with TR. There were 72 cases of aneuploidy diagnosed (6.7%). Isolated TR was found in 53 euploid fetuses (5.2%). All of the TR(+) aneuploid fetuses (n=40) had additional ultrasound markers present. Extracardiac anatomy showed a higher prevalence of abnormalities in the group of TR positives (12.5%) vs. TR negatives (1.6%). Abnormal cardiac findings were more frequent in the TR-positive group independently of chromosomal status and were found in 18.8% of fetuses with TR and in 1.9% with a normal tricuspid flow.<\/jats:p><jats:p>TR in combination with other markers is the strongest predictor for aneuploidy. TR, as an isolated parameter, is a poor screening tool both for all and for each individual chromosomal abnormality and congenital cardiac defects.<\/jats:p>","DOI":"10.1515\/jpm-2014-0058","type":"journal-article","created":{"date-parts":[[2014,5,21]],"date-time":"2014-05-21T12:54:41Z","timestamp":1400676881000},"source":"Crossref","is-referenced-by-count":19,"title":["First trimester tricuspid regurgitation and fetal abnormalities"],"prefix":"10.1515","volume":"43","author":[{"given":"Marcin","family":"Wiechec","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Nocun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Wiercinska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Beithon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Knafel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref41","first-page":"374","article-title":"The prevalence and clinical significance of tricuspid valve regurgitation in normally grown fetuses and those with intrauterine growth retardation Ultrasound","author":"Gembruch","year":"1997","journal-title":"Obstet Gynecol"},{"key":"ref161","first-page":"374","article-title":"The prevalence and clinical significance of tricuspid valve regurgitation in normally grown fetuses and those with intrauterine growth retardation Ultrasound","author":"Gembruch","year":"1997","journal-title":"Obstet Gynecol"},{"key":"ref201","first-page":"101","article-title":"Comparsion of hemodynamic data before and after corrective surgery for Down s syndrome and ventricular septal defects","author":"Kawai","year":"1995","journal-title":"Heart Vessels"},{"key":"ref91","article-title":"de Analysis of secondary ultrasound markers in the first trimester before chorionic villus sampling","volume":"30","author":"Molina Garcia","year":"2010"},{"key":"ref221","first-page":"1","article-title":"Chronic lung diseases of the children","author":"Rait","year":"2001"},{"key":"ref71","first-page":"13","article-title":"Improved diagnostic accuracy by using secondary ultrasound markers in the first - 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trimester screening for trisomies syndrome","volume":"21","author":"Karadzov","year":"2012"}],"container-title":["Journal of Perinatal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2014-0058\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T01:31:16Z","timestamp":1619055076000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2014-0058\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,1]]},"references-count":18,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.1515\/jpm-2014-0058","relation":{},"ISSN":["1619-3997","0300-5577"],"issn-type":[{"value":"1619-3997","type":"electronic"},{"value":"0300-5577","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1,1]]}}}