{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:33:58Z","timestamp":1757705638653},"reference-count":62,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to determine the relationship between sonographic cervical length, fetal fibronectin (fFN), phIGFBP-1 (actim partus test), cytokines (IL-6, IL-2R, and TNF-\u03b1), and spontaneous preterm birth (SPTB) up to 14 days from sampling.<\/jats:p><jats:p>Fifty-eight patients were recruited in a period of 6 months from September 2013 until March 2014 with symptoms or complaints suggestive of preterm labor. Consenting women were treated according to usual hospital protocol, with addition of vaginal swabs taken for fetal fibronectin, phIGFBP-1 (actim partus test) and cervical IL6, IL2R, and TNF-\u03b1. The outcome variable was occurrence of preterm delivery within 14 days from the day of hospital admission.<\/jats:p><jats:p>Thirty-six patients (62.07%) were delivered within 14 days from admission. Our results indicated that the cervical length significantly inversely correlates with the concentration of IL-6 in the CVF (Spearman\u2019s coefficient R=\u20130.382, P&lt;0.05). Cervical length also correlated with a positive phIGFBP-1 test, i.e., patients with a positive test had an average cervical length of 18.5\u00b14.63 mm, which is significantly lower than patients with a negative test \u201323.43\u00b17.39 mm (P=0.003).<\/jats:p><jats:p>The studied biochemical markers were only moderately successful in the prediction of preterm delivery.<\/jats:p>","DOI":"10.1515\/jpm-2014-0275","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T16:02:18Z","timestamp":1418400138000},"source":"Crossref","is-referenced-by-count":8,"title":["Correlation of cervical length, fetal fibronectin, phIGFBP-1, and cytokines in spontaneous preterm birth up to 14 days from sampling"],"prefix":"10.1515","volume":"43","author":[{"given":"Marija","family":"Had\u017ei-Lega","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Daneva","family":"Markova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milan","family":"Stefanovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mile","family":"Tanturovski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref121","first-page":"108","article-title":"DA Magnesium sulfate tocolysis time to quit","author":"Grimes","year":"2006","journal-title":"Obstet Gynecol"},{"key":"ref471","first-page":"1","article-title":"Prophylactic oral betamimetics for preventing preterm labour in singleton pregnancies CD","author":"Whitworth","year":"2008","journal-title":"Database Syst Rev"},{"key":"ref571","first-page":"421","article-title":"Selective use of sonographic cervical length measurement for predicting imminent preterm delivery in women with preterm labor and intact membranes Ultrasound","volume":"31","author":"Schmitz","year":"2008","journal-title":"Obstet Gynecol"},{"key":"ref481","first-page":"95","article-title":"The effect of transport on the rate of severe intraventricular hemorrhage in very low birth weight infants","author":"Towers","year":"2000","journal-title":"Obstet Gynecol"},{"key":"ref241","first-page":"421","article-title":"Selective use of sonographic cervical length measurement for predicting imminent preterm delivery in women with preterm labor and intact membranes Ultrasound","volume":"31","author":"Schmitz","year":"2008","journal-title":"Obstet Gynecol"},{"key":"ref151","first-page":"95","article-title":"The effect of transport on the rate of severe intraventricular hemorrhage in very low birth weight infants","author":"Towers","year":"2000","journal-title":"Obstet Gynecol"},{"key":"ref491","first-page":"178","article-title":"Changing patterns in regionalization of perinatal care and the impact on neonatal mortality","author":"Poskin","year":"1998","journal-title":"Yeast Am J Obstet Gynecol"},{"key":"ref261","first-page":"113","article-title":"To birth the value of sonographic measurement of cervical length","volume":"52","author":"Kagan KO","year":"2006","journal-title":"Obstet Gynecol"},{"key":"ref201","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1055\/s-2008-1061497","article-title":"AT MO Multidimensional system biology : genetic markers and proteomic biomarkers of adverse pregnancy outcome in preterm birth","volume":"25","author":"Buhimschi","year":"2008","journal-title":"Am J Perinatol"},{"key":"ref311","first-page":"1","article-title":"Evaluation of a bedside test for phosphorylated insulin - 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